Artificial neural network classifier for the diagnosis of Parkinson's disease using [99mTc]TRODAT-1 and SPECT

Physics in Medicine and Biology

Volumn 51, Issue 12, 2006, Pages 3057-3066

  Acton, Paul D ^a   Newberg, Andrew ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DATA REDUCTION; DISEASE CONTROL; IMAGING SYSTEMS; NEUROLOGY; NUCLEAR MEDICINE; PATIENT MONITORING; POSITRON EMISSION TOMOGRAPHY;

DOPAMINERGIC NEUROTRANSMITTER; LEAVE ONE OUT; PARKINSON'S DISEASE (PD); PIXELS;

NEURAL NETWORKS;

[2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M; DOPAMINE TRANSPORTER; TRACER;

ADULT; AGED; ARTICLE; ARTIFICIAL NEURAL NETWORK; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DATA ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; NEUROIMAGING; PARKINSON DISEASE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; ARTIFICIAL INTELLIGENCE; CLUSTER ANALYSIS; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; NEURAL NETWORKS (COMPUTER); ORGANOTECHNETIUM COMPOUNDS; PARKINSON DISEASE; PATTERN RECOGNITION, AUTOMATED; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 33745100001     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/51/12/004     Document Type: Article

References (27)

1. Acton P D 2004 Bioimaging in Neurodegeneration ed P A Broderick (Totowa, NJ: Humana Press)
2. 99mTc]TRODAT-1 binding to dopamine transporters in non-human primates using SPET Eur. J. Nucl. Med. 26 518-26
3. 99mTc]TRODAT-1 and single photon emission tomography Eur. J. Nucl. Med. 27 1714-8
4. Acton P D and Mozley P D 2000 Single photon emission tomography imaging in Parkinsonian disorders: a review Behav. Neurol. 12 11-27
5. Acton P D, Mozley P D and Kung H F 1999b Logistic discriminant parametric mapping: a novel method for the pixel-based differential diagnosis of Parkinson's disease Eur. J. Nucl. Med. 26 1413-23
6. 99mTc]TRODAT-1 and SPECT Phys. Med. Biol. 51 575-85
7. 123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease J. Neurol. Neurosurg. Psychiatry 62 133-40
8. Booij J, Tissingh G, Winogrodzka A and Royen E A 1999 Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with Parkinsonism Eur. J. Nucl. Med. 26 171-82
9. 99mTc-ECD brain perfusion SPET allows accurate differentiation between healthy volunteers, multiple system atrophy and idiopathic Parkinson's disease Eur. J. Nucl. Med. 30 16-24
10. 99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease Parkinsonism Relat. Disord. 10 375-9
11. Efron B 1983 Estimating the error rate of a prediction rule: improvements on cross-validation J. Am. Stat. Assoc. 78 316-31
12. Freeman J and Skarpura D 1991 Neural Networks-Algorithms, Applications, and Programming Techniques (Reading, MA: Addison-Wesley)
13. Friston K J, Ashburner J, Frith C D, Poline J B, Heather J D and Frackowiak R S J 1995a Spatial registration and normalisation of images. Hum. Brain Mapp. 2 165-89
14. Friston K J, Holmes A P, Worsley K J, Poline J P, Frith C D and Frackowiak R S J 1995b Statistical parametric maps in functional imaging: a general linear approach Hum. Brain Mapp. 2 189-210
15. Hughes A J, Daniel S E, Kilford L and Lees A J 1992 Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases J. Neurol. Neurosurg. Psychiatry 55 181-4
16. Innis R B et al 1993 Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease Proc. Natl Acad. Sci. USA 90 11965-9
17. Lee J S, Lee D S, Kim S K, Lee S K, Chung J K, Lee M C and Park K S 2000 Localization of epileptogenic zones in F-18 FDG brain PET of patients with temporal lobe epilepsy using artificial neural network IEEE Trans. Med. Imaging 19 347-55
18. Mozley P D, Acton P D, Barraclough E D, Plossl K, Gur R C, Mathur A, Alavi A, Saffer J and Kung H F 1999 Effects of age on the cerebral distribution of [Tc-99m]TRODAT-1 in healthy humans J. Nucl. Med. 40 1812-7
19. Mozley P D, Schneider J S, Acton P D, Barraclough E D, Stern M B, Plossl K, Alavi A and Kung H F 2000 Binding of [Tc-99m]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and healthy volunteers J. Nucl. Med. 41 584-9
20. Parker J R 1997 Algorithms for Image Processing and Computer Vision (New York: Wiley)
21. Seibyl J P, Innis R B, Early M L, Fussell B A and Marek K 1999 Baseline striatal dopamine transporter uptake measured with [I-123]beta-CIT may predict the rate of disease progression in idiopathic Parkinson's disease J. Nucl. Med. 5 (Suppl.) 27P
22. Shen S, Sandham W, Granat M and Sterr A 2005 MRI fuzzy segmentation of brain tissue using neigborhood attraction with neural network optimization IEEE Trans. Inf. Technol. Biomed. 9 459-67
23. 99mTc]TRODAT-1 SPECT binding to dopamine transporters in patients with multiple system atrophy and Parkinson's disease Eur. J. Nucl. Med. 32 302-7
24. Szabo B K, Wiberg M K, Bone B and Aspelin P 2004 Application of artificial neural networks to the analysis of dynamic MR imaging features of the breast Eur. Radiol. 14 1217-25
25. Tatsch K 2001 Imaging of the dopaminergic system in Parkinsonism with SPET Nucl. Med. Commun. 22 819-27
26. 99mTc-TRODAT-1 Eur. J. Nucl. Med. 31 1119-27
27. Wagenknecht G, Kaiser H J, Buell U and Sabri O 2004 MRI-based individual 3D region-of-interest atlases of the human brain: a new method for analyzing functional data Methods Inf. Med. 43 383-90