Expression of endostatin in human choroidal neovascular membranes secondary to age-related macular degeneration

Experimental Eye Research

Volumn 83, Issue 2, 2006, Pages 329-338

  Tatar, Olcay ^a   Shinoda, Kei ^b   Adam, Annemarie ^c   Rohrbach, Jens Martin ^a   Lucke, Klaus ^d   Henke Fahle, Sigrid ^a   Bartz Schmidt, Karl Ulrich ^a   Grisanti, Salvatore ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b NATIONAL HOSPITAL ORGANIZATION   (Japan)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF BREMEN   (Germany)

Author keywords

age related macular degeneration; angiogenesis; choroidal neovascularization; E selectin; endostatin

Indexed keywords

ANGIOGENESIS INHIBITOR; BIOLOGICAL MARKER; ENDOSTATIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; VASCULOTROPIN;

ADULT; ANGIOGENESIS; ARTICLE; BRUCH MEMBRANE; CELL PROLIFERATION; CHOROID; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROSCOPY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; STROMA; SUBRETINAL NEOVASCULARIZATION; UPREGULATION; VASCULARIZATION;

ADULT; ANTIGENS, CD; ANTIGENS, CD34; BRUCH MEMBRANE; CELL DIVISION; CELL MEMBRANE; CHOROID; CHOROIDAL NEOVASCULARIZATION; E-SELECTIN; ENDOSTATINS; ENDOTHELIAL CELLS; EYE PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; KI-67 ANTIGEN; MACULAR DEGENERATION; MALE; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; RECEPTORS, CELL SURFACE; RETROSPECTIVE STUDIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33744939462     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2005.12.017     Document Type: Article

References (45)

1. Abdollahi A., Lipson K.E., Sckell A., Zieher H., Klenke F., Poerschke D., Roth A., Han X., Krix M., Bischof M., Hahnfeldt P., Grone H.J., Debus J., Hlatky L., and Huber P.E. Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects. Cancer Res. 63 (2003) 8890-8898
2. Abdollahi A., Hahnfeldt P., Maercker C., Grone H.J., Debus J., Ansorge W., Folkman J., Hlatky L., and Huber P.E. Endostatin's antiangiogenic signaling network. Mol. Cells 13 (2004) 649-663
3. Amin R., Pulkin J.E., and Frank R.N. Growth factor localization in choroidal neovascular membranes of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 35 (1994) 3178-3188
4. Auricchio A., Behling K.C., Maguire A.M., O'Connor E.M., Bennett J., Wilson J.M., and Tolentino M.J. Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Mol. Ther 6 (2002) 490-494
5. Bhutto I.A., Kim S.Y., McLeod D.S., Merges C., Fukai N., Olsen B.R., and Lutty A. Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 45 (2004) 1544-1552
6. Dhanabal M., Ramchandran R., Waterman M.J., Lu H., Knebelmann B., Segal M., and Sukhatme V.P. Endostatin induces endothelial cell apoptosis. J. Biol. Chem. 274 (1999) 11721-11726
7. Dixelius J., Larsson H., Sasaki T., Holmqvist K., Lu L., Engstrom A., Timpl R., Welsh M., and Claesson-Welsh L. Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. Blood 95 (2000) 3403-3411
8. Dixelius J., Cross M., Matsumoto T., Sasaki T., Timpl R., and Claesson-Welsh L. Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Res. 62 (2002) 1944-1947
9. Ergun S., Kilic N., Wurmbach J.H., Ebrahimnejad A., Fernando M., Sevinc S., Kilic E., Chalajour F., Fiedler W., Lauke H., Lamszus K., Hammerer P., Weil J., Herbst H., and Folkman J. Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. Angiogenesis 4 (2001) 193-206
10. Eriksson K., Magnusson P., Dixelius J., Claesson-Welsh L., and Cross M.J. Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways. FEBS Lett. 536 (2003) 19-24
11. Folkman J. Endogenous angiogenesis inhibitors, 2004. APMIS 112 7-8 (2004) 496-507
12. Ferreras M., Felbor U., Lenhard T., Olsen B.R., and Delaisse J. Generation and degradation of human endostatin proteins by various proteinases. FEBS Lett. 486 (2000) 247-251
13. Fukai N., Eklund L., Marneros A.G., Oh S.P., Keene D.R., Tamarkin L., Niemela M., Ilves M., Li E., Pihlajaniemi T., and Olsen B.R. Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J 21 (2002) 1535-1544
14. Green W.R. The retina. In: Spencer W.H. (Ed). Ophthalmic Pathology: An Atlas and Textbook (1996), WB Saunders, Philadelphia 982-1051
15. Grisanti S., Canbek S., Kaiserling E., Adam A., Lafaut B., Gelisken F., Szurman P., Henke-Fahle S., Oficjalska-Mlynczak J., and Bartz-Schmidt K.U. Expression of endoglin in choroidal neovascularization. Exp. Eye. Res. 78 (2004) 207-213
16. Grossniklaus H.E., Ling J.X., Wallace T.M., Dithmar S., Lawson D.H., Cohen C., Elner V.M., Elner S.G., and Sternberg Jr. P. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol. Vis 21 (2002) 119-126
17. Kim Y.M., Jang J.W., Lee O.H., Yeon J., Choi E.Y., Kim K.W., Lee S.T., and Kwon Y.G. Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase 2. Cancer Res. 60 (2000) 5410-5413
18. Kivela T. Immunohistochemical staining followed by bleaching of melanin: a practical method for ophthalmic pathology. Br. J. Biomed. Sci. 52 (1995) 325-326
19. Kvanta A., Algvere P.V., Berglin L., and Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest. Ophthalmol. Vis. Sci. 37 (1996) 1929-1934
20. Lambert V., Wielockx B., Munaut C., Galopin C., Jost M., Itoh T., Werb Z., Baker A., Libert C., Krell H.W., Foidart J.M., Noel A., and Rakic J.M. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J. 17 (2003) 2290-2292
21. Lanzer R.C., and Raff M.C. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325 (1987) 253-257
22. Lee S.J., Jang J.W., Kim Y.M., Lee H.I., Jeon J.Y., Kwon Y.G., and Lee S.T. Endostatin binds to the catalytic domain of matrix metalloproteinase-2. FEBS Lett. 519 (2002) 147-152
23. Luo J., Lin J., Paranya G., and Bischoff J. Angiostatin upregulates E-selectin in proliferating endothelial cells. Biochem. Biophys. Res. Commun 245 3 (1998) 906-911
24. Luo J., Paranya G., and Bischoff J. Noninflammatory expression of E-selectin is regulated by cell growth. Blood 93 (1999) 3785-3791
25. Lutty G., Grunwald J., Majji A.B., Uyama M., and Yoneya S. Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration. Mol. Vis. 5 (1999) 35
26. Makitie T., Tarkkanen A., and Kivela T. Comparative immunohistochemical oestrogen receptor analysis in primary and metastatic uveal melanoma. Graefes Arch. Clin. Exp. Ophthalmol. 236 (1998) 415-419
27. Marneros A.G., Keene D.R., Hansen U., Fukai N., Moulton K., Goletz P.L., Moiseyev G., Pawlyk B.S., Halfter W., Dong S., Shibata M., Li T., Crouch R.K., Bruckner P., and Olsen B.R. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 14 (2004) 89-99
28. Martin G., Schlunck G., Hansen L.L., and Agostini H.T. Differential expression of angioregulatory factors in normal and CNV-derived human retinal pigment epithelium. Graefes Arch. Clin. Exp. Ophthalmol. 242 (2004) 321-326
29. Mori K., Ando A., Gehlbach P., Nesbitt D., Takahashi K., Goldsteen D., Penn M., Chen C.T., Mori K., Melia M., Phipps S., Moffat D., Brazzell K., Liau G., Dixon K.H., and Campochiaro P.A. Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin. Am. J. Pathol. 159 (2001) 313-320
30. Noma H., Funatsu H., Yamashita H., Kitano S., Mishima H.K., and Hori S. Regulation of angiogenesis in diabetic retinopathy: possible balance between vascular endothelial growth factor and endostatin. Arch. Ophthalmol. 120 (2002) 1075-1080
31. O'Reilly M.S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W.S., Flynn E., Birkhead J.R., Olsen B.R., and Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88 (1997) 277-285
32. Pepper M.S. Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 1104-1017
33. Sasaki T., Fukai N., Mann K., Gohring W., Olsen B.R., and Timpl R. Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. EMBO J. 17 (1998) 4249-4256
34. Sertie A.L., Sossi V., Camargo A.A., Zatz M., Brahe C., and Passos-Bueno M.R. Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome). Hum. Mol. Genet. 9 (2000) 2051-2058
35. Shen W.Y., Yu M.J., Barry C.J., Constable I.J., and Rakoczy P.E. Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat. Br. J. Ophthalmol. 82 (1998) 1063-1071
36. Skovseth D.K., Veuger M.J., Sorensen D.R., De Angelis P.M., and Haraldsen G. Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis and perivascular cell recruitment in vivo. Blood 105 (2005) 1044-1051
37. Takahashi K., Saishin Y., Saishin Y., Silva R.L., Oshima Y., Oshima S., Melia M., Paszkiet B., Zerby D., Kadan M.J., Liau G., Kaleko M., Connelly S., Luo T., and Campochiaro P.A. Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment. FASEB J. 17 (2003) 896-898
38. The Macular Photocoagulation Study Group. Argon laser photocoagulation for neovascular maculopathy: five year results from randomized clinical trials. Arch. Ophthalmol. 109 (1991) 1109-1114
39. Wada M., Ogata N., Otsuji T., and Uyama M. Expression of vascular endothelial growth factor and its receptor (KDR/flk-1) mRNA in experimental choroidal neovascularization. Curr. Eye Res. 18 (1999) 203-213
40. Wang W., Niu X.G., Xie L.X., and Dong X.G. Liposomes mediated plasmids encoding human endostatin inhibits endothelial cell proliferation. Zhonghua Yan Ke. Za. Zhi. 40 (2004) 321-325
41. Wang Y.S., Eichler W., Friedrichs U., Yafai Y., Hoffmann S., Yasukawa T., Hui Y.N., and Wiedemann P. Impact of endostatin on bFGF-induced proliferation, migration, and matrix metalloproteinase-2 expression/secretion of bovine choroidal endothelial cells. Curr. Eye Res. 30 (2005) 479-489
42. Yamaguchi N., Anand-Apte B., Lee M., Sasaki T., Fukai N., Shapiro R., Que I., Lowik C., Timpl R., and Olsen B.R. Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J 18 (1999) 4414-4423
43. Yeh D.C., Bula D.V., Miller J.W., Gragoudas E.S., and Arroyo J.G. Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapy. Invest. Ophthalmol. Vis. Sci. 45 (2004) 2368-2373
44. Yu Y., Moulton K.S., Khan M.K., Vineberg S., Boye E., Davis V.M., O'Donnell P.E., Bischoff J., and Milstone D.S. E-selectin is required for the antiangiogenic activity of endostatin. Proc. Natl. Acad. Sci. USA 101 (2004) 8005-8010
45. Zatterstrom U.K., Felbor U., Fukai N., and Olsen B.R. Collagen XVIII/endostatin structure and functional role in angiogenesis. Cell Struct. Funct. 25 (2000) 97-101