The Gurnham equation in characterizing the compressibility of pharmaceutical materials

International Journal of Pharmaceutics

Volumn 317, Issue 2, 2006, Pages 109-113

  Zhao, J ^a   Burt, H M ^a   Miller, R A ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MPD Consulting   (Canada)

Author keywords

Compressibility; Compression; Gurnham equation; Heckel equation; Peak pressure; Porosity

Indexed keywords

CALCIUM CARBONATE; CALCIUM PHOSPHATE DIBASIC; CALESSENCE; ENDURANCE PLUS; EXCIPIENT; LACTOSE; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; STARCH;

ARTICLE; MATHEMATICAL MODEL; PHYSICAL CHEMISTRY; POROSITY; POWDER; PRESSURE GRADIENT; PRIORITY JOURNAL; TABLET COMPRESSION;

ACETAMINOPHEN; ALGORITHMS; CALCIUM PHOSPHATES; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DRUG COMPOUNDING; EXCIPIENTS; LACTOSE; PHARMACEUTICAL PREPARATIONS; POROSITY; POWDERS; PRESSURE; STARCH; TABLETS;

EID: 33745205073     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.02.054     Document Type: Article

References (14)

1. Celik M., and Marshall K. Use of a compaction simulator system in tableting research. Part I. Introduction to and experiments with the system. Drug Dev. Ind. Pharm. 15 (1989) 759-800
2. Celik M. Overview of compaction data analysis techniques. Drug Dev. Ind. Pharm. 18 (1992) 767-810
3. Dwivedi S.K., Oates R.J., and Mitchell A.G. Estimation of elastic recovery, work of decompression and Young's modulus using a rotary tablet press. J. Pharm. Pharmacol. 44 (1992) 459-466
4. Gurnham C.F., and Masson H.J. Expression of liquids from fibrous materials. Ind. Eng. Chem. 38 (1946) 1309-1315
5. Heckel R.W. An analysis of powder compaction phenomena. Trans. Metall. Soc. AIME 221 (1961) 1001-1008
6. Heckel R.W. Density-pressure relationships in powder compaction. Trans. Metall. Soc. AIME 221 (1961) 671-675
7. Miller, R.A., Yan, K.W., Oates, R.J., 2000. The compression of co-processed materials containing calcium carbonate and microcrystalline cellulose. AAPS Annual Meeting. Poster AM00-A-009281-AAPS.
8. Oates R.J., and Mitchell A.G. Calculation of punch displacement and work of powder compaction on a rotary tablet press. J. Pharm. Pharmacol. 41 (1989) 517-523
9. Oates R.J., and Mitchell A.G. Comparison of calculated and experimentally determined punch displacement on a rotary tablet press using both Manesty and IPT punches. J. Pharm. Pharmacol. 42 (1990) 388-396
10. Rowe R.C., and Roberts R.J. In: Alderborn G., and Nystrom C. (Eds). Mechanical Properties (1996), Marcel Dekker Inc., New York Basel 283-322
11. Rue P., and Rees J.E. Limitations of the Heckel relation for predicting powder compaction mechanisms. J. Pharm. Pharmacol. 30 (1978) 642
12. Sonnergaard J.M. A critical evaluation of the Heckel equation. Int. J. Pharm. 193 (1999) 63-71
13. Van der Voort Maarschalk K., Zuurman K., Vromans H., Bolhuis G.K., and Lerk C.F. Stress relaxation of compacts produced from viscoelastic materials. Int. J. Pharm. 151 (1997) 27-34
14. Zuurman K., Van der Voort Maarschalk K., and Bolhuis G.K. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties. Int. J. Pharm. 179 (1999) 107-115