Probing the substrate specificity of four different sialyltransferases using synthetic β-d-Galp-(1 → 4)-β-d-GlcpNAc-(1 → 2)-α-d-Manp-(1 → O) (CH2)7CH3 analogues. General activating effect of replacing N-acetylglucosamine by N-propionylglucosamine

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 4, 2006, Pages 685-692

  Rohfritsch, Philippe F ^a   Joosten, John A F ^a   Krzewinski Recchi, Marie Ange ^b   Harduin Lepers, Anne ^b   Laporte, Benoit ^b   Juliant, Sylvie ^c   Cerutti, Martine ^c   Delannoy, Philippe ^b   Vliegenthart, Johannes F G ^a   Kamerling, Johannis P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

^c CNRS   (France)

Author keywords

Sialyltransferases; Substrate specificity; Synthetic analogue

Indexed keywords

GLUCOSAMINE DERIVATIVE; N ACETYLGLUCOSAMINE; SIALYLTRANSFERASE; DRUG DERIVATIVE; GLUCOSAMINE; N PROPANOYLGLUCOSAMINE; N-PROPANOYLGLUCOSAMINE; OLIGOSACCHARIDE;

ACETYLATION; AMINO ACID SUBSTITUTION; ANALYTIC METHOD; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME SPECIFICITY; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN STRUCTURE; REACTION ANALYSIS; SYNTHESIS; ANIMAL; CARBOHYDRATE ANALYSIS; CHEMISTRY; HUMAN; METABOLISM; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLGLUCOSAMINE; ANIMALS; CARBOHYDRATE SEQUENCE; GLUCOSAMINE; HUMANS; OLIGOSACCHARIDES; RATS; SIALYLTRANSFERASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33744978550     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2005.12.012     Document Type: Article

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