Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates

Journal of Virology

Volumn 80, Issue 12, 2006, Pages 5798-5806

  Biacchesi, Stéphane ^a   Pham, Quynh N ^a   Skiadopoulos, Mario H ^a   Murphy, Brian R ^a   Collins, Peter L ^a   Buchholz, Ursula J ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b MSC 8007 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN F; PROTEIN SULFHYDRYL GROUP; TRYPSIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AVIAN PNEUMOVIRUS; CERCOPITHECIDAE; CONTROLLED STUDY; HAMSTER; HUMAN METAPNEUMOVIRUS; IMMUNOGENICITY; LOWER RESPIRATORY TRACT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; UPPER RESPIRATORY TRACT; VIROGENESIS; VIRUS MUTANT; VIRUS PLAQUE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; CRICETINAE; DISEASE TRANSMISSION; IMMUNIZATION; METAPNEUMOVIRUS; MUTATION; TRYPSIN; VIRAL FUSION PROTEINS; VIRUS REPLICATION;

AVIAN METAPNEUMOVIRUS; CERCOPITHECUS AETHIOPS; CRICETINAE; HUMAN METAPNEUMOVIRUS; PRIMATES; RODENTIA;

EID: 33744921361     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00294-06     Document Type: Article

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