In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D2 receptors

European Journal of Pharmacology

Volumn 540, Issue 1-3, 2006, Pages 53-56

  Jordan, Shaun ^a   Chen, Ruoyan ^a   Fernalld, Raymond ^a   Johnson, Janelle ^a   Regardie, Karen ^a   Kambayashi, Junichi ^a   Tadori, Yoshihiro ^b   Kitagawa, Hisashi ^b   Kikuchi, Tetsuro ^b  

^a OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antipsychotic; Confocal microscopy; Glutamate; Schizophrenia

Indexed keywords

CALCIUM; DIZOCILPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENCYCLIDINE; PSYCHEDELIC AGENT; RACLOPRIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASSAY; BIOCHEMISTRY; CALCIUM MOBILIZATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; IN VITRO STUDY; MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SCHIZOPHRENIA;

ANIMALS; BINDING, COMPETITIVE; CALCIUM; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DIZOCILPINE MALEATE; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; KETAMINE; PHENCYCLIDINE; RACLOPRIDE; RATS; RECEPTORS, DOPAMINE D2; SULFUR RADIOISOTOPES;

EID: 33745004116     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.04.026     Document Type: Article

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