Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 7, 2006, Pages 1080-1087

  Qiu, Yongge ^a   Li, Ding ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cancer; Cardiovascular disease; Cholesterol; Fluorinated inhibitor; Mevalonate 5 diphosphate decarboxylase; Mevalonate kinase

Indexed keywords

2 FLUOROMEVALONATE 5 DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBOXYLYASE; ENZYME INHIBITOR; MEVALONATE 5 DIPHOSOPHATE DECARBOXYLASE; MEVALONATE KINASE; P' GERANYL 2 FLUOROMEVALONATE 5 DIPHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER; CARDIOVASCULAR DISEASE; CHOLESTEROL SYNTHESIS; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE; FLUORINATION; IC 50; MEDICAL INFORMATION; MOLECULAR CLONING; NONHUMAN; PEROXISOME; PEST CONTROL; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ANIMALS; CARBOXY-LYASES; CARDIOVASCULAR SYSTEM; CHOLESTEROL; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORINE; INHIBITORY CONCENTRATION 50; KINETICS; MEVALONIC ACID; MODELS, CHEMICAL; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RATS; SUBSTRATE SPECIFICITY;

EID: 33744972306     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2006.03.009     Document Type: Article

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