Diagnosis and management of laryngopharyngeal reflux disease

Current Opinion in Otolaryngology and Head and Neck Surgery

Volumn 14, Issue 3, 2006, Pages 124-127

  Divi, Venu ^a   Benninger, Michael S ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Laryngopharyngeal reflux; Proton pump inhibitor; Reflux disease

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST; METOCLOPRAMIDE; PROKINETIC AGENT; PROTON PUMP INHIBITOR;

ABSENCE OF SIDE EFFECTS; BARRETT ESOPHAGUS; BEHAVIOR MODIFICATION; BLOATING; CLINICAL FEATURE; CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE; COMPARATIVE STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST; DISEASE SEVERITY; DRUG DOSE REGIMEN; DRUG SAFETY; GASTROESOPHAGEAL REFLUX; HUMAN; INFECTION RISK; LARYNGOPHARYNGEAL REFLUX; PHYSICAL EXAMINATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RELIABILITY; REVIEW; SCREENING TEST; SINGLE DRUG DOSE; STOMACH DISEASE; TREATMENT INDICATION;

GASTROESOPHAGEAL REFLUX; HUMANS; HYPOPHARYNX;

EID: 33744956009     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.moo.0000193200.78214.e9     Document Type: Review

References (13)

1. Hanson DG, Jiang J, Chi W. Quantitative color analysis of laryngeal erythema in chronic posterior laryngitis. J Voice 1998; 12:78-83.
2. Qadeer MA, Swoger J, Milstein C, et al. Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux. Laryngoscope 2005; 115:1947-1952. This article demonstrates that improvement in LPR symptoms does not correlate to an improvement in signs of LPR.
3. Hicks DM, Ours TM, Abelson TI, et al. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice 2002; 16:564-579. A reasonable evaluation of the prevalence of LPR signs in the normal population.
4. Hill KR, Simpson BC, Velazquez R, Larson N. Pachydermia is not diagnostic of active laryngopharyngeal reflux disease. Laryngoscope 2004; 114:1557-1561. This paper found no difference in the prevalence of pachydermia in normal patients and those being treated with reflux.
5. Halum S, Postma GN, Johnston C, et al. Patients with isolated laryngopharyngeal reflux are not obese. Laryngoscope 2005; 115:1042-1045. GER disease is associated with increasing body mass index, but LPR has no correlation with the patient's weight.
6. Park W, Hicks D, Khandwala F, et al. Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors response. Laryngoscope 2005; 115:1230-1238. Twice-daily PPI therapy was found to be superior to daily therapy, although nighttime addition of H2 blockers added no benefit.
7. Dial S, Delaney JAC, Barkun AN, Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA 2005; 294:2989-2995. Although no examination was made regarding the duration of therapy, the researchers were able to demonstrate increased risk of C. difficile infection when using H2 blockers or PPIs.
8. Merati AL, Lim HJ, Ulualp SO, Toohil PJ. Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 2005; 114:177-182.
9. Wong WM, Bautista R, Dekel IB, et al. Feasibility and tolerability of transnasal/per-oral placement of the wireless pH capsule vs. traditional 24 h esophageal pH monitoring. Aliment Pharmacol Ther 2005; 21:155-163.
10. Belafsky P, Godin D, Garcia JC, Rahim N. Comparison of data obtained from sedated versus unsedated wireless telemetry capsule placement. Laryngoscope 2005; 115:1109-1113.
11. Reavis K, Morris C, Gopal D, et al. Laryngopharyngeal reflux symptoms better predict the presence of esophageal adenocarcinoma than typical gastroesophageal reflux symptoms. Ann of Surg 2004; 239:849-858. The results of this review demonstrate increased correlation of Barrett's esophagus with LPR, but no screening recommendations were made.
12. Poelmans J, Feenstra I, Demedts P, et al. The yield of upper gastrointestinal endoscopy in patients with suspected reflux related chronic ear, nose, and throat symptoms. Am J Gastroenterol 2004; 99:1419-1426.
13. Ford C. Evaluation and management of laryngopharyngeal reflux. JAMA 2005; 294:1534-1540. An excellent review of the approach to evaluating and treating the patient with LPR with a well developed algorithm. Good discussion of current controversies in the treatment of reflux.