Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine

Journal of Medicinal Chemistry

Volumn 49, Issue 11, 2006, Pages 3383-3394

  Nguyen, Tuan Minh ^a   Sittisombut, Chavalit ^a   Boutefnouchet, Sabrina ^a   Lallemand, Marie Christine ^a   Michel, Sylvie ^a   Koch, Michel ^a   Tillequin, François ^a   Mazinghien, Romain ^b   Lansiaux, Amélie ^b   David Cordonnier, Marie Hélène ^b   Pfeiffer, Bruno ^c   Kraus Berthier, Laurence ^c   Léonce, Stéphane ^c   Pierré, Alain ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIACETOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[A]PYRANO[3,2 H]ACRIDIN 7 ONE; 1,2 DIACYLOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[A]PYRANO[3,2 H]ACRIDIN 7 ONE DERIVATIVE; 3,5 DIMETHOXYACETANILIDE; ACETANILIDE DERIVATIVE; ACRIDINE DERIVATIVE; ACRONINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN KB 3 1; CELL STRAIN L1210; COLON ADENOCARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; COVALENT BOND; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; MURINE LEUKEMIA; NONHUMAN; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION;

ACRIDINES; ACRONINE; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NEOPLASM TRANSPLANTATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 33744824657     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0602007     Document Type: Article

References (37)

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