Tamoxifen-induced severe hypertriglyceridaemia and acute pancreatitis

Clinical Drug Investigation

Volumn 26, Issue 5, 2006, Pages 297-302

  Alagozlu, Hakan ^a   Cindoruk, Mehmet ^a   Unal, Selahattin ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

GEMFIBROZIL; GLUCONATE CALCIUM; INSULIN; PETHIDINE; TAMOXIFEN;

ABDOMINAL RADIOGRAPHY; ACUTE PANCREATITIS; ADULT; ALCOHOL ABUSE; ANAMNESIS; ARTERIAL GAS; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DIABETES MELLITUS; DISEASE SEVERITY; DRUG USE; DRUG WITHDRAWAL; FEMALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HYPERTRIGLYCERIDEMIA; HYPOKALEMIA; LABORATORY TEST; PHYSICAL EXAMINATION; PREGNANCY; PRIORITY JOURNAL; RISK FACTOR; THYROID FUNCTION TEST;

ACUTE DISEASE; ANTILIPEMIC AGENTS; ESTROGEN ANTAGONISTS; FEMALE; GEMFIBROZIL; HUMANS; HYPERTRIGLYCERIDEMIA; HYPOLIPIDEMIC AGENTS; INSULIN; MIDDLE AGED; PAIN; PANCREATITIS; TAMOXIFEN; TREATMENT OUTCOME; VOMITING;

EID: 33744906039     PISSN: 11732563     EISSN: 11732563     Source Type: Journal    
DOI: 10.2165/00044011-200626050-00007     Document Type: Article

References (31)

1. Shapiro CL, Recht A. Side effects of adjuvant treatment of breast cancer. N Engl J Med 2001; 344: 1997-2008
2. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med 1998; 339: 1609-18
3. Hozumi Y, Kawano M, Saito T, et al. Effect of tamoxifen on serum lipid metabolism. J Clin Endocrinol Metab 1998; 83: 1633-5
4. Koshizuka K, Serizawa M, Hasuda N, et al. Tamoxifen-induced severe hypertriglyceridemia: report of 3 cases. Gan To Kagaku Ryoho 2004; 31 (7): 1109-12
5. Liu CL, Yang TL. Sequential changes in serum triglyceride levels during adjuvant tamoxifen therapy in breast cancer patients and the effect of dose reduction. Breast Cancer Res Treat 2003; 79 (1): 11-6
6. Artac M, Sari R, Altunbas H, et al. Asymptomatic acute pancreatitis due to tamoxifen-induced severe hypertriglyceridemia in a patient with diabetes mellitus and breast cancer. J Chemother 2002 Jun; 14 (3): 309-11
7. Noguchi M, Taniya T, Tajiri K, et al. Fatal hyperlipaemia in a case of metastatic breast cancer treated by tamoxifen. Br J Surg 1987; 74: 586-7
8. Colls BM, George PM. Severe hypertriglyceridaemia and hypercholesterolaemia associated with tamoxifen use. Clin Oncol 1998; 10: 270-1
9. Elisaf MS, Nakou K, Liamis G, et al. Tamoxifen-induced severe hypertriglyceridemia and pancreatitis. Ann Oncol 2000; 11: 1067-9
10. Fan ST, Lai EC, Mok FP, et al. Prediction of the severity of acute pancreatitis. Am J Surg 1993; 166 (3): 262-8
11. Dimagno EP, Chari S: Acute pancreatitis. In: Feldman M, Friedman LS, Sleisenger MH, eds. Gastrointestinal and liver Disease: Pathophysiology/ Diagnosis/Management 7th ed. WB Saunders Co, Philadelphia, 2002: 913-41
12. Toouli J, Brooke-Smith M, Bassi C, et al. Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol 2002; 17 Suppl: S15-39
13. Hozumi Y, Kawano M, Miyata M. Severe hypertriglyceridemia caused by tamoxifen treatment after breast cancer surgery. Endocr J 1997; 44: 745-9
14. Lin HH, Hsu CH, Chao YC. Tamoxifen-induced severe acute pancreatitis: a case report. Dig Dis Sci 2004; 49: 997-9
15. Walsh BW, Schiff I, Rosner B, et al. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991; 325: 1196-204
16. Kanel KT, Wolmark N, Thompson PD. Delayed severe hypertriglyceridemia from tamoxifen. N Engl J Med 1997; 337: 281
17. Bagdade JD, Wolter J, Subbaiah PV, et al. Effects of tamoxifen treatment on plasma lipids and lipoprotein lipid composition. J Clin Endocrinol Metab 1990; 70: 1132-5
18. Brun LD, Gagne C, Rousseau C, et al. Severe lipemia induced by tamoxifen. Cancer 1986; 57: 2123-6
19. Glueck CJ, Lang J, Hamer T, et al. Severe hypertriglyceridemia and pancreatitis when estrogen replacement therapy is given to hypertriglyceridemic women. J Lab Clin Med 1994; 123: 59-64
20. Mikhailidis DP, Ganotakis ES, Georgoulias VA, et al. Tamoxifen-induced hypertriglyceridaemia: seven case reports and suggestions for remedial action. Oncol Rep 1997; 4: 625-8
21. Milionis HJ, Liberopoulos EN, Elisaf MS. Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus Diabetes Metab 2001; 27 (2 Pt 1): 160-3
22. Henzen C, Rock M, Schnieper C, et al. Heparin and insulin in the treatment of acute hypertriglyceridemia-induced pancreatitis. Schweiz Med Wochenschr 1999; 129: 1242-8
23. Malmstrom R, Packard CJ, Caslake M, et al. Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects. Diabetes 1998; 47: 779-87
24. Jabbar MA, Zuhri-Yafi MI, Larrea J. Insulin therapy for a nondiabetic patient with severe hypertriglyceridemia. J Am Coll Nutr 1998; 17: 458-61
25. Johnson SG, Ellis CJ, Levitt MD. Mechanism of increased renal clearance of amylase/creatinine in acute pancreatitis. N Engl J Med 1976; 295(22): 1214-7
26. Sachdeva CK, Bank S, Greenberg R, et al. Fluctuations in serum amylase in patients with macroamylasemia. Am J Gastroenterol 1995; 90 (5): 800-3
27. Yadav D, Nair S, Norkus EP, et al. Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities. Am J Gastroenterol 2000; 95 (11): 3123-8
28. Nair S, Yadav D, Pitchumoni CS. Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA. Am J Gastroenterol 2000; 95 (10): 2795-800
29. Lennertz A, Parhofer KG, Samtleben W, et al. Therapeutic plasma exchange in patients with chylomicronemia syndrome complicated by acute pancreatitis. Ther Apher 1999; 3: 227-33
30. Jonkers GH. Tamoxifen and hypertriglyceridemia. Neth J Med 1999; 55 (2): 84-5
31. Taira M, Takasu N, Komiya I. Severe hypertriglyceridemia induced by tamoxifen. Nippon Ronen Igakkai Zasshi 1998; 35 (11): 858-60