-
6
-
-
0032080854
-
A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy
-
Carron C.P. Meyer D.M. Pegg J.A. Engleman V.W. Nickols M.A. Settle S.L. Westlin W.F. Ruminski P.G. Nickols G.A. ( 1998) A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res 58 : 1930 1935.
-
(1998)
Cancer Res
, vol.58
, pp. 1930-1935
-
-
Carron, C.P.1
Meyer, D.M.2
Pegg, J.A.3
Engleman, V.W.4
Nickols, M.A.5
Settle, S.L.6
Westlin, W.F.7
Ruminski, P.G.8
Nickols, G.A.9
-
7
-
-
0035266184
-
3 and αvβ5 integrin receptor antagonist
-
3 and αvβ5 integrin receptor antagonist. Cancer Res 61 : 2232 2238.
-
(2001)
Cancer Res
, vol.61
, pp. 2232-2238
-
-
Kumar, C.C.1
Malkowski, M.2
-
8
-
-
0036904072
-
The αv integrin antagonists as novel anticancer agents: An update
-
Kerr J.S. Slee A.M. Mousa S.A. ( 2002) The αv integrin antagonists as novel anticancer agents: an update. Expert Opin Investig Drugs 11 : 1765 1774.
-
(2002)
Expert Opin Investig Drugs
, vol.11
, pp. 1765-1774
-
-
Kerr, J.S.1
Slee, A.M.2
Mousa, S.A.3
-
9
-
-
0031911347
-
Mechanisms of angiogenesis in vascular disorders: Potential therapeutic targets
-
Mousa S.A. ( 1998) Mechanisms of angiogenesis in vascular disorders: potential therapeutic targets. Drugs Future 23 : 51 60.
-
(1998)
Drugs Future
, vol.23
, pp. 51-60
-
-
Mousa, S.A.1
-
10
-
-
0032710319
-
Clinical applications of angiogenic growth factors and their inhibitors
-
Ferrara N. Alitalo K. ( 1999) Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 5 : 1359 1364.
-
(1999)
Nat Med
, vol.5
, pp. 1359-1364
-
-
Ferrara, N.1
Alitalo, K.2
-
11
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P. Jain R.K. ( 2000) Angiogenesis in cancer and other diseases. Nature 407 : 249 257.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
13
-
-
0036734093
-
A reevaluation of integrins as regulators of angiogenesis
-
Hynes R.O. ( 2002) A reevaluation of integrins as regulators of angiogenesis. Nat Med 8 : 918 921.
-
(2002)
Nat Med
, vol.8
, pp. 918-921
-
-
Hynes, R.O.1
-
14
-
-
0037728975
-
3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice
-
3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice. Cancer Res 63 : 2079 2087.
-
(2003)
Cancer Res
, vol.63
, pp. 2079-2087
-
-
Reinmuth, N.1
Liu, W.2
Ahmad, S.A.3
Fan, F.4
Stoeltzing, O.5
Parikh, A.A.6
Bucana, D.C.7
Gallick, G.E.8
Nickols, M.A.9
Westlin, W.F.10
Ellis, L.M.11
-
15
-
-
33745102638
-
-
Abstracts of Papers - 221st American Chemical Society, National Meeting, San Diego, CA, USA, April 1-5, 2001; MEDI-225.
-
3as Tumor Angiogenesis Inhibitors: the Discovery of the S257-class of Integrin Antagonist. Abstracts of Papers - 221st American Chemical Society, National Meeting, San Diego, CA, USA, April 1-5, 2001; MEDI-225.
-
(2001)
3as Tumor Angiogenesis Inhibitors: The Discovery of the S257-class of Integrin Antagonist.
-
-
Rogers, T.E.1
Ruminski, P.G.2
Rico, J.G.3
Lu, H.-F.4
Colson, P.J.5
Awasthi, A.K.6
Nagarajan, S.R.7
Devadas, B.8
Malecha, J.W.9
Chandrakumar, N.S.10
Nickols, G.A.11
Westlin, W.F.12
Meyer, D.M.13
Keene, J.L.14
Settle, S.L.15
Carron, C.P.16
Engleman, V.W.17
Freeman, S.K.18
Shannon, K.E.19
Knoerzer, D.L.20
Westlin, M.M.21
Nickols, M.A.22
more..
-
16
-
-
33745109802
-
-
Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, USA, March 26-30, 2000; MEDI-295.
-
3 Integrin Receptor as Inhibitors of Angiogenesis and their Efficacy in Preclinical Animal Models of Cancer. Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, USA, March 26-30, 2000; MEDI-295.
-
(2000)
3 Integrin Receptor As Inhibitors of Angiogenesis and Their Efficacy in Preclinical Animal Models of Cancer.
-
-
Ruminski, P.G.1
Rogers, T.E.2
Rico, J.G.3
Nickols, G.A.4
Westlin, W.F.5
Engleman, V.W.6
Settle, S.L.7
Keene, J.L.8
Freeman, S.K.9
Carron, C.P.10
Meyer, D.M.11
-
17
-
-
33745100982
-
-
Book of Abstracts, 218th ACS National Meeting, New Orleans, LA, USA, August 22-26, 1999; MEDI-169.
-
3 Integrin Receptor and their in vivo Efficacy in Animal Models of Cancer. Book of Abstracts, 218th ACS National Meeting, New Orleans, LA, USA, August 22-26, 1999; MEDI-169.
-
(1999)
3 Integrin Receptor and Their in Vivo Efficacy in Animal Models of Cancer.
-
-
Ruminski, P.G.1
Rogers, T.E.2
Rico, J.G.3
Nickols, G.A.4
Westlin, W.F.5
Engleman, V.W.6
Settle, S.L.7
Keene, J.L.8
Freeman, S.K.9
Carron, C.P.10
Meyer, D.M.11
-
19
-
-
0024059120
-
Novel purification of vitronectin from human plasma by heparin affinity chromatography
-
Yatohgo T. Izumi M. Kashiwagi H. Hayashi M. ( 1988) Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct Funct 13 : 281 292.
-
(1988)
Cell Struct Funct
, vol.13
, pp. 281-292
-
-
Yatohgo, T.1
Izumi, M.2
Kashiwagi, H.3
Hayashi, M.4
-
20
-
-
0030924375
-
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo
-
Engleman V.W. Nickols G.A. Ross F.P. Horton M.A. Griggs D.W. Settle S.L. Ruminski P.G. Teitelbaum S.L. ( 1997) A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest 99 : 2284 2292.
-
(1997)
J Clin Invest
, vol.99
, pp. 2284-2292
-
-
Engleman, V.W.1
Nickols, G.A.2
Ross, F.P.3
Horton, M.A.4
Griggs, D.W.5
Settle, S.L.6
Ruminski, P.G.7
Teitelbaum, S.L.8
-
21
-
-
0037192933
-
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1
-
Mu D. Cambier S. Fjellbirkeland L. Baron J.L. Munger J.S. Kawakatsu H. Sheppard D. Broaddus V.C. Nishimura S.L. ( 2002) The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1. J Cell Biol 157 : 493 507.
-
(2002)
J Cell Biol
, vol.157
, pp. 493-507
-
-
Mu, D.1
Cambier, S.2
Fjellbirkeland, L.3
Baron, J.L.4
Munger, J.S.5
Kawakatsu, H.6
Sheppard, D.7
Broaddus, V.C.8
Nishimura, S.L.9
-
22
-
-
33745088545
-
-
US Patent No. 5,633,272.
-
Talley J.J. Brown D.L. Nagarajan S. Carter J.S. Weier R.M. Stealey M.A. Collins P.W. Rogers R.S. Seibert K. ( 1997) Substituted Isoxazoles for the Treatment of Inflammation. US Patent No. 5,633,272.
-
(1997)
Substituted Isoxazoles for the Treatment of Inflammation.
-
-
Talley, J.J.1
Brown, D.L.2
Nagarajan, S.3
Carter, J.S.4
Weier, R.M.5
Stealey, M.A.6
Collins, P.W.7
Rogers, R.S.8
Seibert, K.9
-
23
-
-
33847085007
-
Hard acid and soft nucleophile system: 2. Demethylation of methyl ethers of alcohol and phenol with aluminum halide-phenol system
-
Node M. Nishide K. Fuji K. Fujita E. ( 1980) Hard acid and soft nucleophile system: 2. Demethylation of methyl ethers of alcohol and phenol with aluminum halide-phenol system. J Org Chem 45 : 4275 4277.
-
(1980)
J Org Chem
, vol.45
, pp. 4275-4277
-
-
Node, M.1
Nishide, K.2
Fuji, K.3
Fujita, E.4
-
24
-
-
0033526891
-
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
-
Miller W.H. Bondinell W.E. Cousins R.D. Erhard K.F. Jakas D.R. Keenan R.M. Ku T.W. Newlander K.A. Ross S.T. Haltiwanger R.C. Bradbeer J. Drake F.H. Gowen M. Hoffman S.J. Hwang S-M. et al. ( 1999) Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. Bioorg Med Chem Lett 9 : 1807 1812.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 1807-1812
-
-
Miller, W.H.1
Bondinell, W.E.2
Cousins, R.D.3
Erhard, K.F.4
Jakas, D.R.5
Keenan, R.M.6
Ku, T.W.7
Newlander, K.A.8
Ross, S.T.9
Haltiwanger, R.C.10
Bradbeer, J.11
Drake, F.H.12
Gowen, M.13
Hoffman, S.J.14
Hwang, S.-M.15
-
26
-
-
0037451878
-
3) antagonists
-
3) antagonists. Bioorg Med Chem Lett 13 : 1483 1486.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 1483-1486
-
-
Miller, W.H.1
Manley, P.J.2
Cousins, R.D.3
Erhard, K.F.4
Heerding, D.A.5
Kwon, C.6
Ross, S.R.7
Samanen, J.M.8
Takata, D.T.9
Uzinskas, I.N.10
Yuan, C.C.K.11
Haltiwanger, R.C.12
Gress, C.J.13
Lark, M.W.14
Hwang, S.-M.15
-
28
-
-
0000409526
-
Facile synthesis of 2-aminonicotinaldehyde
-
Moormann A.E. Yen C.H. Yu S. ( 1987) Facile synthesis of 2-aminonicotinaldehyde. Synth Commun 17 : 1695 1699.
-
(1987)
Synth Commun
, vol.17
, pp. 1695-1699
-
-
Moormann, A.E.1
Yen, C.H.2
Yu, S.3
-
29
-
-
33745069500
-
-
International Patent Application, WO 9808840.
-
Duggan M.E. Hartman G.D. Hoffman W.F. Meissner R.S. Perkins J.J. Askew B.C. Coleman P.J. Hutchinson J.H. Naylor-Olsen A.M. ( 1998) Integrin Antagonists. International Patent Application, WO 9808840.
-
(1998)
Integrin Antagonists.
-
-
Duggan, M.E.1
Hartman, G.D.2
Hoffman, W.F.3
Meissner, R.S.4
Perkins, J.J.5
Askew, B.C.6
Coleman, P.J.7
Hutchinson, J.H.8
Naylor-Olsen, A.M.9
-
30
-
-
0034609772
-
3 antagonist
-
3 antagonist. J Med Chem 43 : 3736 3745.
-
(2000)
J Med Chem
, vol.43
, pp. 3736-3745
-
-
Duggan, M.E.1
Duong, L.T.2
Fisher, J.F.3
Hamill, T.G.4
Hoffman, W.F.5
Huff, J.R.6
Ihle, N.C.7
Leu, C.-T.8
Nagy, R.M.9
Perkins, J.J.10
Rodan, S.B.11
Wesolowski, G.12
Whitman, D.B.13
Zartman, A.E.14
Rodan, G.A.15
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