Safety of high-dose botulinum toxin type A therapy for the treatment of pediatric spasticity

Journal of Child Neurology

Volumn 21, Issue 3, 2006, Pages 189-192

  Goldstein, Edward M ^a  

^a Marcus Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; DIPHENHYDRAMINE;

ADOLESCENT; ADULT; BLADDER DISEASE; BODY WEIGHT; BOTULISM; CHILD; CHILD CARE; CLINICAL PROTOCOL; CONSTIPATION; DIPLOPIA; DOSE RESPONSE; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG SAFETY; DYSPHAGIA; ENTEROPATHY; ENURESIS; EYE MOVEMENT DISORDER; EYELID DISEASE; FALLING; FATIGUE; FLU LIKE SYNDROME; GASTROCNEMIUS MUSCLE; HAMSTRING; HUMAN; INJECTION PAIN; INJECTION SITE BLEEDING; INJECTION SITE INFECTION; LARYNX DISORDER; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; SOLEUS MUSCLE; SPASTICITY; WEAKNESS;

ADOLESCENT; ADULT; BOTULINUM TOXIN TYPE A; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFANT; INFANT, NEWBORN; LOWER EXTREMITY; MUSCLE SPASTICITY; NEUROMUSCULAR AGENTS; RETROSPECTIVE STUDIES; UPPER EXTREMITY;

EID: 33745175216     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.2310/7010.2006.00041     Document Type: Review

References (22)

1. Scott AB: Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology 1980;87: 1044-4049.
2. Tsui JKC, Eisen A, Stoessl AJ, et al: Double-blind study of botulinum toxin in spasmodic torticollis. Lancet 1986;2:245-247.
3. Boyd RN, Hays RM: Current evidence for the use of botulinum toxin type A in the management of children with cerebral palsy: A systematic review. Eur J Neurol 2001;8(Suppl 5):1-20.
4. Boyd RN, Morris ME, Graham HK Management of upper limb dysfunction in children with cerebral palsy: A systematic review. Eur J Neurol 2001;8(Suppl 5):150-166.
5. Goldstein EM: Spasticity management: An overview. J Child Neurol 2001;16:16-23.
6. Barwood S, Baillieu C, Boyd R, et al: Analgesic effects of botulinum toxin A: A randomized, placebo-controlled clinical trial. Dev Med Child Neurol 2000;42:116-121.
7. Koman LA, Mooney JF III, Smith BP, et al: Management of spasticity in cerebral palsy with botulinum-A toxin: Report of a preliminary, randomized, double-blind trial. J Pediatr Orthop 1994;14:299-303.
8. Koman LA, Mooney JF III, Smith BP, et al, Botox study group: Botulinum toxin type A neuromuscular blockade in the treatment of lower extremity spasticity in cerebral palsy: A randomized, double-blind, placebo-controlled trial. J Pediatr Orthop 2000;20: 108-115.
9. Love SC, Valentine JP, Blair EM, et al: The effect of botulinum toxin type A on the functional ability of the child with spastic hemiplegia in a randomized controlled trial. Eur J Neurol 2001;8(Suppl 5):50-58.
10. Sutherland DH, Kaufman KR, Wyatt MP, et al: Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy. Gait Posture 1999;10:1-9.
11. Koman LA, Brashear A, Rosenfeld S, et al: Botulinum toxin type A neuromuscular blockade in the treatment of equinus foot deformity in cerebral palsy: A multicenter, open-label clinical trial. Pediatrics 2001;108:1062-1071.
12. Scott AB, Suzuki D: Systemic toxicity of botulinum toxin by intramuscular injection in the monkey. Mov Disord 1988;3:333-335.
13. Koman LA, Mooney JF III, Smith B, et al: Management of cerebral palsy with botulinum-A toxin: Preliminary investigation. J Pediatr Orthop 1993;13:489-495.
14. Russman BS, Tilton A, Gormley ME Jr: Cerebral palsy: A rational approach to a treatment protocol, and the role of botulinum toxin in treatment. Muscle Nerve 1997;20(Suppl 6):S181-S193.
15. Delgado MR: The use of botulinum toxin type A in children with cerebral palsy: A retrospective study. Eur J Neurol 1999;6(Suppl 4):S11-S18.
16. Gormley ME, Gaebler-Spira D, Delgado M: Use of botulinum toxin type A in pediatric patients with cerebral palsy: A three-center retrospective chart review. J Child Neurol 2001;16:113-118.
17. Wissel J, Heinen F, Schenkel A, et al: Botulinum toxin A in the management of spastic gait disorders in children and young adults with cerebral palsy: A randomized, double-blind study of "high-dose" versus "low-dose" treatment. Neuropediatrics 1999;30:120-124.
18. Molenaers G, Desloovere K, Eymen M, et al: Botulium toxin type A treatment of cerebral palsy: An integrated approach. Eur J Neurol 1999;6(Suppl 4):S51-S57.
19. Desloovere K, Molenaers G, Jonkers I, et al: A randomized study of combined botulinum toxin type A and casting in the ambulant child with cerebral palsy using objective outcome measures. Eur J Neurol 2001;8(Suppl 5):75-87.
20. Fox C, Keet C, Strober J: Recent advances in infant botulism. Pediatr Neurol 2005;32:149-154.
21. Marks J: Medical aspects of biologic toxins. Anesthesiol Clin North Am 2004:22:509-532.
22. Flett PJ, Stern LM, Waddy H, et al: Botulinum toxin A versus fixed cast stretching for dynamic calf tightness in cerebral palsy. J Paediatr Child Health 1999;35:71-77.