Pentoxifylline, a methyl xanthine derivative, reduces peritoneal adhesions and increases peritoneal fibrinolysis in rats

Tohoku Journal of Experimental Medicine

Volumn 209, Issue 3, 2006, Pages 249-255

  Tarhan, Omer Ridvan ^a,b   Barut, Ibrahim ^a   Sutcu, Recep ^a   Akdeniz, Yusuf ^a   Akturk, Onur ^a  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

PAI 1; Pentoxifylline; Peritoneal adhesion; Peritoneal fibrinolysis; tPA

Indexed keywords

HYDROXYPROLINE; METHYLXANTHINE DERIVATIVE; PENTOXIFYLLINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; TRENTAL AMPUL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VISCOSITY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOLYSIS; HISTOPATHOLOGY; NONHUMAN; PERITONEAL BIOPSY; PERITONEUM ADHESION; PROTEIN DETERMINATION; QUALITATIVE ANALYSIS; RAT; SCORING SYSTEM; TISSUE BLOOD FLOW;

ADHESIONS; ANIMALS; DRUG EVALUATION, PRECLINICAL; FEMALE; FIBRINOLYSIS; HYDROXYPROLINE; PENTOXIFYLLINE; PERITONEUM; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, WISTAR; TISSUE PLASMINOGEN ACTIVATOR;

EID: 33745188449     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.209.249     Document Type: Article

References (18)

1. Alkharfy, K.M., Kellum, J.A. & Matzke, G.R. (2000) Unintended immunomodulation: part II. Effects of pharmacological agents on cytokine activity. Shock, 13, 346-360.
2. Altuntas, I., Tarhan, O., Delibas, N., Cetin, R. & Sutcu, R. (2002) Seprafilm reduces adhesions to polypropylene mesh and increases peritoneal hydroxyproline. Am. Surg., 68, 759-761.
3. Becker, J.M. & Dayton, M.T. (1996) Prevention of postoperative abdominal adhesions by a sodium hyaluronatebioresorbable membrane: A prospective, randomized, double-blind multicenter study. J. Am. Coll. Surg., 183, 297-305.
4. Chalkiadakis, G.E., Kostakis, A., Karayannacos, P.E., Chalkiadakis, M.E., Sgouromali, S. & Giamarellou, H. (1985) Pentoxifylline in the treatment of experimental peritonitis in rats. Arch. Surg., 120, 1141-1144.
5. Evans, D.M., McAree, K., Guyton, D.P., Hawkins, N. & Stakleff, K. (1993) Dose dependency and wound healing aspects of the use of tissue plasminogen activator in the prevention of intra-abdominal adhesions. Am. J. Surg., 165, 229-232.
6. Holtz, G. (1984) Prevention and management of peritoneal adhesions. Fertil. Steril., 41, 497-507.
7. Ivarsson, M.L., Bergstrom, M., Eriksson, E., Risberg, B. & Holmdahl, L. (1998) Tissue markers as predictors of post-operative adhesions. Br. J. Surg., 85, 1549-1554.
8. Jarret, P.E., Moreland, M. & Browse, N.L. (1977) The effect of oxpentifylline ('Trental') on fibrinolytic activity and plasma fibrinogen levels. Curr. Med. Res. Opin., 4, 492-495.
9. Kaleli, B., Ozden, A., Aybek, Z. & Bostanci, B. (1998) The effect of L-arginine and pentoxifylline on postoperative adhesion formation. Acta Obstet. Gynecol. Scand., 77, 377-380.
10. Kelekci, S., Yilmaz, B., Oguz, S., Zergeroglu, S., Inan, I. & Tokucoglu, S. (2004) The efficacy of a hyaluronate/ carboxymethylcellulose membrane in prevention of post-operative adhesion in a rat uterine horn model. Tohoku J. Exp. Med., 204, 189-194.
11. Lai, H.S., Chu, S.Y., Chen, Y., Wu, C.H. & Lin, L.T. (1994) Effect of pentoxifylline on intraperitoneal adhesions after intestinal resection in rats. J. Formos. Med. Assoc., 93, 911-915.
12. Menzies, D. (2004) Adhesions: the cellular science. Hosp. Med., 65, 337-339.
13. Menzies, D. & Ellis, H. (1990) Intestinal obstruction from adhesions-how big is the problem? Ann. R. Coll. Surg. Engl., 72, 60-63.
14. Raftery, A.T. (1981) Effect of peritoneal trauma on peritoneal fibrinolytic activity and peritoneal adhesion formation. An experimental study in the rat. Eur. Surg. Res., 13, 397-401.
15. Schroer, R.H. (1985) Antithrombotic potential of pentoxifylline. A hemorheologically active drug. Angiology, 36, 387-398.
16. Steinleitner, A., Lambert, H., Kazensky, C., Danks, P. & Roy, S. (1990) Pentoxifylline, a methylxanthine derivative, prevents postsurgical adhesion reformation in rabbits. Obstet. Gynecol., 75, 926-928.
17. Tarhan, O.R., Eroglu, A., Cetin, R., Ynce, A., Bulbul, M. & Altuntas, Y.R. (2005) Effects of seprafilm on peritoneal fibrinolytic system. A. NZ J. Surg., 75, 690-692.
18. Woessner, J.B. (1961) The determination of hydroxiproline in tissue and protein samples containing small proportions of this imino acid. Arc. Biochem. Biophy., 93, 440-447.