Prevention and reversal of vasospasm and ultrastructural changes in basilar artery by continuous infusion of CGS 35066 following subarachnoid hemorrhage

Experimental Biology and Medicine

Volumn 231, Issue 6, 2006, Pages 1069-1074

  Kwan, Aij Lie ^a,b   Lin, Chih Lung ^a   Yen, Chun Po ^a   Winardi, William ^a   Su, Yu Feng ^a   Winardi, Daniel ^a   Dai, Zen Kong ^a   Jeng, Arco Y ^c   Kassell, Neal F ^b   Howng, Sheng Long ^a   Wang, Chih Jen ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b UNIVERSITY OF VIRGINIA   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Cerebral vasospasm; CGS 35066; Electron microscopy; Endothelin converting enzyme; Subarachnoid hemorrhage

Indexed keywords

CGS 35066; ENDOTHELIN CONVERTING ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; BASILAR ARTERY; BRAIN VASOSPASM; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; NONHUMAN; RABBIT; SUBARACHNOID HEMORRHAGE;

ANIMALS; BASILAR ARTERY; BENZOFURANS; INFUSIONS, INTRAVENOUS; MALE; PHOSPHONIC ACIDS; PROTEASE INHIBITORS; RABBITS; SUBARACHNOID HEMORRHAGE; VASOSPASM, INTRACRANIAL;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33744941828     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (14)

1. Kassell NF, Sasaki T, Colohan ART, Nazar G. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16:562-572, 1985.
2. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415, 1988.
3. Kwan AL, Bavbek M, Jeng AY, Maniara W, Toyoda T, Lappe RW, Kassell NF, Lee KS. Prevention and reversal of cerebral vasospasm by an endothelin- converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage. J Neurosurg 87:281-286, 1997.
4. Kwan AL, Lin CL, Chang CZ, Winardi D, Yen CP, Kassell NF, Hwong SL, Jeng AY, Lee KS. Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage. Neurosurgery 49:422-429, 2001.
5. Caner HH, Kwan AL, Arthur A, Jeng AY, Lappe RW, Kassell NF, Lee KS. Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage. J Neurosurg 85:917-922, 1996.
6. De Lombaert S, Ghai RD, Jeng AY, Trapani AJ, Webb RL. Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme. Biochem Biophys Res Commun 204:407-412, 1994.
7. Trapani AJ, Beil ME, Bruseo CW, De Lombaert S, Jeng AY. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J Cardiovasc Pharmacol 36(Suppl 1):S40-S43, 2000.
8. Kwan AL, Bavbek M, Jeng AY, Maniara W, Toyoda T, Lappe RW, Kassell NF, Lee KS. Prevention and reversal of cerebral vasospasm by an endothelin- converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage. J Neurosurg 87:281-286, 1997.
9. Kwan AL, Lin CL, Chang CZ, Wu SC, Howng SL, Jeng AY. Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Neuroreport 13:197-199, 2002.
10. Santhanam AV, Smith LA, Akiyama M, Rosales AG, Bailey KR, Katusic ZS. Role of endothelial NO synthase phosphorylation in cerebrovascular protective effect of recombinant erythropoietin during subarachnoid hemorrhage-induced cerebral vasospasm. Stroke 36:2731-2737, 2005.
11. Foley PL, Cancer HH, Kassell NF, Kee KS. Prospective, randomized, double-blind trial of BQ123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys. J Neurosurg 83:503-509, 1995.
12. Zuccarello M, Soattin GB, Lewis AI, Breu V, Hallak H, Rapoport RM. Prevention of subarachnoid hemorrhage-induced cerebral vasospasm by an oral administration of endothelin receptor antagonists. J Neurosurg 84:503-507, 1996.
13. Jeng AY, Mulder P, Kwan AL, Battistini B. Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications. Can J Physiol Pharmacol 80:440-449, 2002.
14. Macdonald RL, Weir BKA, Chen GMH, Martin TP, Young JD. Mechanism of cerebral vasospasm following subarachnoid hemorrhage in monkeys. Can J Neurol Sci 19:419-427, 1992.