Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q

Journal of Clinical Pathology

Volumn 59, Issue 6, 2006, Pages 624-630

  Al Mulla, F ^a   AlFadhli, S ^a   Al Hakim, A H ^a   Going, J J ^b   Bitar, M S ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME 14Q; CHROMOSOME 4; CHROMOSOME MICRODISSECTION; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HETEROZYGOSITY LOSS; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS;

AGED; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 4; COLORECTAL NEOPLASMS; DNA, NEOPLASM; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICRODISSECTION; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS;

EID: 33745076490     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2005.033167     Document Type: Article

References (26)

1. Kahlenberg MS, Sullivan JM, Witmer DD, et al. Molecular prognostics in colorectal cancer. Surg Oncol 2003;12:173-86.
2. Compton CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 2003;16:376-88.
3. Ovaska J, Jarvinen H, Kujari H, et al. Follow-up of patients operated on for colorectal carcinoma. Am J Surg 1990;159:593-6.
4. Olson RM, Perencevich NP, Malcolm AW, et al. Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum. Cancer 1980;45:2969-74.
5. Petersen VC, Baxter KJ, Love SB, et al. Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer. Gut 2002;51:65-9.
6. Hartsough MT, Steeg PS. Nm23-H1: genetic alterations and expression patterns in tumor metastasis. Am J Hum Genetics 1998;63:6-10.
7. Lombordi DP, Geradts J, Foley JF, et al. Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res 1999;59:5724-31.
8. Mulder JW, Wielenga VJ, Pals ST, et al. p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis. Histochem J 1997;29:439-52.
9. Muller O. Identification of colon cancer patients by molecular diagnosis. Dig Dis 2003;21:315-9.
10. Wein A, Hahn EG, Merkel S, et al. Adjuvant chemotherapy for stage II (Dukes' B) colon cancer: too early for routine use. Eur J Surg Oncol 2000;26:730-2.
11. Wolmark N, Rockette H, Mamounas E, et al. Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 1999;17:3553-9.
12. Kuo TH, Kubota T, Watanabe M, et al. Liver colonization competence governs colon cancer metastasis. Proc Natl Acad Sci USA 1995;92:12085-9.
13. Ramaswamy S, Ross KN, Lander ES, et al. A molecular signature of metastasis in primary solid tumors. Nat Genetics 2003;33:49-54.
14. Bertucci F, Salas S, Eysteries S, et al. Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogens 2004;23:1377-91.
15. Wang Y, Jatkoe T, Zhang Y, et al. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol 2004;22:1564-71.
16. Al-Mullo F, Behbehani Al, Bitar MS, et al. Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse. Mod Pathol. Published Online First: 10 March 2006. doi: 10.1038/modpathol.3800564.
17. Arribas R, Ribas M, Risques RA, et al. Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival. Clin Cancer Res 1999;5:3454-9.
18. Shivapurkar N, Maitra A, Milchgrub S, et al. Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma. Hum Pathol 2001;32:169-77.
19. Ookawa K, Sakamoto M, Hirohashi S, et al. Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int J Cancer 1993;53:382-7.
20. Sasaki M, Okamoto M, Sato C, et al. Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma. Cancer Res 1989;49:4402-6.
21. Young J, Leggett B, Ward M, et al. Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. Oncogene 1993;8:671-5.
22. Bando T, Kato Y, Ihara Y, et al. Loss of heterozygosity of 14q32 in colorectal carcinoma. Cancer Genetics Cytogenetics 1999;111:161-5.
23. Thorstensen L, Qvist H, Nesland JM, et al. Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas. Scand J Gastroenterol 2001;36:1327-31.
24. Al-Mulla F, Keith WN, Pickford IR, et al. Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases. Genes Chromosomes Cancer 1999;24:306-14.
25. Risques RA, Moreno V, Marcuello E, et al. Redefining the significance of aneuploidy in the prognostic assessment of colorectal cancer. Lab Invest 2001;81:307-15.
26. Diep CB, Kleivi K, Ribeiro FR, et al. The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes. Genes Chromosomes Cancer 2006;45:31-41.