Lambda's Switch: Lessons from a Module Swap

Current Biology

Volumn 16, Issue 12, 2006, Pages

  Ptashne, Mark ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGE LAMBDA REPRESSOR PROTEIN; DNA BINDING PROTEIN; REPRESSOR PROTEIN; VIRUS PROTEIN;

BACTERIOPHAGE LAMBDA; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; OPERATOR GENE; PHYSIOLOGY; SHORT SURVEY;

BACTERIOPHAGE LAMBDA; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, VIRAL; MODELS, GENETIC; OPERATOR REGIONS (GENETICS); REPRESSOR PROTEINS; VIRAL PROTEINS;

EID: 33744984357     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.05.037     Document Type: Short Survey

References (14)

1. Atsumi S., and Little J.W. Role of the lytic repressor in prophage induction of phage lambda as analyzed by a module-replacement approach. Proc. Natl. Acad. Sci. 103 (2006) 4558-4563
2. Ptashne M. A Genetic Switch: Phage Lamba Revisited. Third edition (2004), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
3. Little J.W., Shepley D.P., and Wert D.W. Robustness of a gene regulatory circuit. EMBO J. 18 (1999) 4299-4307
4. Dodd I.B., Shearwin K.E., and Egan J.B. Revisited gene regulation in bacteriophage lambda. Curr. Opin. Genet. Dev. 15 (2005) 145-152
5. Dodd I.B., Perkins A.J., Tsemitsidis D., and Egan J.B. Octamerization of lambda CI repressor is needed for effective repression of PRM and efficient switching from lysogeny. Genes Dev. 15 (2001) 3013-3022
6. Dodd I.B., Shearwin K.E., Perkins A.J., Burr T., Hochschild A., and Egan J.B. Cooperativity in long-range gene regulation by the lambda CI repressor. Genes Dev. 18 (2004) 344-354
7. Bell C.E., Frescura P., Hochschild A., and Lewis M. Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding. Cell 101 (2000) 801-811
8. Bell C.E., and Lewis M. Crystal structure of the lambda repressor C-terminal domain octamer. J. Mol. Biol. 314 (2001) 1127-1136
9. Jain D., Nickels B.E., Sun L., Hochschild A., and Darst S.A. Structure of a ternary transcription activation complex. Mol. Cell 13 (2004) 45-53
10. Kobiler O., Rokney A., Friedman N., Court D.L., Stavans J., and Oppenheim A.B. Quantitative kinetic analysis of the bacteriophage lambda genetic network. Proc. Natl. Acad. Sci. USA 102 (2005) 4470-4475
11. Johnson A.D., Poteete A.R., Lauer G., Sauer R.T., Ackers G.K., and Ptashne M. Lambda repressor and cro-components of an efficient molecular switch. Nature 294 (1981) 217-223
12. Svenningsen S.L., Costantino N., Court D.L., and Adhya S. On the role of Cro in lambda prophage induction. Proc. Natl. Acad. Sci. USA 102 (2005) 4465-4469
13. Michalowski C.B., and Little J.W. Positive autoregulation of cI is a dispensable feature of the phage lambda gene regulatory circuitry. J. Bacteriol. 187 (2005) 6430-6442
14. Ptashne M., and Gann A. Imposing specificity by localization: mechanism and evolvability. Curr. Biol. 8 (1998) R812-R822