Effects of bafilomycin A1, a vacuolar type H+ ATPase inhibitor, on the thermosensitivity of a human pancreatic cancer cell line

International Journal of Hyperthermia

Volumn 22, Issue 4, 2006, Pages 275-285

  Hayashi, Yasuo ^a   Katayama, Kanji ^a   Togawa, Tamotsu ^a   Kimura, Toshihisa ^a   Yamaguchi, Akio ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Hyperthermia; Intra cellular pH; Pancreatic cancer cell; Thermosensitivity; Vacuolar type H+ ATPase inhibitor

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; ADENOSINE TRIPHOSPHATASE INHIBITOR; BAFILOMYCIN A1; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE TRANSPORT; CELL PH; CELL SECRETION; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; ENDOSOME; GROWTH INHIBITION; HEAT SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PROTON TRANSPORT; TREATMENT OUTCOME; TUMOR GROWTH;

AMILORIDE; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY TEMPERATURE REGULATION; CELL LINE, TUMOR; CELL MEMBRANE; COMBINED MODALITY THERAPY; ENZYME INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTHERMIA, INDUCED; MACROLIDES; MALE; MICE; MICE, NUDE; PANCREATIC NEOPLASMS; PROTON-TRANSLOCATING ATPASES; SODIUM-HYDROGEN ANTIPORTER; TRANSPLANTATION, HETEROLOGOUS;

EID: 33745077383     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730600708049     Document Type: Article

References (20)

1. Wike, JL and Hooley, W and Haveman, J and Reinhold, HS. (1984) The relevamce of tumour pH to the treatment of malignant disease Radiothera Oncol, 2, pp. 343-366.
2. Song, CW. (1984) Effect of local hyperthermia on blood flow and micro-environment: A review Cancer Res, 44, pp. 4721s-4730s.
3. Song, CW and Lyons, JC and Luo, Y. (1993) Intra- and extracellular pH in solid tumor: Influence of therapeutic response Mech Drug Resist Oncol, pp. 25-52. Marcel Dekker, New York
4. Lyons, JC and Kim, GE and Song, CW. (1992) Modification of intracellular pH and thermosensitivity Radiat Res, 29, pp. 79-87.
5. Song, CW and Lyons, JC and Griffin, RJ and Makepeace, CM and Cragoe, EJ, Jr. (1993) Increase in thermosensitivity of tumor cells by lowering intracellular pH Cancer Res, 53, pp. 1599-1601.
6. Yoshimori, T and Yamamoto, A and Moriyama, Y and Futai, M and Tashiro, Y. (1991) Bafilomycin A1, a specific inhibitor of vacular-type H+-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells J Biol Chem, 266, pp. 17707-17712.
7. Ohta, T and Nakagawara, H and Arakawa, H and Futagami, F and Tsukioka, Y and Kitagawa, H and Kyagaua, M and Nagakawa, T and Miyazaki, I. (1996) A new strategy for the therapy of pancreatic cancer invasion and metastasis by protease inhibitor and proton pump inhibitor agents Jpn J Gastroenterol Surg, 29, pp. 888-892.
8. Ohta, T and Numura, M and Yagishita, H and Futagami, F and Tsukioka, Y and Kitagawa, H and Kayahara, M and Nagakawa, T and Miyazaki, I and Yamamoto, M and (1996) Expression of 16 kilodalton proteolipid of vacuolar type H+ATPase in human pancreatic cancer Br J Cancer, 73, pp. 1511-1517.
9. Kim, GE and Lyons, JC and Song, CW. (1991) Effects of amiloride on intracellular pH and thermosensitivity Int J Radiat Oncol Biol Phys, 20, pp. 541-549.
10. Thomas, JA and Buchsbaum, RN and Zimniak, A and Racker, E. (1979) Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ Biochemistry, 18, pp. 2210-2219.
11. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays J Immunol Meth, 65, pp. 55-63.
12. Charmichael, J and Degraff, WG and Gadzar, AF and Minna, JD and Mitchell, JB. (1987) Evaluation of tetrazolium-based semi-automated colorimetric assay: Assessment of chemosensitivity testing Cancer Res, 47, pp. 936-941.
13. Song, CW and Lyons, JC and Griffin, RJ and Makepeace, CM. (1993) Thermosensitization by lowering intracellular pH with 5-(N-ethyl-N-isopropyl) amiloride Radiother Oncol, 27, pp. 252-258.
14. Song, CW and Lyons, JC and Makepeace, CM and Griffin, RJ and Cragoe, EJ, Jr. (1994) Effects of HMA, an analogs of amiloride, on the thermosensiivity of tumors in vivo Int J Radiat Oncol Biol Phys, 30, pp. 133-139.
15. Asaumi, J and Kawasaki, S and Nishikawa, K and Kuroda, M and Hiraki, Y. (1994) Effects of amiloride derivatives on the thermosensitivity of an adriamycin-resistant strain of Ehrlich ascites tumor cells Anticancer Res, 14, pp. 805-808.
16. Ohta, T and Arakawa, H and Futagawa, F and Fushida, S and Kitagawa, H and Kayahara, M and Nagakawa, T and Miwa, K and Kurashima, K and Numata, M and Kitamura, Y and Terada, T and Ohkuma, S. (1998) Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line capan-1 J Pathol, 85, pp. 324-330.
17. Song, CW and Park, HJ and Ross, MD. (1999) Intra- and extracellular pH in solid tumor Antiangiogenic Agents Cancer Ther (Cancer Drug Disc Dev), pp. 51-64. Humana Press, Totowa, NJ
18. Rhee, JG and Kim, TH and Levitt, SH and Song, CW. (1984) Changes in acidity of mouse tumor by hyperthermia Int J Radiat Oncol Biol Phys, 10, pp. 393-399.
19. Jayasundar, R and Honess, D and Hall, LD and Bleehen, NM. (2000) Simultaneous evaluation of the effects of RF hyperthermia on the intra- and extracellular tumor pH Magn Reson Med, 43, pp. 1-8.
20. Arakawa, H. (1999) Inhibitory effect of bafilomycin A1 on growth of human pancreatic ductal cancer cell lines Juzen Med Soc, 108, pp. 419-428.