A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability

European Journal of Medicinal Chemistry

Volumn 41, Issue 6, 2006, Pages 768-772

  Mucha, A ^a   Kunert, A ^a   Grembecka, J ^a   Pawelczak M ^b   Kafarski, P ^a,b  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF OPOLE   (Poland)

Author keywords

Hydrolytic stability; LAP inhibitors; Phosphonamidate

Indexed keywords

AMINOPEPTIDASE; CYTOSOL AMINOPEPTIDASE; DILITHIUM N [(2 AMINOPHENYL)OXYPHOSPHINYL]GLYCINATE; DIPEPTIDE DERIVATIVE; PHOSPHONAMIDATE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WATER; ZINC ION;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CORRELATION ANALYSIS; DRUG DESIGN; DRUG HYDROLYSIS; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ASSAY; PH;

DRUG DESIGN; DRUG STABILITY; LEUCYL AMINOPEPTIDASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEASE INHIBITORS;

EID: 33744995204     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.03.023     Document Type: Article

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