The antipruritic effect of topical doxepin cream in patients with atopic dermatitis

Korean Journal of Dermatology

Volumn 44, Issue 3, 2006, Pages 309-314

  Lee, Hee Jung ^a   Park, Chang Ook ^a   Lee, Ju Hee ^a   Lee, Kwang Hoon ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Atopic dermatitis; Doxepin cream

Indexed keywords

DOXEPIN;

ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CREAM; DISEASE SEVERITY; DROWSINESS; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FACE EDEMA; HUMAN; PRURITUS; VISUAL ANALOG SCALE; XEROSIS; XEROSTOMIA;

EID: 33745049079     PISSN: 04944739     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Koblenzer CS. Itching and the atopic skin. J Allergy Clin Immunol 1999;104:S109-113
2. Schmelz M. A neuronal pathway for itch. Nat Neurosci 2001;4:8-10
3. Heyer G, Vogelsang M, Hornstein OP. Acetylcholine is an inducer of itching in patients with atopic dermatitis. J Dermatol 1997;24:621-625
4. Jarvikallio A, Naukkarinen A, Harvima IT, Aalto ML, Horsanheimo M. Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema. Br J Dermatol 1997;136:871-877
5. Gaspari AA, Lotze MT, Rosenberg SA, Stern JB, Katz SI. Dermatologic changes associated with interleukin 2 administration. JAMA 1987;258:1624-1629
6. Stander S, Steinhoff M. Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol 2002;11:12-24
7. Behrendt H, Ring J. Histamine, antihistamines and atopic eczema. Clin Exp Allergy 1990;20:25-30
8. Drake LA, Fallon JD, Sober A. Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group. J Am Acad Dermatol 1994;31:613-616
9. Hanifin JM, Cooper KD, Ho VC, Kang SW, Krafchik BR, Margolis DJ, et al. Guidelines of care for atopic dermatitis. J Am Acad Dermatol 2004;50:391-404
10. Gupta MA, Gupta AK, Ellis CN. Antidepressant drugs in dermatology. An update. Arch Dermatol 1987;123:647-652
11. Figueiredo A, Fontes Ribeiro CA, GonCalo M, Almeida L, Poiares-Baptista A, Teixeira F. Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol 1990;4:147-158
12. Bernstein JE, Whitney DH, Soltani K. Inhibition of histamine-induced pruritus by topical tricyclic antidepressants. J Am Acad Dermatol 1981;5:582-585
13. Drake LA, Millikan LE. The antipruritic effect of 5% doxepin cream in patients with eczematous dermatitis. Doxepin Study Group. Arch Dermatol 1995;131:1403-1408
14. Leung DYM, Eichenfield LF, Boguniewicz M. Atopic dermatitis, In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw-Hill, 2003:1180-1194
15. Sabroe RA, Kennedy CT, Archer CB. The effects of topical doxepin on responses to histamine, substance P and prostaglandin E2 in human skin. Br J Dermatol 1997;137: 386-390
16. Weidner C, Klede M, Rukwied R. Acute effects of substance P and calcitonin gene-related peptide in human skin-a microdialysis study. J Invest Dermatol 2000;115:1015-1020
17. Groene D, Martus P, Heyer G. Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema. Exp Dermatol 2001;10:110-117
18. Heyer GR, Hornstein OP. Recent studies of cutaneous nociception in atopic and non-atopic subject. J Dermatol 1999;26:77-86
19. Richelson E. Antimuscarinic and other receptor-blocking properties of antidepressants. Mayo Clin Proc 1983;58:40-46
20. Bonnel RA, La Grenade L, Karwoski CB, Beitz JG. Allergic contact dermatitis from topical doxepin; Food and Drug Administration's postmarketing surveillance experience. J Am Acad Dermatol 2003;48:294-296