Raloxifene treatment enhances brain activation during recognition of familiar items: A pharmacological fMRI study in healthy elderly males

Neuropsychopharmacology

Volumn 31, Issue 7, 2006, Pages 1508-1518

  Goekoop, Rutger ^a   Barkhof, Frederik ^a   Duschek, Erik J J ^a   Netelenbos, Coen ^a   Knol, Dirk L ^a   Scheltens, Philip ^a   Rombouts, Serge A R B ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

fMRI; Male; Memory; Raloxifene; Recognition; SERM

Indexed keywords

PLACEBO; RALOXIFENE;

ACCURACY; ADULT; AGED; AROUSAL; ARTICLE; BEHAVIOR; BRAIN FUNCTION; BRAIN SCINTISCANNING; CLINICAL TRIAL; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RESPONSE; ELECTROENCEPHALOGRAM; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; INFORMATION RETRIEVAL; LATENT PERIOD; MALE; MEMORY; MENTAL PERFORMANCE; NORMAL HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOGNITION; SCORING SYSTEM; VALIDATION PROCESS;

AGED; BRAIN; BRAIN MAPPING; DOUBLE-BLIND METHOD; ESTROGEN ANTAGONISTS; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MENTAL RECALL; MIDDLE AGED; OXYGEN; PATTERN RECOGNITION, VISUAL; RALOXIFENE; REACTION TIME; RECOGNITION (PSYCHOLOGY);

EID: 33745193912     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300956     Document Type: Article

References (44)

1. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR (Text Revision), 4th edn. American Psychiatric Association: Washington, DC. ISBN 0890420254.
2. Barrett-Connor E, Grady D, Sashegyi A, Anderson PW, Cox DA, Hoszowski K et al (2002). Raloxifene and cardiovascular events in osteoporotic postmenopausal women - four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial. JAMA 287: 847-857.
3. Bernardi F, Pluchino N, Stomati M, Pieri M, Genazzani AR (2003). CNS: sex steroids and SERMs. Ann NY Acad Sci 997: 378-388.
4. Bisagno V, Bowman RE, Luine VN (2003). Functional aspects of estrogen neuroprotection. Endocrine 21: 33-41.
5. Blum A, Hathaway L, Mincemoyer R, Schenke WH, Csako G, Waclawiw MA et al (2000). Hormonal, lipoprotein, and vascular effects of the selective estrogen receptor modulator raloxifene in hypercholesterolemic men. Am J Cardiol 85: 1491-1494.
6. Buckner RL, Koutstaal W, Schacter DL, Dale AM, Rotte M, Rosen BR (1998). Functional-anatomic study of episodic retrieval II - selective averaging of event-related fMRI trial to test the retrieval success hypothesis. Neuroimage 7: 163-175.
7. Buckner RL, Wheeler ME, Sheridan MA (2001). Encoding processes during retrieval tasks. J Cogn Neurosci 13: 406-415.
8. Cahill L (2003). Sex-related influences on the neurobiology of emotionally influenced memory. Amygdala Brain Funct: Basic Clin Approach 985: 163-173.
9. Cahill L, Alkire MT (2003). Epinephrine enhancement of human memory consolidation: interaction with arousal at encoding. Neurobiol Learn Mem 79: 194-198.
10. Corwin J (1994). On measuring discrimination and response bias: unequal numbers of targets and distractors and two classes of distractors. Neuropsychology 8: 110-117.
11. Coull JT (1998). Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Prog Neurobiol 55: 343-361.
12. Daselaar SM, Veltman DJ, Rombouts SARB, Raaijmakers JGW, Jonker C (2003). Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain 126: 43-56.
13. Doran PM, Riggs BL, Atkinson EJ, Khosla S (2001). Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men. J Bone Miner Res 16: 2118-2125.
14. Feenan K, Snodgrass JG (1990). The effect of context on discrimination and bias in recognition memory for pictures and words. Mem Cognit 18: 515-527.
15. Fletcher PC, Henson RNA (2001). Frontal lobes and human memory - insights from functional neuroimaging. Brain 124: 849-881.
16. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC (1995). Improved assessment of significant activation in functional magnetic-resonance- imaging (Fmri) - use of a cluster-size threshold. Magn Reson Med 33: 636-647.
17. Friston KJ, Worsley KJ, Frackowiak RSJ, Mazziotta JC, Evans A (1994). Assessing the significance of focal activations using their spatial extent. Hum Brain Mapp 1: 210-220.
18. Goekoop R, Duschek EJJ, Knol DL, Barkhof F, Netelenbos C, Scheltens P et al (2005). Raloxifene exposure enhances brain activation during memory performance in healthy elderly males; its possible relevance to behavior. Neuroimage 25: 63-75.
19. Heringa M (2003). Review on raloxifene: profile of a selective estrogen receptor modulator. Int J Clin Pharmacol Therap 41: 331-345.
20. Honey G, Bullmore E (2004). Human pharmacological MRI. Trends Pharmacol Sci 25: 366-374.
21. Jenkinson M, Bannister P, Brady M, Smith S (2002). Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17: 825-841.
22. Jenkinson M, Smith S (2001). A global optimisation method for robust affine registration of brain images. Med Image Anal 5: 143-156.
23. Korol DL (2004). Role of estrogen in balancing contributions from multiple memory systems. Neurobiol Learn Mem 82: 309-323.
24. Li CJ, Brake WG, Romeo RD, Dunlop JC, Gordon M, Buzescu R et al (2004). Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice. Proc Acad Natl Sci USA 101: 2185-2190.
25. Longcope C, Kato T, Horton R (1969). Conversion of blood androgens to estrogens in normal adult men and women. J Clin Invest 48: 2191-2201.
26. Maki PM, Resnick SM (2001). Effects of estrogen on patterns of brain activity at rest and during cognitive activity: a review of neuroimaging studies. Neuroimage 14: 789-801.
27. Morgan MA, Schulkin J, Pfaff DW (2004). Estrogens and non-reproductive behaviors related to activity and fear. Neurose Biobehav Rev 28: 55-63.
28. Reber PJ, Siwiec RM, Gitleman DR, Parrish TB, Mesulam MM, Paller KA (2002). Neural correlates of successful encoding identified using functional magnetic resonance imaging. J Neurosci 22: 9541-9548.
29. Rombouts SARB, Barkhof F, Witter MP, Machielsen WCM, Scheltens P (2001). Anterior medial temporal lobe activation during attempted retrieval of encoded visuospatial scenes: an event-related fMRI study. Neuroimage 14: 67-76.
30. Rugg MD, Otten LJ, Henson RNA (2002). The neural basis of episodic memory: evidence from functional neuroimaging. Phil Trans R Soc London B 357: 1097-1110.
31. Sarter M, Hasselmo ME, Bruno JP, Givens B (2005). Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. Brain Res Rev 48: 98-111.
32. Schacter DL, Wagner AD (1999). Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus 9: 7-24.
33. Smith SM (2002). Fast robust automated brain extraction. Hum Brain Mapp 17: 143-155.
34. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H et al (2004). Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23: S208-S219.
35. Talairach J, Tournoux P (1988). Co-Planar Stereotaxic Atlas of the Human Brain. Thieme Verlag: Stuttgart, Germany. ISBN 3137117011.
36. Thiel CM (2003). Cholinergic modulation of learning and memory in the human brain as detected with functional neuroimaging. Neurobiol Learn Mem 80: 234-244.
37. Wegesin DJ, Stern Y (2004). Inter- and intraindividual variability in recognition memory: effects of aging and estrogen use. Neuropsychology 18: 646-657.
38. Wilkinson D, Halligan P (2004). Opinion - the relevance of behavioural measures for functional-imaging studies of cognition. Nat Rev Neurosc 5: 67-73.
39. Wolf OT (2003). Cognitive functions and sex steroids. Ann D Endocrinol 64: 158-161.
40. Wolf OT, Preut R, Hellhammer DH, Kudielka BM, Schurmeyer TH, Kirschbaum C (2000). Testosterone and cognition in elderly men: a single testosterone injection blocks the practice effect in verbal fluency, but has no effect on spatial or verbal memory. Biol Psychiatry 47: 650-654.
41. Woolrich MW, Behrens TEJ, Beckmann CF, Jenkinson M, Smith SM (2004). Multilevel linear modelling for FMRI group analysis using Bayesian inference. Neuroimage 21: 1732-1747.
42. Woolrich MW, Ripley BD, Brady M, Smith SM (2001). Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage 14: 1370-1386.
43. Worsley KJ, Evans AC, Marrett S, Neelin P (1992). A 3-dimensional statistical-analysis for Cbf activation studies in human brain. J Cereb Blood Flow Metabol 12: 900-918.
44. Yaffe K, Krueger K, Cummings SR, Blackwell T, Henderson VW, Sarkar S et al (2005). Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the multiple outcomes of raloxifene evaluation (MORE) randomized trial. Am J Psychiatry 162: 683-690.