Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: A technical note

AAPS PharmSciTech

Volumn 7, Issue 2, 2006, Pages

  Viswanathan, Chelakara L ^a   Kulkarni, Sushrut K ^a   Kolwankar, Dhanashri R ^a  

^a BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

Mefenamic acid; Micromeritics; Nabumetone; Spherical agglomeration; Spherical crystallization

Indexed keywords

ALCOHOL; CARBON TETRACHLORIDE; CHLOROFORM; CYCLOHEXANE; HEXANE; MEFENAMIC ACID; N,N DIMETHYLFORMAMIDE; NABUMETONE; PHOSPHATIDYLCHOLINE; WATER; ALKANONE; ANTINEOPLASTIC AGENT; DRUG VEHICLE; MICROSPHERE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISTILLATION; DRUG ISOLATION; DRUG SOLUBILITY; DRUG SYNTHESIS; SCANNING ELECTRON MICROSCOPY; SOLVENT EXTRACTION; TABLET HARDNESS; TEMPERATURE MEASUREMENT; THERMOSTABILITY; VACUUM; X RAY DIFFRACTION; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; DRUG FORMULATION; MATERIALS TESTING; METHODOLOGY; PARTICLE SIZE; SOLUBILITY; VEHICLES;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BUTANONES; CRYSTALLIZATION; DRUG COMPOUNDING; MATERIALS TESTING; MEFENAMIC ACID; MICROSPHERES; PARTICLE SIZE; SOLUBILITY; VEHICLES; WATER;

EID: 33744909400     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070231     Document Type: Article

References (7)

1. Atkinson RM, Belford C, Tomich EG. Effect of particle size on blood Griseofulvin levels in man. Nature. 1962;193:588-589.
2. Prescott LF, Steel RF, Ferrier WR. The effect of particle size on the absorption of Phenacetin in man. A correlation between plasma concentration of phenacetin and effects on the central nervous system. Clin Pharmacol Ther. 1970;11:496-504.
3. Kawashima Y, Okumara M, Takenaka H. A novel agglomeration technique to transform a microcrystalline drug into an agglomerated form during crystallization. Science. 1982;216:1127-1128.
4. Kawashima Y, Okumara M, Takenaka H, Kojwa A. Direct preparation of spherically agglomerated salicylic acid crystals during crystallization. J Pharm Sci. 1984;73:1535-1538.
5. Gordon MS, Chowhan LT. Manipulation of naproxen particle morphology via the spherical crystallization technique to achieve a directly compressible raw material. Drug Dev Ind Pharm. 1990;16:1279-1290.
6. Sano A, Kuriki T, Handa T, Takeuchi H, Kawashima Y. Particle design of Tolbutamide in the presence of soluble polymer or surfactant by the spherical crystallization technique: improvement of dissolution rate. J Pharm Sci. 1987;76:471-474.
7. Kotteke MK, Rudnic EM. Tablet Dosage forms. In: Banker GS, Rhodes CT, eds. Modern Pharmaceutics. 4th ed. New York, NY: Marcel Dekker; 2002:291-333.