Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: a potentially difficult distinction resolved by cytokeratin 5/6

Human Pathology

Volumn 37, Issue 7, 2006, Pages 787-793

  Rabban, Joseph T ^a   Koerner, Frederick C ^b   Lerwill, Melinda F ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Breast; Cytokeratin 5 6; Solid papillary ductal carcinoma in situ; Usual ductal hyperplasia

Indexed keywords

CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN ANTIBODY;

ARTICLE; BREAST CANCER; CELL HYPERPLASIA; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MYOEPITHELIUM CELL; PAPILLARY CARCINOMA; PROTEIN EXPRESSION; STAINING;

BREAST; BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARCINOMA, PAPILLARY; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; KERATINS; PRECANCEROUS CONDITIONS; TUMOR MARKERS, BIOLOGICAL;

EID: 33745178069     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2006.02.016     Document Type: Article

References (23)

1. Dickersin G.R., Maluf H.M., and Koerner F.C. Solid papillary carcinoma of breast: an ultrastructural study. Ultrastruct Pathol 21 (1997) 153-161
2. Maluf H.M., and Koerner F.C. Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. Am J Surg Pathol 19 (1995) 1237-1244
3. Azzopardi J.G., Muretto P., Goddeeris P., et al. 'Carcinoid' tumours of the breast: the morphological spectrum of argyrophil carcinomas. Histopathology 6 (1982) 549-569
4. Moll R., Franke W.W., Schiller D.L., et al. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31 (1982) 11-24
5. Bocker W., Bier B., Freytag G., et al. An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: normal breast and benign proliferative lesions. Virchows Arch A Pathol Anat Histopathol 421 (1992) 315-322
6. Bocker W., Bier B., Ludwig A., et al. Benign proliferative lesions and in situ carcinoma of the breast: new immunohistological findings and their biological implications. Eur J Cancer Prev 2 Suppl 3 (1993) 41-49
7. Bocker W., Moll R., Poremba C., et al. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest 82 (2002) 737-746
8. Jarasch E.D., Nagle R.B., Kaufmann M., et al. Differential diagnosis of benign epithelial proliferations and carcinomas of the breast using antibodies to cytokeratins. Hum Pathol 19 (1988) 276-289
9. Boecker W., Moll R., Dervan P., et al. Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. J Pathol 198 (2002) 458-467
10. Bratthauer G.L., Moinfar F., Stamatakos M.D., et al. Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias. Hum Pathol 33 (2002) 620-627
11. Dairkee S.H., Puett L., and Hackett A.J. Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. J Natl Cancer Inst 80 (1988) 691-695
12. Lacroix-Triki M., Mery E., Voigt J.J., et al. Value of cytokeratin 5/6 immunostaining using D5/16 B4 antibody in the spectrum of proliferative intraepithelial lesions of the breast. A comparative study with 34betaE12 antibody. Virchows Arch 442 (2003) 548-554
13. Moinfar F., Man Y.G., Lininger R.A., et al. Use of keratin 35betaE12 as an adjunct in the diagnosis of mammary intraepithelial neoplasia-ductal type-benign and malignant intraductal proliferations. Am J Surg Pathol 23 (1999) 1048-1058
14. Nagle R.B., Bocker W., Davis J.R., et al. Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. J Histochem Cytochem 34 (1986) 869-881
15. Otterbach F., Bankfalvi A., Bergner S., et al. Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology 37 (2000) 232-240
16. Raju U., Crissman J.D., Zarbo R.J., et al. Epitheliosis of the breast. An immunohistochemical characterization and comparison to malignant intraductal proliferations of the breast. Am J Surg Pathol 14 (1990) 939-947
17. Wetzels R.H., Kuijpers H.J., Lane E.B., et al. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol 138 (1991) 751-763
18. Bocker W., Bier B., Freytag G., et al. An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: epitheliosis and ductal carcinoma in situ. Virchows Arch A Pathol Anat Histopathol 421 (1992) 323-330
19. Boecker W. Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. J Pathol 195 (2001) 415-421
20. Raju U.B. Papillary neoplasia of the breast: immunohistochemically defined myoepithelial cells in the diagnosis of benign and malignant papillary breast neoplasms. Mod Pathol 2 (1989) 569-576
21. Tan P.H. Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ?. Am J Surg Pathol 29 (2005) 625-632
22. Tan P.H. Ductal carcinoma in situ with spindle cells: a potential diagnostic pitfall in the evaluation of breast lesions. Histopathology 45 (2004) 343-351
23. Papotti M. 34betaE12 cytokeratin immunodetection in the differential diagnosis of neuroendocrine carcinomas of the breast. Appl Immunohistochem Mol Morphol 9 (2001) 229-233