Kinase domain mutation of MAP2K4 is rare in gastric, colorectal and lung carcinomas [4]

Pathology

Volumn 38, Issue 3, 2006, Pages 263-264

  Lee, Jong Woo ^a   Soung, Young Hwa ^a   Kim, Su Young ^a   Nam, Suk Woo ^a   Park, Won Sang ^a   Lee, Jung Young ^a   Yoo, Nam Jin ^a   Lee, Sug Hyung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE 4;

CANCER THERAPY; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; COLORECTAL CARCINOMA; ENZYME ACTIVATION; EXON; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; HUMAN; INCIDENCE; LETTER; LUNG CARCINOMA; PROTEIN ANALYSIS; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STOMACH CARCINOMA; TUMOR CELL;

EID: 33745110497     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1080/00313020600699219     Document Type: Article

References (6)

1. Cuenda A. Mitogen-activated protein kinase kinase 4 (MKK4). Int J Biochem Cell Biol 2000; 32: 581-7.
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3. Davies H, Hunter C, Smith R, et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005; 65: 7591-5.
4. Stephens P, Edkins S, Davies H, et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 2005; 37: 590-2.
5. Chae KS, Ryu BK, Lee MG, Byun DS, Chi SG. Expression and mutation analyses of MKK4, a candidate tumour suppressor gene encoded by chromosome 17p, in human gastric adenocarcinoma. Eur J Cancer 2002; 38: 2048-57.
6. Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004; 4: 361-70.