Therapeutic Effect of Topical Gamma-Linolenic Acid on Refractory Uremic Pruritus

American Journal of Kidney Diseases

Volumn 48, Issue 1, 2006, Pages 69-76

  Chen, Yung Chih ^a,b,c   Chiu, Wan Ting ^a,b,c   Wu, Mai Szu ^a,b,c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CATHAY GENERAL HOSPITAL   (Taiwan)

Author keywords

Gamma linolenic acid; uremic pruritus

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTIC ACID; BILIRUBIN; CALCIUM; CREATININE; GAMMA LINOLENIC ACID; PARATHYROID HORMONE;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; ERYTHEMA; EVALUATION; FEMALE; HEMODIALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; PRURITUS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCREENING; SEX RATIO; SKIN ALLERGY; UREA NITROGEN BLOOD LEVEL; UREMIC PRURITUS; VISUAL ANALOG SCALE;

ADMINISTRATION, TOPICAL; ADULT; AGED; DOUBLE-BLIND METHOD; DRUG RESISTANCE; FEMALE; GAMMA-LINOLENIC ACID; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PRURITUS; RENAL DIALYSIS; TREATMENT OUTCOME; UREMIA;

EID: 33745210805     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2006.03.082     Document Type: Article

References (43)

1. Ponticelli C., and Bencini P.L. Uremic pruritus. A review. Nephron 60 (1992) 1-5
2. Morton C.A., Lafferty M., Hau C., Henderson I., Jones M., and Lowe J.G. Pruritus and skin hydration during dialysis. Nephrol Dial Transplant 11 (1996) 2031-2036
3. Carmichael A.J., McHugh M.M., Martin A.M., and Farrow M. Serological markers of renal itch in patients receiving long term haemodialysis. Br Med J 296 (1988) 1575
4. Katz A.I., Hampers C.L., and Merrill J.P. Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure. Analysis of 195 patients, with observations on the effects of chronic dialysis, kidney transplantation and subtotal parathyroidectomy. Medicine 48 (1969) 333-374
5. Dimkovic N., Djukanovic L., Radmilovic A., Bojic P., and Juloski T. Uremic pruritus and skin mast cells. Nephron 61 (1992) 5-9
6. Valsecchi R., and Cainelli T. Generalized pruritus. A manifestation of iron deficiency. Arch Dermatol 119 (1983) 630
7. Stockenhuber F., Sunder-Plassmann G., and Balcke P. Increased plasma histamine levels in chronic renal failure. N Engl J Med 317 (1987) 386
8. Stockenhuber F., Kurz R.W., Sertl K., Grimm G., and Balcke P. Increased plasma histamine levels in uraemic pruritus. Clin Sci (Lond) 79 (1990) 477-482
9. Jedras M., Zakrzewska-Pniewska B., Wardyn K., and Switalski M. Uremic neuropathy-Is uremic neuropathy related to patient age, duration of nephropathy and dialysis treatment?. Pol Arch Med Wewn 99 (1998) 452-461
10. Hiroshige K., Kabashima N., Takasugi M., and Kuroiwa A. Optimal dialysis improves uremic pruritus. Am J Kidney Dis 25 (1995) 413-419
11. Blachley J.D., Blankenship D.M., Menter A., Parker III T.F., and Knochel J.P. Uremic pruritus. Skin divalent ion content and response to ultraviolet phototherapy. Am J Kidney Dis 5 (1985) 237-241
12. Robertson K.E., and Mueller B.A. Uremic pruritus. Am J Health Syst Pharm 53 (1996) 2159-2170
13. Gao H., Zhang W., and Wang Y. Acupuncture treatment for 34 cases of uremic cutaneous pruritus. J Tradit Chin Med 22 (2002) 29-30
14. Giovannetti S., Barsotti G., Cupisti A., et al. Oral activated charcoal in patients with uremic pruritus. Nephron 70 (1995) 193-196
15. Russo G.E., Spaziani M., Guidotti C., et al. Pruritus in chronic uremic patients in periodic hemodialysis. Treatment with terfenadine. Minerva Urol Nefrol 38 (1986) 443-447
16. Tarng D.C., Cho Y.L., Liu H.N., and Huang T.P. Hemodialysis-related pruritus. A double-blind, placebo-controlled, crossover study of capsaicin 0.025% cream. Nephron 72 (1996) 617-622
17. Silverberg D.S., Iaina A., Reisin E., Rotzak R., and Eliahou H.E. Cholestyramine in uraemic pruritus. Br Med J 1 (1977) 752-753
18. Okada K., and Matsumoto K. Effect of skin care with an emollient containing a high water content on mild uremic pruritus. Ther Apher Dial 8 (2004) 419-422
19. Pascual J., Teruel J.L., and Ortuno J. Erythropoietin therapy for uremic pruritus. N Engl J Med 327 (1992) 734-735
20. Francos G.C., Kauh Y.C., Gittlen S.D., et al. Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. Int J Dermatol 30 (1991) 884-889
21. Andreassi M., Forleo P., Di Lorio A., Masci S., Abate G., and Amerio P. Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. J Int Med Res 25 (1997) 266-274
22. Gamma-linolenic acid (GLA). Altern Med Rev 9 (2004) 70-78
23. Tamimi N.A., Mikhail A.I., and Stevens P.E. Role of gamma-linolenic acid in uraemic pruritus. Nephron 83 (1999) 170-171
24. Szepietowski J.C., Sikora M., Kusztal M., Salomon J., Magott M., and Szepietowski T. Uremic pruritus. A clinical study of maintenance hemodialysis patients. J Dermatol 29 (2002) 621-627
25. Lehmacher W. Analysis of the crossover design in the presence of residual effects. Stat Med 10 (1991) 891-899
26. 1. Physiological significance and clinical use. Wien Klin Wochenschr 100 (1988) 471-477
27. Vassilopoulos D., Zurier R.B., Rossetti R.G., and Tsokos G.C. Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. Clin Immunol Immunopathol 83 (1997) 237-244
28. Horrobin D.F., and Morse P.F. Evening primrose oil and atopic eczema. Lancet 345 (1995) 260-261
29. Kleijnen J. Evening primrose oil. BMJ 309 (1994) 824-825
30. Fiocchi A., Sala M., Signoroni P., Banderali G., Agostoni C., and Riva E. The efficacy and safety of gamma-linolenic acid in the treatment of infantile atopic dermatitis. J Int Med Res 22 (1994) 24-32
31. Pereira B.J., and Dinarello C.A. Production of cytokines and cytokine inhibitory proteins in patients on dialysis. Nephrol Dial Transplant 9 suppl 2 (1994) S60-S71
32. Gaspari A.A., Lotze M.T., Rosenberg S.A., Stern J.B., and Katz S.I. Dermatologic changes associated with interleukin 2 administration. JAMA 258 (1987) 1624-1629
33. Wahlgren C.F., Tengvall Linder M., Hagermark O., and Scheynius A. Itch and inflammation induced by intradermally injected interleukin-2 in atopic dermatitis patients and healthy subjects. Arch Dermatol Res 287 (1995) 572-580
34. Stahle-Backdahl M. Uremic pruritus. Clinical and experimental studies. Acta Derm Venereol Suppl (Stockh) 145 (1989) S1-S38
35. Wahlgren C.F., Scheynius A., and Hagermark O. Antipruritic effect of oral cyclosporin A in atopic dermatitis. Acta Derm Venereol 70 (1990) 323-329
36. Sampaio E.P., Sarno E.N., Galilly R., Cohn Z.A., and Kaplan G. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 173 (1991) 699-703
37. Silva S.R., Viana P.C., Lugon N.V., Hoette M., Ruzany F., and Lugon J.R. Thalidomide for the treatment of uremic pruritus. A crossover randomized double-blind trial. Nephron 67 (1994) 270-273
38. Pauli-Magnus C., Klumpp S., Alscher D.M., Kuhlmann U., and Mettang T. Short-term efficacy of tacrolimus ointment in severe uremic pruritus. Perit Dial Int 20 (2000) 802-803
39. Iijima S., Otsuka F., Kikuchi H., et al. Oral supplementation with gamma-linolenic acid extracted from Mucor circinelloides improves the deformability of red blood cells in hemodialysis patients. Nephron 86 (2000) 122-128
40. Urbonas A., Schwartz R.A., and Szepietowski J.C. Uremic pruritus-An update. Am J Nephrol 21 (2001) 343-350
41. DeLuca P., Rothman D., and Zurier R.B. Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am 21 (1995) 759-777
42. Leventhal L.J., Boyce E.G., and Zurier R.B. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 119 (1993) 867-873
43. Zurier R.B., Rossetti R.G., Jacobson E.W., et al. Gamma-linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis Rheum 39 (1996) 1808-1817