Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts

Archives of Physiology and Biochemistry

Volumn 112, Issue 1, 2006, Pages 31-36

  Marina Prendes, M ^a   Garcia J ^a   Testoni, G ^a   Fernandez M ^a   Perazzo, J ^a   Savino, E ^a   Varela, A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Dimethylamiloride; Fasting; Heart; Ischemia; Oxfenicine

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; ESTER DERIVATIVE; FATTY ACID; GLUCOSE; LACTIC ACID; LIPID; OXFENICINE; SODIUM PROTON EXCHANGE PROTEIN; TETRAZOLIUM;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; DIET RESTRICTION; DISEASE DURATION; ENERGY RESOURCE; ENZYME RELEASE; FATTY ACID OXIDATION; FEEDING; FEMALE; FUNCTIONAL ASSESSMENT; GLYCOLYSIS; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE CONTRACTURE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ENDDIASTOLIC PRESSURE; INHIBITION KINETICS; ISOLATED HEART; LIPOLYSIS; MALE; MEASUREMENT; NONHUMAN; PROTON SODIUM EXCHANGE; RAT; RAT STRAIN; REPERFUSION INJURY; STAINING; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

AMILORIDE; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CELL SURVIVAL; ENZYME INHIBITORS; FASTING; FATTY ACIDS; FEMALE; GLYCINE; GLYCOLYSIS; ION TRANSPORT; ISCHEMIC PRECONDITIONING, MYOCARDIAL; LACTIC ACID; LIPID METABOLISM; MALE; MUSCLE CELLS; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; OXIDATION-REDUCTION; RATS; RATS, WISTAR; REPERFUSION INJURY;

RATTUS NORVEGICUS;

EID: 33745106312     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.1080/13813450500500357     Document Type: Article

References (35)

1. Corr PB, Gross RW, Sobel BE. 1984. Amphipathic metabolites and membrane dysfunction in ischemic myicardium. Circ Res 55:135-54.
2. Dennis SC, Gevers W, Opie LH. 1991. Protons in ischemia: where do they come from, where do they go to? J Mol Cell Cardiol 23:1077-86.
3. Depre C, Taegtmeyer H. 2000. Metabolic aspects of programmed cell survival and cell death in the heart. Cardiovasc Res 45:538-48.
4. Goodwin GW, Taegtmeyer H. 1994. Metabolic recovery of isolated working rat heart after brief global ischemia. Am J Physiol 267:H462-70.
5. Idell-Wenger JA, Grotyohann LW, Neely JR. 1978. Coenzyme A and carnitine distribution in normal and ischemic hearts. J Biol Chem 253:4310-8.
6. Koike A, Akita T, Hotta Y, Takeya K, Kodama I, Murase M, Abe T, Toyama J. 1996. Protective effects of dimethylamiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. Thorac Cardiovasc Surg 112:765-75.
7. Kristiansen SB, Henning O, Nielsen-Kudsk JE, Botker HE, Nielsen TT. 2003. Effects of L-glutamate supplementation mimic effects of fasting in the ischemic heart. APMIS Suppl 109:117-21.
8. Lopaschuk GD, Saddik M. 1992. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia. Mol Cell Biochem 116:111-6.
9. Marina Prendes MG, Rastelli AH, Astudilla C, Fernández MA, Martinez M, Perazzo JC, Testoni G, Savino EA, Varela A. 2004. Influence of fasting on the effects of diazoxide in the ischemic-reperfused rat heart. J Physiol Bioch 60:51-8.
10. McNulty PH, Jagasia D, Whiting JM, Caulin-Glasser T. 2000. Effect of 6-week strogen withdrawal or replacement on myocardial ischemic tolerance in rats. Am J Physiol 278:H1030-4.
11. Mentzer RM, Lasley RD, Jessel A, Karmazyn M. 2003. Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection. Ann Thorac Surg 75:S700-8.
12. Molaparast-Saless FA, Liedtke AJ, Nelly SH. 1987. Effects of fatty acid blocking agents, oxfenicine and 4-romocrotonic acid, on performance in aerobic and ischemic myocardium. J Mol Cell Cardiol 19:509-29.
13. Montessuit C, Papageorgiou I, Tardy I, Lerch R. 1996. Effect of nutritional stage on substrate metabolism and contractile function in postischemic rat myocardium. Am J Physiol 271:H2060-70.
14. Montessuit C, Papageorgiou I, Tardy-Cantalupi I, Rosenblatt-Velin N, Lerch R. 2000. Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer. J Appl Physiol 89:111-9.
15. Murphy E, Perlman M, London RE, Steenbergen G. 1991. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ Res 68:1250-8.
16. Neely JR, Grotyohann LW. 1984. Role of glycolytic products in damage to ischemic myocardium. Circ Res 55:816-24.
17. + exchanger. J Biol Chem 273:6951-9.
18. Piper HM, Abdallah Y, Schäfer C. 2004. The first minutes of reperfusion: a window of opportunity for cardioprotection. Circ Res 61:365-71.
19. Ramasamy R, Liu H, Cherednichenko G, Schaefer S. 2001. Fasting limits the increase in intracellular calicium during ischemia in isolated rat hearts. Basic Res Cardiol 96:463-70.
20. Ruiz-Meana M, Garcia-Dorado D, Pina P, Inserte J, Agulló L, Soler-Soler J. 2003. Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. Am J Physiol 285:H999-1006.
21. Schaefer S, Ramasamy R. 1997. Glycogen utilization and ischemic injury in the isolated rat heart. Cardiovasc Res 35:90-8.
22. 2+ overload and acidosis. Am J Physiol 279:H2143-50.
23. Schneider CA, Taegtmeyer H. 1991. Fasting in vivo delays myocardial cell damage after brief periods of ischemia in the isolated working rat hearts. Circ Res 68:1045-50.
24. Schulz H. 1987. Inhibitors of fatty acid oxidation. Life Sci 40:1443-9.
25. Shimojo N, Fujino K, Kitahashi S, Nakao M, Naka K, Okuda K. 1991. Lactate analyzer with continuous blood sampling for monitoring blood lactate during physical exercise. Clin Chem 37:1978-80.
26. Shug AL, Thomsen JH, Folts JD, Bittar N, Klein ML, Koke JR, Huth PJ. 1978. Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia. Arch Biochem Biophys 187:25-33.
27. Stevens RM, Jahania MS, Mentzer RM, Lasley RD. 2004. Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning. Ann Thorac Surg 77:651-7.
28. 2+ overload and prolonged acidosis on reperfusion. Circulation 101:2749-57.
29. 2+ exchange. Circ Res 65:1045-56.
30. i and NADH with dysfunction after global ischemia in intact hearts. Am J Physiol 280:H280-93.
31. Varela A, Savino EA. 1988. Endogenous triacylglycerol utilization by the isolated rat atria. Rev Esp Fisiol 4:87-92.
32. Varela A, Carregal M, Espósito S, Bruno-Magnasco C, Savino EA. 1994. Beneficial effects of oxfenicine on the hypoxic rat atria. Arch Int Physiol Biochem Biophys 102:125-8.
33. Varela A, Carregal M, Testoni G, Dalamon V, Savino EA. 1997. Effects of fasting, hypoxia, methylpalmoxirate and oxfenicine on the tissue-levels of long-chain acyl-CoA and acylcarnitine in the rat atria. Arch Physiol Biochem 105:1-5.
34. Varela A, Dalamon V, Testoni G, Carregal M, Cerruti S, Savino EA. 1999. Effects of pentanoate, 4-pentenoate, 3-hydroxybutirate and insulin on the tissue-levels of long-chain acyl Coa and acylcarnitine in the oxygenated and hypoxic rat atria. Arch Physiol Biochem 107:22-6.
35. Varela A, Marina Prendes MG, Testoni G, Vázquez N, Astudilla C, Cerruti S, Savino EA. 2002. Influence of fasting on the effects of ischemic preconditioning in the ischemic-reperfused rat heart. Arch Physiol Biochem 110:189-96.