Use of fish in vitro hepatocyte assays to detect multi-endpoint toxicity in Slovenian river sediments

Marine Environmental Research

Volumn 62, Issue SUPPL. 1, 2006, Pages

  Tollefsen, Knut Erik ^a   Bratsberg, Erling ^a   Bøyum, Olav ^a   Finne, Eivind Farmen ^a,b   Gregersen, Inger Katharina ^a,b   Hegseth, Marit ^b   Sandberg, Cecilie ^a   Hylland, Ketil ^a,b  

^a NORWEGIAN INSTITUTE FOR WATER RESEARCH   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Cytotoxicity; DNA damage; EROD; Estrogenicity; Fast Micromethod; Hepatocytes; Metabolic inhibition; Rainbow trout; Sediments

Indexed keywords

BIOASSAY; CYTOLOGY; GENETIC ENGINEERING; MIXTURES; ROBUSTNESS (CONTROL SYSTEMS); SEDIMENTS; TOXICITY;

7-ETHOXYRESORUFIN-O-DEETHYLASE (EROD); CYTOTOXICITY; DNA DAMAGE; ESTROGENICITY; FAST MICROMETHOD; HEPATOCYTES; METABOLIC INHIBITION; RAINBOW TROUT;

MARINE BIOLOGY;

ETHOXYRESORUFIN DEETHYLASE;

BIOASSAY; BIOMARKER; DNA; FISH; FLUVIAL DEPOSIT; TESTING METHOD; TOXICITY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ECOTOXICOLOGY; ENDOCRINE DISEASE; ENZYME ACTIVITY; ESTROGEN ACTIVITY; FISH; IN VITRO STUDY; LIVER CELL; MALE; METABOLIC INHIBITION; NONHUMAN; RAINBOW TROUT; RIVER; SEDIMENT; SLOVENIA; TOXICITY TESTING; VALIDATION PROCESS; WATER POLLUTION;

4-NITROQUINOLINE-1-OXIDE; ANIMALS; BIOLOGICAL ASSAY; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL MONITORING; GEOLOGIC SEDIMENTS; HEPATOCYTES; LETHAL DOSE 50; ONCORHYNCHUS MYKISS; PHENOLS; REPRODUCIBILITY OF RESULTS; SLOVENIA; TOXICITY TESTS; VITELLOGENESIS;

EURASIA; EUROPE; KRUPA RIVER; SAVA RIVER; SLOVENIA; SOUTHERN EUROPE;

ONCORHYNCHUS MYKISS;

EID: 33745109883     PISSN: 01411136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.marenvres.2006.04.025     Document Type: Article

References (10)

1. Castaño A., Bols N., Braunbeck T., Dierickx P., Halder M., Isomaa B., Kawahara K., Lee L.E.J., Mothersill C., Pärt P., Repetto G., Sintes J.R., Rufli H., Smith R., Wood C., and Segner H. Alternatives to Laboratory Animals 31 (2003) 317-351
2. Giergielewicz-Mozajska H., Dabrowski L., and Namiesnik J. Critical Reviews in Analytical Chemistry 31 (2001) 149-165
3. Klamer H.J.C., Leonards P.E.G., Lamoree M.H., Villerius L.A., Åkerman J.E., and Bakker J.F. Chemosphere 58 (2005) 1579-1587
4. Nebert D.W., Puga A., and Vasiliou V. Annuals of New York Academy of Sciences 685 (1993) 624-640
5. Polic S., Leskovsek H., and Horvat M. Acta Carsologica 29 (2000) 141-152
6. Sanchez-Fortun S., Llorente M.T., and Castano A. Aquatic Toxicology 73 (2005) 55-64
7. Scancar J., Milacic R., and Horvat M. Water, Air, and Soil Pollution 118 (1999) 87-99
8. Thomas K.V., Hurst M.R., Matthiessen P., and Waldock M.J. Environmental Toxicology and Chemistry 20 (2001) 2165-2170
9. Tollefsen K.-E., Mathisen R., and Stenersen J. Biomarkers 8 (2003) 394-407
10. Tollefsen, K.E., Goksøyr, A., Hylland, K., 2006. In: Hylland, K., Vethaak, A.D., Lang, T. (Eds.), Biological effects of contaminants in pelagic ecosystems, Society of Environmental Toxicology and Chemistry (SETAC), Brussels, Forthcoming.