Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels

FEMS Immunology and Medical Microbiology

Volumn 47, Issue 2, 2006, Pages 296-301

  Wieland, Hagen ^a,b   Hechtel, Nicole ^b   Faigle, Marion ^b   Neumeister, Birgid ^b,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c SYNLAB ACADEMY   (Germany)

Author keywords

Human monocyte; Intracellular multiplication; L type calcium channel; Legionella pneumophila

Indexed keywords

2,3 BIS(4 HYDROXYPHENYL)PROPIONITRILE; ANTIESTROGEN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; DAIDZEIN; DANTROLENE; FULVESTRANT; GENISTEIN; HERBIMYCIN; NIFEDIPINE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TAMOXIFEN; UNCLASSIFIED DRUG; VERAPAMIL;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL REPRODUCTION; CONTROLLED STUDY; ENZYME INHIBITION; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; NONHUMAN; PRIORITY JOURNAL;

CALCIUM; CALCIUM CHANNELS, L-TYPE; ESTROGEN RECEPTOR MODULATORS; GENISTEIN; HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MONOCYTES; PROTEIN-TYROSINE KINASES;

EID: 33745098274     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2006.00092.x     Document Type: Article

References (23)

1. Akiyama T Ishida J Nakagawa S Ogawara H Watanabe S Itoh N Shibuya M Fukami Y ( 1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262 : 5592 5595.
2. Azenabor AA Chaudhry AU ( 2003) Effective macrophage redox defense against Chlamydia pneumoniae depends on L-type Ca2+ channel activation. Med Microbiol Immunol 192 : 99 106.
3. Azenabor AA Chaudhry AU Yang S ( 2003) Macrophage L-type Ca2+ channel antagonists alter Chlamydia pneumoniae MOMP and HSP-60 mRNA gene expression, and improve antibiotic susceptibility. Immunobiology 207 : 237 245.
4. Christensen KA Myers JT Swanson JA ( 2002) pH-dependent regulation of lysosomal calcium in macrophages. J Cell Sci 115 : 599 607.
5. Dorn BR Dunn WA Jr. Progulske-Fox A ( 2002) Bacterial interactions with the autophagic pathway. Cell Microbiol 4 : 1 10.
6. Fields BS Barbaree JM Shotts EB Feeley JC Morrill WE Sanden GN Dykstra MJ ( 1986) Comparison of guinea pig and protozoan models for determining virulence of Legionella species. Infect Immun 53 : 553 559.
7. Horwitz MA Maxfield FR ( 1984) Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol 99 : 1936 1943.
8. Horwitz MA Silverstein SC ( 1980) Legionnaires' disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes. J Clin Invest 66 : 441 450.
9. Kohler R Bubert A Goebel W Steinert M Hacker J Bubert B ( 2000) Expression and use of the green fluorescent protein as a reporter system in Legionella pneumophila. Mol Gen Genet 262 : 1060 1069.
10. Lambert KC Curran EM Judy BM Lubahn DB Estes DM ( 2004) Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitro. J Leukoc Biol 75 : 1166 1172.
11. Malik ZA Denning GM Kusner DJ ( 2000) Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages. J Exp Med 191 : 287 302.
12. Neumeister B Schoniger S Faigle M Eichner M Dietz K ( 1997) Multiplication of different Legionella species in Mono Mac 6 cells and in Acanthamoeba castellanii. Appl Environ Microbiol 63 : 1219 1224.
13. Rowbotham TJ ( 1980) Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae. J Clin Pathol 33 : 1179 1183.
14. Rowbotham TJ ( 1981) Pontiac fever, amoebae, and legionellae. Lancet 1 : 40 41.
15. Stober CB Lammas DA Li CM Kumararatne DS Lightman SL Mc Ardle CA ( 2001) ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guerin within human macrophages is calcium dependent and associated with the acidification of mycobacteria-containing phagosomes. J Immunol 166 : 6276 6286.
16. Sturgill-Koszycki S Swanson MS ( 2000) Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. J Exp Med 192 : 1261 1272.
17. Susa M Marre R ( 1999) Legionella pneumophila invasion of MRC-5 cells induces tyrosine protein phosphorylation. Infect Immun 67 : 4490 4498.
18. Vieira OV Botelho RJ Grinstein S ( 2002) Phagosome maturation: aging gracefully. Biochem J 366 : 689 704.
19. Wang TT Sathyamoorthy N Phang JM ( 1996) Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis 17 : 271 275.
20. Wieland H Goetz F Neumeister B ( 2004) Phagosomal acidification is not a prerequisite for intracellular multiplication of Legionella pneumophila in human monocytes. J Infect Dis 189 : 1610 1614.
21. Wilsson A Lundqvist H Gustafsson M Stendahl O ( 1996) Killing of phagocytosed Staphylococcus aureus by human neutrophils requires intracellular free calcium. J Leukoc Biol 59 : 902 907.
22. Yokoshiki H Sumii K Sperelakis N ( 1996) Inhibition of L-type calcium current in rat ventricular cells by the tyrosine kinase inhibitor, genistein and its inactive analog, daidzein. J Mol Cell Cardiol 28 : 807 814.
23. Ziegler-Heitbrock HW Thiel E Futterer A Herzog V Wirtz A Riethmuller G ( 1988) Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int J Cancer 41 : 456 461.