Effects of Long-term Ingestion of Jelly Drink Containing Garcinia cambogia Extract and Partially Hydrolized Guar Gum on Obesity

Journal of Oleo Science

Volumn 53, Issue 4, 2004, Pages 197-205

  Anno, Takahiko ^a   Oono, Hiromi ^a   Tomi, Hironori ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

Garcinia; hydroxycitric acid; obesity; visceral fat

Indexed keywords

EID: 33744952426     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.53.197     Document Type: Article

References (24)

1. Y.S. LEWIS and S. NEELAKANTAN, (—)-Hydroxycitric Acid the Principal Acid in the Fruits of Garcinia cambogia Desr, Phytochemistry, Vol. 4, 619-625 (1965).
2. J.A. WATSON and J.M. LOWENSTEIN, Citrate and the Conversion of Carbohydrate into Fat. Fatty Acid Synthesis by a Combination of Cytoplasm and Mitochondria, J. Biol. Chem., Vol. 245, 5993-6002 (1970).
3. J.A. WATSON, M. FANG and J.M. LOWENSTEIN, Tricarballylate and Hydroxycitrate: Substrate and Inhibitor of ATP: Citrate Oxaloacetate Lyase, Arch. Biochem. Biophys., Vol. 135, 209-217 (1969).
4. A.C. SULLIVAN, M. SINGH, PA. SRERE and J.P. GLUSKER, Reactivity and Inhibitor Potential of Hydroxycitrate Isomers with Citrate Synthase, Citrate Lyase, and ATP Citrate Lyase, J. Biol. Chem., Vol. 252, 7583-7590 (1977).
5. A.C. SULLIVAN, J. TRISCARI, J.G. HAMILTON, O.N. MILLER and VR. WHEATLEY, Effect of (—)-Hydroxycitrate upon the Accumulation of Lipid in the Rat: II. Appetite, Lipids, Vol. 9, 129-134 (1974).
6. A. A. CONTE, A Non-Prescription Alternative in Weight Reduction Therapy, The Bariatrician-Summer, 17-19 (1993).
7. W. SERGIO, A Natural Food, the Malabar Tamarind, may be Effective in the Treatment of Obesity, Medical Hypotheses, Vol. 27, 39-40 (1988).
8. R.R. RAMOS, J.L.F. SAENZ and F.J.A. AGUILAR, Extract de Garcinia cambogia en el Control de la Obesidad, Med. Internat., Vol. 22, 97-100 (1995).
9. S.B. HEYMSFIELD, D.B. ALLISON, J.R. VASSELLI, A. PIETROBELLI, D. GREENFIELD and C. NUNETZ, Garcinia cambogia (Hydroxyditric Acid) as a Potential Antiobesity Agent A Randomized Controlled Trial, JAMA, Vol. 280, 1596-1600 (1998).
10. K. ONOMURA, H. TOMI, R. OTSUKA and K. KAWABATA, Effects of Chronic Ingestion of Jelly Drink Containing Garcinia Extract on Body Fat Mass, J. Nutr. Foods, Vol. 3, 23-30 (2000).
11. K. HAYAMIZU, Y. Ishii, I. KANEKO, M. SHEN, H. SAKAGUCHI, Y. OKUHARA, N. SHIGEMATSU and H. SHIMASAKI, No-Observed-Adverse-Effect Level (NOAEL) and Sequential-High-Dose Administration Study on Garcinia cambogia Extract in Humans, J. Oleo Sci., Vol. 51, 365-369 (2002).
12. H. SAWADA, H. TOMI, K. TAMURA and T. ANNO, Effects of Liquid Garcinia Extract and Soluble Garcinia Powder on Body Weight Change —A Possible Material for Suppressing Fat Accumulation —, J. Jpn Oil Chem. Soc., Vol. 46, 1467-1474 (1997).
13. K. HAYAMIZU, Y. Ishii, I. KANEKO, M. SHEN, H. SAKAGUCHI, Y. OKUHARA, N. SHIGEMATSU, S. MIYAZAKI and H. SHIMASAKI, Effects of Long-term Administration of Garcinia cambogia Extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial, J. Oleo Sci., Vol. 50, 805-812 (2001).
14. K. HAYAMIZU, Y. Ishii, N. SHIGEMATSU, Y. OKUHARA, H. TOMI, M. FURUSE, G. YOSHINO and H. SHIMASAKI, Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I, J. Oleo Sci., Vol. 52, 499-503 (2003).
15. H. TAKAHASHI and M. KIM, New Functions of Water-soluble Dietary Fibers. Some Physiological Effects such as Enhancement Action of Mineral Absorption in Enzymatic Decomposition of Guar Gum, Kagaku to Seibutsu, Vol. 33, 287-289, (1995).
16. H. HARA, T. SUZUKI, T. KASAI, Y. AOYAMA and A. OHTA, Ingestion of Guar Gum Hydrolysate, a Soluble Fiber, increases Calcium Absorption in Totally Gastrectomized Rats, J. Nutr., Vol. 129, 39-45 (1999).
17. T. ANNO, H. OONO, H. TOMI, K. KISHIDA, S. ISHIBASHI and K. IWAKURA, A 26-week Repeated Dietary Dose Toxicity Study of Free-type or Ca-type Garcinia Extract in Rats, Jpn. J. Food Chem., Vol. 10, 85-95 (2003).
18. K. SEKITA, Y. OGAWA, S. KITAJIMA, Y. SAITO, T. NAGATA, T. INOUE and J. KANNO, Toxicity Study of Garcinia cambogia Extract II: A 28-day Dietary Exposure of Hydroxycitric Acid, a Principal Ingredient of Garcinia cambogia Extract, on Testicular Toxicity in Rats, The 30 th Annual Meeting of the Japanese Society of Toxicology 189 11 (2003).
19. S.A. HILD, J.R. REEL, J.M. LARNER and R.P. BLYE, Disruption of Spermatogenesis and Sertoli Cell Structure and Function by the Indenopyridine CDB-4022 in Rats, Biology of Reproduction, Vol. 65, 1771-1779 (2001).
20. B.D. ANAWALT, R.A. BEBB, A.M. MATSUMOTO, N.P. GROOME, P.J. ILLNGWORTH, A.S. McNEILLY and W.J. BREMNER, Serum Inhibin B Levels Reflect Sertori Cell Function in Normal Men and Men with Testicular Dysfunction, J. Clin. Endocrinol Metab., Vol. 81, 3341-3345 (1996).
21. T.K. JENSEN, A.M. ANDERRSSON, N.H. HJOLLUND, T. SCHEIKE, H. KOLSTAD, A. GIWERCMAN, T.B. HENRIKSEN, E. ERNST, J.P. BONDE, J. OLSEN, A. McNEILLY, N.P. GROOME and N.E. SKAKKEBAEK, Inhibin B as a Serum Maker of Spermatogenesis: Correlation to Differences in Sperm Concentration and Follicle-Stimulating Hormone Levels, A Study of 349 Danish Men, J. Clin. Endocrinol Metab., Vol. 82, 4059-4063 (1997).
22. F.H. PIERIK, J.T. VREEBURG, T. STIJNEN, F.H. De JONG and R.F. WEBER, Serum Inhibin B as a Maker of Spermatogenesis, J. Clin. Endocrinol Metab., Vol. 83, 3110-3114 (1998).
23. T.K. MOSEES, M. FRANZ, S. GEBHARDT, U. WINTER-STEIN, W.B. SCHILL and J. HAYATPOUR, Sertoli Cells as a Ta rget for Reproductive Hazards, Andrologia, Vol. 32, 239-246 (2000).
24. Y. Ishii, I. KANEKO, M. SHEN, K. HAYAMIZU, N. SHIGEMATSU, H. TOMI, G. YOSHINO and H. SHIMASAKI, Safety of Garcinia cambogia Extract in Healthy Volunteers: High-Doses Administration Study II, J. Oleo Sci., Vol. 52, 663-671 (2003).