Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke

Hypertension

Volumn 47, Issue 6, 2006, Pages 1209-1215

  Willmot, Mark ^a   Ghadami, Andrew ^a   Whysall, Beverly ^a   Clarke, Wim ^a   Wardlaw, Joanna ^b   Bath, Philip M W ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cerebral arteries; Hypertension, arterial; Nitric oxide; Nitroglycerin; Stroke

Indexed keywords

ANTIHYPERTENSIVE AGENT; GLYCERYL TRINITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; DIAGNOSTIC AGENT; XENON;

AGED; ANALYSIS OF COVARIANCE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BRAIN ARTERY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PERFUSION; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; FALLING; FEMALE; HEMISPHERE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STROKE; SYSTOLIC BLOOD PRESSURE; BRAIN CIRCULATION; CEREBROVASCULAR ACCIDENT; DRUG EFFECT; MIDDLE AGED; PATHOPHYSIOLOGY; RADIOGRAPHY;

AGED; AGED, 80 AND OVER; BLOOD PRESSURE; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NITRIC OXIDE DONORS; NITROGLYCERIN; TOMOGRAPHY, X-RAY COMPUTED; XENON;

EID: 33744970068     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000223024.02939.1e     Document Type: Article

References (28)

1. Leonardi-Bee J, Bath PMW, Phillips SJ. Sandercock PAG, for the IST Collaborative Group. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke. 2002;33:1315-1320.
2. Willmot M, Leonardi-Bee J, Bath PM. High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension. 2004;43:18-24.
3. Dandapani BK, Suzuki S, Kelley RE, Reyes-Iglesias Y, Duncan R. Relation between blood pressure and outcome in intracerebral haemorrhage. Stroke. 1995;26:21-24.
4. Lisk DR, Grotta JC, Lamki LM, Tran HD, Taylor JW, Molony DA, Barron BJ. Should hypertension be treated after acute stroke? A randomized controlled trial using single photon emission computed tomography. Arch Neurol. 1993;50:855-862.
5. Vorstrup S, Andersen GS, Blegvad N, Paulson OO. Calcium antagonist (PY 108-068) treatment may further decrease flow in ischaemic areas in acute stroke. J Cereb Blood Flow Metab. 1986;6:222-229.
6. Waldemar G, Vorstrup S, Andersen AR, Pedersen H, Paulson OB. Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. J Cardiovasc Pharmacol. 1989;14:722-729.
7. Dyker AG, Grosset DG, Lees K. Perindopril reduces blood pressure but not cerebral blood flow in patients with recent cerebral ischemic stroke. Stroke. 1997;28:580-583.
8. Nazir FS, Overell JR, Bolster A, Hilditch TE, Reid JL, Lees KR. The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke. J Hypertens. 2004;22:989-995.
9. Hancock SM, Eastwood JR, Mahajan RP. Effects of inhaled nitrous oxide 50% on estimated cerebral perfusion pressure and zero flow pressure in healthy volunteers. Anaesthesia. 2005;60:129-132.
10. Bath PMW, Pathansali R, Iddenden R, Bath FJ. The effect of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure and platelet function in acute stroke. Cerebrovasc Dis. 2001;11:265-272.
11. Rashid P, Weaver C, Leonardi-Bee JA, Fletcher S, Bath FJ, Bath PMW. The effects of transdermal glyceryl trinitrate, a nitric oxide donor on blood pressure, cerebral and cardiac haemodynamics and plasma nitric oxide levels in acute stroke. J Stroke Cerebrovasc Dis. 2003;13:143-151.
12. Chi OZ, Wei HM, Weiss HR. Effects of CAS 754, a new nitric oxide donor, on regional cerebral blood flow in focal cerebral ischemia. Anesthesia Analgesia. 1995;80:703-708.
13. Salom JB, Orti M, Centeno JM, Torregrosa G, Alborch E. Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats. Brain Res. 2000;865:149-156.
14. Willmot MR, Bath PMW. The potential of nitric oxide therapeutics in stroke. Exp Opin Investig Drugs. 2003;12:455-470.
15. Butterworth RJ, Cluckie A, Jackson SHD, Buxton-Thomas M, Bath PMW. Pathophysiological assessment of nitric oxide (given as sodium nitroprusside) in acute ischaemic stroke. Cerebrovasc Dis. 1998;8:158-165.
16. Yonas H, Pindzola RP, Johnson DW. Xenon/computed tomography cerebral blood flow and its use in clinical management. Neurosurg Clin N Am. 1996;7:605-616.
17. Siesjo BK. Pathophysiology and treatment of focal cerebral ischaemia Part 1: pathophysiology. J Neurosurg. 1992;77:169-184.
18. Baron J. Perfusion thresholds in human cerebral ischemia: historical perspective and therapeutic implications. Cerebrovasc Dis. 2004;11:2-8.
19. Hossmann K. Viability thresholds and the penumbra of focal ischemia. Ann Neurol. 1994;36:557-565.
20. Touho H, Karasawa J. Evaluation of time-dependent thresholds of cerebral blood flow and transit time during the acute stage of cerebral embolism: a restrospective study. Surg Neurol. 1996;46:135-136.
21. Hennerici M, Rautenberg W, Sitzer G, Schwartz A. Transcranial doppler for the assessment of intracranial arterial flow velocity - Part 1. Surg Neurol. 1987;27:439-448.
22. O'Brien E, Mee F, Atkins N, Thomas M. Evaluation of three devices for self-measurement of blood pressure according to the revised British Hypertension Society Protocol: the Omron HEM-705CP, Philips HP5332, and Nissei DS-175. Blood Press Monit. 1996;1:55-61.
23. Athanassiou L, Hancock SM, Mahajan RP. Doppler estimation of zero flow pressure during changes in downstream pressure in a bench model of a circulation using pulsatile flow. Anaesthesia. 2005;60:133-138.
24. Optimising Analysis of Stroke Trials (OAST) Collaborators, Bath PMW. Optimising the statistical analysis of functional outcome in stroke trials. Stroke. 2003;34:316. Abstract.
25. Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke. 1994;25:429-435.
26. Morikawa E, Rosenblatt S, Moskowitz MA. L-arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. Br J Pharmacol. 1992;107:905-907.
27. Rashid PA, Whitehurst A, Lawson N, Bath PMW. Plasma nitric oxide (nitrate/nitrite) levels in acute stroke and their relationship with severity and outcome. J Stroke Cerebrovasc Dis. 2003;12:82-87.
28. Bath PM. Major ongoing stroke trials: Efficacy of Nitric Oxide in Stroke (ENOS) trial. Stroke. 2001;32:2450-2451. Abstract.