메뉴 건너뛰기




Volumn 7, Issue 3, 2006, Pages 153-161

Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ADENOSINE TRIPHOSPHATE; CARNITINE; CEFDITOREN PIVOXIL; HEXOKINASE; PIVALIC ACID; PIVAMPICILLIN; SODIUM PIVALATE; UNCLASSIFIED DRUG;

EID: 33745106898     PISSN: 11745886     EISSN: 11745886     Source Type: Journal    
DOI: 10.2165/00126839-200607030-00002     Document Type: Review
Times cited : (15)

References (59)
  • 1
    • 0021024932 scopus 로고
    • Carnitine: Metabolism and functions
    • Bremer J. Carnitine: metabolism and functions. Physiol Rev 1983; 63: 1421-80
    • (1983) Physiol Rev , vol.63 , pp. 1421-1480
    • Bremer, J.1
  • 2
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005; 85: 1093-129
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 3
    • 0033983728 scopus 로고    scopus 로고
    • Cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine
    • Winter SC, Buist NR. Cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine. Am Heart J 2000; 139: S63-9
    • (2000) Am Heart J , vol.139
    • Winter, S.C.1    Buist, N.R.2
  • 4
    • 0019830914 scopus 로고
    • Systemic carnitine deficiency presenting as familial endocardial fibroelastosis
    • Tripp ME, Katcher ML, Peters HA, et al. Systemic carnitine deficiency presenting as familial endocardial fibroelastosis. N Engl J Med 1981; 305: 385-90
    • (1981) N Engl J Med , vol.305 , pp. 385-390
    • Tripp, M.E.1    Katcher, M.L.2    Peters, H.A.3
  • 5
    • 0019949555 scopus 로고
    • Carnitine deficiency presenting as familial cardiomyopathy: A treatable defect in carnitine transport
    • Waber LJ, Valle D, Neill C, et al. Carnitine deficiency presenting as familial cardiomyopathy: a treatable defect in carnitine transport. J Pediatr 1982; 101: 700-5
    • (1982) J Pediatr , vol.101 , pp. 700-705
    • Waber, L.J.1    Valle, D.2    Neill, C.3
  • 6
    • 0029812810 scopus 로고    scopus 로고
    • Endocardial fibroelastosis and primary carnitine deficiency due to a defect in the plasma membrane carnitine transport
    • Bennett MJ, Hale DE, Pollitt RJ, et al. Endocardial fibroelastosis and primary carnitine deficiency due to a defect in the plasma membrane carnitine transport. Clin Cardiol 1996; 19: 243-6
    • (1996) Clin Cardiol , vol.19 , pp. 243-246
    • Bennett, M.J.1    Hale, D.E.2    Pollitt, R.J.3
  • 7
    • 0028940682 scopus 로고
    • Reversible cardiomyopathy due to carnitine deficiency from renal tubular wasting
    • Zales VR, Benson Jr DW. Reversible cardiomyopathy due to carnitine deficiency from renal tubular wasting. Pediatr Cardiol 1995; 16: 288-92
    • (1995) Pediatr Cardiol , vol.16 , pp. 288-292
    • Zales, V.R.1    Benson Jr., D.W.2
  • 8
    • 0020540868 scopus 로고
    • Hypoglycemia, hepatic dysfunction, muscle weakness, cardiomyopathy, free carnitine deficiency and long-chain acylcarnitine excess responsive to medium chain triglyceride diet
    • Glasgow AM, Engel AG, Bier DM, et al. Hypoglycemia, hepatic dysfunction, muscle weakness, cardiomyopathy, free carnitine deficiency and long-chain acylcarnitine excess responsive to medium chain triglyceride diet. Pediatr Res 1983; 17: 319-26
    • (1983) Pediatr Res , vol.17 , pp. 319-326
    • Glasgow, A.M.1    Engel, A.G.2    Bier, D.M.3
  • 9
    • 0021042114 scopus 로고
    • Nearly fatal muscle carnitine deficiency with full recovery after replacement therapy
    • Prockop LD, Engel WK, Shug AL. Nearly fatal muscle carnitine deficiency with full recovery after replacement therapy. Neurology 1983; 33: 1629-31
    • (1983) Neurology , vol.33 , pp. 1629-1631
    • Prockop, L.D.1    Engel, W.K.2    Shug, A.L.3
  • 10
    • 0023951351 scopus 로고
    • Effect of concentration of carnitine on acetylcarnitine production in rat heart mitochondria oxidizing pyruvate
    • Lysiak W, Lilly K, Toth PP, et al. Effect of concentration of carnitine on acetylcarnitine production in rat heart mitochondria oxidizing pyruvate. Nutrition 1988; 4: 215-9
    • (1988) Nutrition , vol.4 , pp. 215-219
    • Lysiak, W.1    Lilly, K.2    Toth, P.P.3
  • 11
    • 0026728161 scopus 로고
    • Carnitine stimulation of glucose oxidation in the fatty acid-perfused isolated working rat heart
    • Broderick TL, Quinney HA, Lopaschuk GD. Carnitine stimulation of glucose oxidation in the fatty acid-perfused isolated working rat heart. J Biol Chem 1992; 267: 3758-63
    • (1992) J Biol Chem , vol.267 , pp. 3758-3763
    • Broderick, T.L.1    Quinney, H.A.2    Lopaschuk, G.D.3
  • 12
    • 0026648387 scopus 로고
    • Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children
    • Holme E, Jodal U, Linstedt S, et al. Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. Scand J Clin Lab Invest 1992; 52: 361-72
    • (1992) Scand J Clin Lab Invest , vol.52 , pp. 361-372
    • Holme, E.1    Jodal, U.2    Linstedt, S.3
  • 13
    • 0026451636 scopus 로고
    • Carnitine deficiency associated with long-term pivampicillin treatment: The effect of a replacement therapy regime
    • Rose SJ, Stokes TC, Patel S, et al. Carnitine deficiency associated with long-term pivampicillin treatment: the effect of a replacement therapy regime. Postgrad Med J 1992; 68: 932-4
    • (1992) Postgrad Med J , vol.68 , pp. 932-934
    • Rose, S.J.1    Stokes, T.C.2    Patel, S.3
  • 14
    • 0028238933 scopus 로고
    • Impaired keto-genesis in carnitine depletion caused by short-term administration of pivalic acid prodrug
    • Abrahamsson K, Eriksson BO, Holme E, et al. Impaired keto-genesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. Biochem Med Metab Biol 1994; 52: 18-21
    • (1994) Biochem Med Metab Biol , vol.52 , pp. 18-21
    • Abrahamsson, K.1    Eriksson, B.O.2    Holme, E.3
  • 15
    • 0024410225 scopus 로고
    • Carnitine deficiency induced by pivampicillin and pivmecillinam therapy
    • Holme E, Jacobson CE, Nordin I. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Lancet 1989; II: 469-72
    • (1989) Lancet , vol.2 , pp. 469-472
    • Holme, E.1    Jacobson, C.E.2    Nordin, I.3
  • 16
    • 0037385524 scopus 로고    scopus 로고
    • Impact on carnitine homeostasis of short-term treatment with pivalate prodrug cefditoren pivoxil
    • Brass EP, Mayer MD, Mulford DJ, et al. Impact on carnitine homeostasis of short-term treatment with pivalate prodrug cefditoren pivoxil. Clin Pharmacol Ther 2003; 73: 338-47
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 338-347
    • Brass, E.P.1    Mayer, M.D.2    Mulford, D.J.3
  • 17
    • 0036890172 scopus 로고    scopus 로고
    • Pivalate-generating prodrugs and carnitine homeostasis in man
    • Brass EP. Pivalate-generating prodrugs and carnitine homeostasis in man. Pharmacol Rev 2002; 54: 589-98
    • (2002) Pharmacol Rev , vol.54 , pp. 589-598
    • Brass, E.P.1
  • 18
    • 0022464411 scopus 로고
    • Carnitine metabolism and functions in humans
    • Rebouche CJ, Paulson DJ. Carnitine metabolism and functions in humans. Annu Rev Nutr 1986; 6: 41-66
    • (1986) Annu Rev Nutr , vol.6 , pp. 41-66
    • Rebouche, C.J.1    Paulson, D.J.2
  • 19
    • 0025101871 scopus 로고
    • Carnitine deficiency syndromes
    • Breningstall GN. Carnitine deficiency syndromes. Pediatr Neurol 1980; 6: 75-81
    • (1980) Pediatr Neurol , vol.6 , pp. 75-81
    • Breningstall, G.N.1
  • 20
    • 0025561023 scopus 로고
    • Primary and secondary disorders of carnitine metabolism
    • DeVivo DC, Tein I. Primary and secondary disorders of carnitine metabolism. Int Ped 1990; 5: 134-41
    • (1990) Int Ped , vol.5 , pp. 134-141
    • DeVivo, D.C.1    Tein, I.2
  • 21
    • 0020546217 scopus 로고
    • Carnitine metabolism and deficiency syndromes
    • Rebouche CJ, Engel AG. Carnitine metabolism and deficiency syndromes. Mayo Clin Proc 1983; 58: 533-40
    • (1983) Mayo Clin Proc , vol.58 , pp. 533-540
    • Rebouche, C.J.1    Engel, A.G.2
  • 22
    • 0027166659 scopus 로고
    • Carnitine metabolism and human carnitine deficiency
    • Tanphaichitr V, Leelehagul P. Carnitine metabolism and human carnitine deficiency. Nutrition 1993; 9: 246-54
    • (1993) Nutrition , vol.9 , pp. 246-254
    • Tanphaichitr, V.1    Leelehagul, P.2
  • 23
    • 0027055939 scopus 로고
    • Clinical and biochemical aspects of carnitine deficiency and insufficiency: Transport defects and inborn errors of b-oxidation
    • Angelini C, Vergani L, Martinuzzi A. Clinical and biochemical aspects of carnitine deficiency and insufficiency: transport defects and inborn errors of b-oxidation. Crit Rev Clin Lab Sci 1992; 29: 217-42
    • (1992) Crit Rev Clin Lab Sci , vol.29 , pp. 217-242
    • Angelini, C.1    Vergani, L.2    Martinuzzi, A.3
  • 24
    • 10644250580 scopus 로고    scopus 로고
    • Carnitine deficiency disorders in children
    • Stanley CA. Carnitine deficiency disorders in children. Ann N Y Acad Sci 2004; 1033: 42-51
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 42-51
    • Stanley, C.A.1
  • 25
    • 0029437586 scopus 로고
    • Carnitine disorders
    • Stanley CA. Carnitine disorders. Adv Pediatr 1995; 42: 209-42
    • (1995) Adv Pediatr , vol.42 , pp. 209-242
    • Stanley, C.A.1
  • 26
    • 0031868466 scopus 로고    scopus 로고
    • Genetic disorders of carnitine metabolism and their nutritional management
    • Kerner J, Hoppel C. Genetic disorders of carnitine metabolism and their nutritional management. Annu Rev Nutr 1998; 18: 179-206
    • (1998) Annu Rev Nutr , vol.18 , pp. 179-206
    • Kerner, J.1    Hoppel, C.2
  • 27
    • 0023475402 scopus 로고
    • Pivampicillin-promoted excretion of pivaloylcarnitine in humans
    • Melegh B, Kerner J, Bieber LL. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. Biochem Pharmacol 1987; 36: 3405-9
    • (1987) Biochem Pharmacol , vol.36 , pp. 3405-3409
    • Melegh, B.1    Kerner, J.2    Bieber, L.L.3
  • 28
    • 0029616748 scopus 로고
    • Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid
    • Abrahamsson K, Mellander M, Eriksson BO, et al. Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. Br Heart J 1995; 74: 656-9
    • (1995) Br Heart J , vol.74 , pp. 656-659
    • Abrahamsson, K.1    Mellander, M.2    Eriksson, B.O.3
  • 29
    • 0024410225 scopus 로고
    • Carnitine deficiency induced by pivampicillin and pivmecillinam therapy
    • Holme E, Greter J, Jacobson CE, et al. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Lancet 1989; 8661: 469-73
    • (1989) Lancet , vol.8661 , pp. 469-473
    • Holme, E.1    Greter, J.2    Jacobson, C.E.3
  • 30
    • 0030881785 scopus 로고    scopus 로고
    • Carnitine administration ameliorates the changes in energy metabolism caused by short-term pivampicillin medication
    • Melegh B, Pap M, Molnar D, et al. Carnitine administration ameliorates the changes in energy metabolism caused by short-term pivampicillin medication. Eur J Pediatr 1997; 156: 795-9
    • (1997) Eur J Pediatr , vol.156 , pp. 795-799
    • Melegh, B.1    Pap, M.2    Molnar, D.3
  • 31
    • 0026326851 scopus 로고
    • Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats
    • Bianchi PB, Davis AT. Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. J Nutr 1991; 121: 2029-36
    • (1991) J Nutr , vol.121 , pp. 2029-2036
    • Bianchi, P.B.1    Davis, A.T.2
  • 32
    • 0035076711 scopus 로고    scopus 로고
    • Effect of various levels of supplementation with sodium pivalate on tissue carnitine concentrations and urinary excretion of carnitine in the rat
    • Nelson HK, Lauber RP, Sheard NF. Effect of various levels of supplementation with sodium pivalate on tissue carnitine concentrations and urinary excretion of carnitine in the rat. J Nutr Biochem 2001; 12: 242-50
    • (2001) J Nutr Biochem , vol.12 , pp. 242-250
    • Nelson, H.K.1    Lauber, R.P.2    Sheard, N.F.3
  • 33
    • 0034767821 scopus 로고    scopus 로고
    • Short-term carnitine deficiency does not alter aerobic heart function but depresses reperfusion recovery after ischemia
    • Broderick TL, Cifuentes J, Green D, et al. Short-term carnitine deficiency does not alter aerobic heart function but depresses reperfusion recovery after ischemia. Can J Physiol Pharmacol 2001; 79: 892-7
    • (2001) Can J Physiol Pharmacol , vol.79 , pp. 892-897
    • Broderick, T.L.1    Cifuentes, J.2    Green, D.3
  • 34
    • 0017071784 scopus 로고
    • An improved and simplified radioisotopic assay for the determination of free and esterified carnitine
    • McGarry JD, Foster DW. An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J Lipid Res 1976; 17: 277-81
    • (1976) J Lipid Res , vol.17 , pp. 277-281
    • McGarry, J.D.1    Foster, D.W.2
  • 35
    • 0028877067 scopus 로고
    • Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation with out affecting cardiac functional capacity
    • Morris GS, Zhou Q, Wolf BA, et al. Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation with out affecting cardiac functional capacity. Life Sci 1995; 57: 2237-44
    • (1995) Life Sci , vol.57 , pp. 2237-2244
    • Morris, G.S.1    Zhou, Q.2    Wolf, B.A.3
  • 36
    • 0028951231 scopus 로고
    • Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency
    • Broderick TL, Wolf BA, Christos SC, et al. Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. Metabolism 1995; 44: 499-505
    • (1995) Metabolism , vol.44 , pp. 499-505
    • Broderick, T.L.1    Wolf, B.A.2    Christos, S.C.3
  • 37
    • 0029078844 scopus 로고
    • L-propionyl-carnitine effects on cardiac carnitine content and function in secondary carnitine deficiency
    • Broderick TL, DiDomenico D, Shug AL, et al. L-propionyl-carnitine effects on cardiac carnitine content and function in secondary carnitine deficiency. Can J Physiol Pharmacol 1995; 73: 509-14
    • (1995) Can J Physiol Pharmacol , vol.73 , pp. 509-514
    • Broderick, T.L.1    DiDomenico, D.2    Shug, A.L.3
  • 38
    • 0028886244 scopus 로고
    • L-Carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts
    • Broderick TL, Panagakis G, DiDomenico D, et al. L-Carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. Cardiovasc Res 1995; 30: 815-20
    • (1995) Cardiovasc Res , vol.30 , pp. 815-820
    • Broderick, T.L.1    Panagakis, G.2    DiDomenico, D.3
  • 39
    • 0023280511 scopus 로고
    • Changes in myosin isoenzymes, ATPase activity, and contraction duration in rat cardiac muscle with aging can be modulated by thyroxine
    • Effron MB, Bhatnagar GM, Spurgeon HA, et al. Changes in myosin isoenzymes, ATPase activity, and contraction duration in rat cardiac muscle with aging can be modulated by thyroxine. Circ Res 1987; 60: 238-45
    • (1987) Circ Res , vol.60 , pp. 238-245
    • Effron, M.B.1    Bhatnagar, G.M.2    Spurgeon, H.A.3
  • 40
    • 0022152098 scopus 로고
    • Abnormal cardiac biochemistry in spontaneously diabetic Bio-Breeding/Worcester rat
    • Malhotra A, Mordes JP, McDermott L, et al. Abnormal cardiac biochemistry in spontaneously diabetic Bio-Breeding/Worcester rat. Am J Physiol 1985; 249: H1051-5
    • (1985) Am J Physiol , vol.249
    • Malhotra, A.1    Mordes, J.P.2    McDermott, L.3
  • 41
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I, Yabuuchi H, Nezu J, et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 1997; 419: 107-11
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3
  • 42
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai I, Ohashi R, Nezu J, et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 1998; 273: 20378-82
    • (1998) J Biol Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3
  • 43
    • 0034948622 scopus 로고    scopus 로고
    • Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid
    • Okudaira N, Fujigaki M, Nakayoshi T, et al. Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid. Pharm Res 2001; 18: 439-45
    • (2001) Pharm Res , vol.18 , pp. 439-445
    • Okudaira, N.1    Fujigaki, M.2    Nakayoshi, T.3
  • 44
    • 0038042481 scopus 로고    scopus 로고
    • Carnitine transport: Pathophysiology and metabolism of known molecular effects
    • Tein I. Carnitine transport: pathophysiology and metabolism of known molecular effects. J Inherit Metab Dis 2003; 26: 147-69
    • (2003) J Inherit Metab Dis , vol.26 , pp. 147-169
    • Tein, I.1
  • 45
    • 10644229056 scopus 로고    scopus 로고
    • Kinetics, pharmacokinetics, and regulation of Lcarnitine and acetyl-L-carnitine metabolism
    • Rebouche CJ. Kinetics, pharmacokinetics, and regulation of Lcarnitine and acetyl-L-carnitine metabolism. Ann N Y Acad Sci 2004; 1033: 30-41
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 30-41
    • Rebouche, C.J.1
  • 46
    • 0027453493 scopus 로고
    • Acetyl CoA carboxylase regulation of fatty acid oxidation in the heart
    • Saddik M, Gamble J, Witters LA, et al. Acetyl CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 1993; 268: 25836-45
    • (1993) J Biol Chem , vol.268 , pp. 25836-25845
    • Saddik, M.1    Gamble, J.2    Witters, L.A.3
  • 47
    • 0019796279 scopus 로고
    • Tissue specific depletion of L-carnitine in rat heart and skeletal muscle by D-carnitine
    • Paulson DJ, Shug AL. Tissue specific depletion of L-carnitine in rat heart and skeletal muscle by D-carnitine. Life Sci 1981; 28: 2931-8
    • (1981) Life Sci , vol.28 , pp. 2931-2938
    • Paulson, D.J.1    Shug, A.L.2
  • 48
    • 0027411392 scopus 로고
    • Carnitine status during prolonged total parenteral nutrition
    • Heinonen OJ, Takala J. Carnitine status during prolonged total parenteral nutrition. J Pediatr 1993; 122: 503-4
    • (1993) J Pediatr , vol.122 , pp. 503-504
    • Heinonen, O.J.1    Takala, J.2
  • 49
    • 0029001125 scopus 로고
    • Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor
    • Tsoko M, Beauseigneur F, Gresti J, et al. Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor. Biochem Pharmacol 1995; 49: 1403-10
    • (1995) Biochem Pharmacol , vol.49 , pp. 1403-1410
    • Tsoko, M.1    Beauseigneur, F.2    Gresti, J.3
  • 50
    • 0026513892 scopus 로고
    • Prevalence of carnitine depletion in critically ill patients with undernutrition
    • Wennberg A, Hyltander A, Sjôberg Å, et al. Prevalence of carnitine depletion in critically ill patients with undernutrition. Metabolism 1992; 41: 165-71
    • (1992) Metabolism , vol.41 , pp. 165-171
    • Wennberg, A.1    Hyltander, A.2    Sjôberg, Å.3
  • 51
    • 0038026038 scopus 로고    scopus 로고
    • Myocardial function and energy production in carnitine-deficient rats
    • Zaugg CE, Spaniol M, Kaufmann P, et al. Myocardial function and energy production in carnitine-deficient rats. Cell Mol Life Sci 2003; 60: 767-75
    • (2003) Cell Mol Life Sci , vol.60 , pp. 767-775
    • Zaugg, C.E.1    Spaniol, M.2    Kaufmann, P.3
  • 53
    • 0023232325 scopus 로고
    • L-carnitine treatment improves cardiac performance and restores high energy phosphate pools in cardiomyopathic Syrian hamster
    • Whitmer JT. L-carnitine treatment improves cardiac performance and restores high energy phosphate pools in cardiomyopathic Syrian hamster. Circ Res 1987; 61: 396-408
    • (1987) Circ Res , vol.61 , pp. 396-408
    • Whitmer, J.T.1
  • 54
    • 0027232794 scopus 로고
    • Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency
    • Horiuchi M, Yoshida H, Kobayashi K, et al. Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency. FEBS Lett 1993; 326: 267-71
    • (1993) FEBS Lett , vol.326 , pp. 267-271
    • Horiuchi, M.1    Yoshida, H.2    Kobayashi, K.3
  • 55
    • 0028916973 scopus 로고
    • L-carnitine increases glucose oxidation and mechanical recovery in ischemic diabetic rat heart
    • Broderick TL, Quinney HA, Lopaschuk GD. L-carnitine increases glucose oxidation and mechanical recovery in ischemic diabetic rat heart. Cardiovasc Res 1995; 29: 373-8
    • (1995) Cardiovasc Res , vol.29 , pp. 373-378
    • Broderick, T.L.1    Quinney, H.A.2    Lopaschuk, G.D.3
  • 56
    • 84955835434 scopus 로고
    • Metabolic alterations in end-stage and less severe heart failure - Myocardial carnitine decrease
    • Regitz V, Bossaller C, Strasser R, et al. Metabolic alterations in end-stage and less severe heart failure - myocardial carnitine decrease. J Clin Chem Clin Biochem 1990; 28: 611-7
    • (1990) J Clin Chem Clin Biochem , vol.28 , pp. 611-617
    • Regitz, V.1    Bossaller, C.2    Strasser, R.3
  • 57
    • 0023855371 scopus 로고
    • Changes in tissue levels of carnitine during E. coli sepsis in the rat
    • Lanza-Jacoby S, Reibel DK. Changes in tissue levels of carnitine during E. coli sepsis in the rat. Circ Shock 1988; 24: 29-34
    • (1988) Circ Shock , vol.24 , pp. 29-34
    • Lanza-Jacoby, S.1    Reibel, D.K.2
  • 58
    • 0027463073 scopus 로고
    • Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation
    • Broderick TL, Quinney HA, Barker CC, et al. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation 1993; 87: 972-81
    • (1993) Circulation , vol.87 , pp. 972-981
    • Broderick, T.L.1    Quinney, H.A.2    Barker, C.C.3
  • 59
    • 0031884872 scopus 로고
    • Carnitine deficiency-induced cardiomyopathy
    • Paulson DJ. Carnitine deficiency-induced cardiomyopathy. Mol Cell Biochem 1988; 180: 33-41
    • (1988) Mol Cell Biochem , vol.180 , pp. 33-41
    • Paulson, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.