Emergence and takeover of precore-stop mutant prior to exacerbation of E antigen-negative chronic hepatitis B after withdrawal of lamivudine therapy

Journal of Medical Virology

Volumn 78, Issue 7, 2006, Pages 906-910

  Yeh, Chau Ting ^a,b   Lin, Wei Pin ^a   Hsu, Chao Wei ^a   Chang, Ming Ling ^a   Lin, Shi Ming ^a   Sheen, I Shyan ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Amplification created restriction site; Nonsense mutation; Ratio

Indexed keywords

AMINOTRANSFERASE; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; VIRUS DNA;

ADULT; AMINOTRANSFERASE BLOOD LEVEL; AMPLIFICATION CREATED RESTRICTION SITE METHOD; ARTICLE; CASE REPORT; CODON; DISEASE EXACERBATION; DRUG WITHDRAWAL; FEMALE; GENE AMPLIFICATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER NECROSIS; MALE; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; RESTRICTION MAPPING; STOP CODON; VIRUS MUTANT; VIRUS TITRATION;

ADULT; ANTIVIRAL AGENTS; BASE SEQUENCE; CODON, NONSENSE; DNA, VIRAL; FEMALE; GENES, VIRAL; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LAMIVUDINE; MALE; MIDDLE AGED; PROMOTER REGIONS (GENETICS);

HEPATITIS B VIRUS;

EID: 33744961275     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.20639     Document Type: Article

References (28)

1. Bonino F, Brunetto MR. 2003. Chronic hepatitis B e antigen (HBeAg) negative, anti-HBe positive hepatitis B: An overview. J Hepatol 39: S160-S163.
2. Brunetto MR, Stemler M, Bonino F, Schodel F, Oliveri F, Rizzetto M, Verme G, Will H. 1990. A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol 10:258-261.
3. Bruss V, Gerlich WH. 1988. Formation of transmembraneous hepatitis B e-antigen by cotranslational in vitro processing of the viral precore protein. Virology 163:268-275.
4. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A. 1989. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2:588-591.
5. Chu CM, Yeh CT, Lee CS, Sheen IS, Liaw YF. 2002. Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: Clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion. J Clin Microbiol 40:16-21.
6. Fattovich G. 2003. Natural history of hepatitis B. J Hepatol 39:S50-S58.
7. Ganem D, Varmus HE. 1987. The molecular biology of the hepatitis B viruses. Annu Rev Biochem 56:651-693.
8. Garcia PD, Ou JH, Rutter WJ, Walter P. 1988. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: After signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol 106:1093-1104.
9. Hadziyannis SJ, Papatheodoridis GV, Vassilopoulos D. 2003. Treatment of HBeAg-negative chronic hepatitis B. Semin Liver Dis 23:81-88.
10. Hoofnagle JH. 1983. Chronic type B hepatitis. Gastroenterology 84:422-424.
11. Jean-Jean O, Levrero M, Will H, Perricaudet M, Rossignol JM. 1989. Expression mechanism of the hepatitis B virus (HBV) C gene and biosynthesis of HBe antigen. Virology 170:99-106.
12. Kao JH, Chen PJ, Lai MY, Chen DS. 2000. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 11:554-559.
13. Li JS, Tong SP, Wen YM, Vitvitski L, Zhang Q, Trepo C. 1993. Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: Possible contribution of a single nucleotide in the precore region. J Virol 67:5402-5410.
14. Marinos G, Torre F, Chokshi S, Hussain M, Clarke BE, Rowlands DJ, Eddleston AL, Naoumov NV, Williams R. 1995. Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: A major factor in activation of the host immune response to the hepatitis B virus. Hepatology 22:1040-1049.
15. Moriyama K, Okamoto H, Tsuda F, Mayumi M. 1996. Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections. Virology 226:269-280.
16. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M. 1990. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64:1298-1303.
17. Oketani M, Oketani K, Xiaohong C, Arima T. 1999. Low level wild-type and pre-core mutant hepatitis B viruses and HBeAg negative reactivation of chronic hepatitis B. J Med Virol 58:332-337.
18. Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. 1991. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 324:1699-1704.
19. Ou JH, Laub O, Rutter WJ. 1986. Hepatitis B virus gene function: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci USA 83:1578-1582.
20. Parekh S, Zoulim F, Ahn SH, Tsai A, Li J, Kawai S, Khan N, Trepo C, Wands J, Tong S. 2003. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 77:6601-6612.
21. Perrillo RP. 2005. Current treatment of chronic hepatitis B: Benefits and limitations. Semin Liver Dis 25:20-28.
22. Scaglioni PP, Melegari M, Wands JR. 1996. Recent advances in the molecular biology of hepatitis B virus. Baillieres Clin Gastroenterol 10:207-225.
23. Standring DN, Ou JH, Masiarz FR, Rutter WJ. 1988. A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc Natl Acad Sci USA 85:8405-8409.
24. Thomas HC, Carman WF. 1992. The host immune response may be responsible for selection of envelope and precore/core variants of HBV. Prog Liver Dis 10:239-251.
25. Tong SP, Li JS, Vitvitski L, Trepo C. 1992. Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: Relevance of pregenome encapsidation signal. Virology 191:237-245.
26. Yeh CT, Chu CM, Liaw YF. 1998. Progression of the proportion of hepatitis B virus precore stop mutant following acute superinfection of hepatitis C. J Gastroenterol Hepatol 13:131-136.
27. Yeh CT, Sheen IS, Chen TC, Hsieh SY, Chu CM, Liaw YF. 2000. Prednisolone modulates the therapeutic effect of interferon to eliminate preferentially the hepatitis B virus precore stop mutant. J Hepatol 32:829-836.
28. Yeh CT, Chang MH, Lai HY, Chang ML, Chu CM, Liaw YF. 2003. Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen. J Gastroenterol Hepatol 18:1129-1138.