In vivo distribution and pharmacokinetics of dexamethasone sodium phosphate thermosensitive in situ gel following intratympanic injection

Journal of Sichuan University (Medical Science)

Volumn 37, Issue 3, 2006, Pages 456-459

  Chen, Gang ^a   Hou, Shi Xiang ^a   Liu, Jun ^a   Luan, Jian Gang ^a   Zhang, Yu ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Cochlea; Dexamethasone; Intratympanic injection; Pharmacokinetics; Thermosensitive in situ gel

Indexed keywords

DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; POLOXAMER;

AREA UNDER THE CURVE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG ADSORPTION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; GEL; GUINEA PIG; HEAT SENSITIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INNER EAR; MEAN RESIDENCE TIME; NONHUMAN; PERILYMPH; PLASMA;

EID: 33744825450     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Juhn SK, Robertson D, Papastavros T, et al. Biochemical aspects of inner ear fluids and possible implications for pharmacological treatment. Scand Audiol Suppl, 1986;26:7-10.
2. Kaplan DM, Nedzelski JM, Chen JM, et al. Intratympanic gentamicin for the treatment of unilateral Meniere's disease. Laryngoscope, 2000;110(8):1298-1305.
3. Chandrasekhar SS, Bubinstein RY, Kwartler JA, et al. Dexamethasone pharmacokinetics in the inner ear: Comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg, 2000;122(4):521-528.
4. Parnes LS, Sun AH, Freeman DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope, 1999;109(7 Pt 2):1-17.
5. Bergmann K, Haupt H, Scheibe F, et al. Der verschlu des aquaeductus cochleaefur perilymphuntersuchungen am meerschweinchen [Blockage of cochlear aqueduct for examination of perilymph (guinea pig) (author's transl)]. Arch Otorhinolaryngol, 1979;224(3-4):257-265.