Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core

Journal of Medicinal Chemistry

Volumn 49, Issue 12, 2006, Pages 3743-3747

  Frédérick, Raphaël ^a   Dumont, Willy ^a   Ooms, Frédéric ^a,d   Aschenbach, Lindsey ^b   Van Der Schyf, Cornelis J ^c   Castagnoli, Neal ^b   Wouters, Johan ^a   Krief, Alain ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d Euroscreen   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 TRIFLUOROMETHYL)PHENYL 7 METHOXY 5H INDENO[1,2 C]PYRIDAZIN 5 ONE; 3 (3 TRIFLUOROMETHYL)PHENYL 8 METHOXY 5H INDENO[1,2 C]PYRIDAZIN 5 ONE; AMINE OXIDASE (FLAVIN CONTAINING); HETEROCYCLIC COMPOUND; INDENE DERIVATIVE; MONOAMINE OXIDASE B INHIBITOR; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBICITY; INDENES; MITOCHONDRIA, LIVER; MOLECULAR STRUCTURE; MONOAMINE OXIDASE INHIBITORS; PYRIDAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745166940     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051091j     Document Type: Article

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