Ortho-hydroxylation of phenol by tyrosinase model compounds

Chinese Chemical Letters

Volumn 16, Issue 2, 2005, Pages 147-150

  Yuan, Dai Rong ^a   Yan, Jia Ming ^a   Yu, Cheng Zhi ^a   Xie, Ru Gang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Binuclear copper (I) complex; Mimic enzyme catalysis; Ortho hydroxylation of phenol; Polyimidazole; Tyrosinase model compound

Indexed keywords

EID: 33745042451     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

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16. 2 (10/5 mL/mL). The reaction mixture was stirred at 0°C for 7 h by bubbling dioxygen directly into reaction vessel, and then was stirred at room temperature for additional 13 h. The initial faint yellow solution was present dark brown at the end of reaction. The mixture was diluted with 10 mL diethyl ether and 50 mL saturation sodium chloride solution. The aqueous layer was extracted with diethyl ether (2×10 mL) and the combined organic extracts were dried over anhydrous MgSO4. Removal of the solvent under reduced pressure afforded a residue that was purified through silica gel column (petrol ether/dichloromethane, 10/1).