Bactericidal effects of the Fotolon (chlorin e6) on gram-negative and gram-positive strains isolated from wound infections

Advances in Clinical and Experimental Medicine

Volumn 15, Issue 2, 2006, Pages 279-283

  Drulis Kawa, Zuzanna ^a,b   Bednarkiewicz, Artur ^c   Bugla, Gabriela ^a   Strek, Wiesław ^c   Doroszkiewicz, Włodzimierz ^a  

^a UNIVERSITY OF WROC AW   (Poland)

^b J Korczak Memorial Children's Hospital Wroclaw   (Poland)

^c INSTITUTE OF LOW TEMPERATURE AND STRUCTURE RESEARCH   (Poland)

Author keywords

Fotolon (chlorin e6); Gram negative bacteria; Gram positive bacteria; Photodynamic inactivation

Indexed keywords

FOTOLON; TALAPORFIN;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; KLEBSIELLA PNEUMONIAE; LASER; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PHOTOSENSITIZATION; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS PUTIDA; PSEUDOMONAS STUTZERI; STAPHYLOCOCCUS AUREUS; WILD TYPE; WOUND INFECTION;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 33744819444     PISSN: 1230025X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Emori TG, Gaynes RP: An overview of nosocomial infections, including the role of microbiology laboratory. Clin Microb Rev 1993, 4, 428-442.
2. Mayon-White RT, Ducel G, Kereselidze T: An international survey of the prevalence of hospital-aquired infection. J. Hosp Infect 1988, 2, 11 Suppl A: 43-48.
3. NNIS System: National Nosocomial Infections Surveillance (NNIS) report, data summary from October 1986-April 1996, issued May 1996. A report from the National Nosoconial Infections Surveillance (NNIS) System. Am J Infect Control 1996, 5, 380-388.
4. Revathi G, Puri J, Jain BK: Bacteriology of bums. Burns 1998, 4, 347-359.
5. Siami G, Chrístou N, Eiseman I, Tack KJ and the Clinafloxacin Severe Skin And Soft Tissue Infections Study Group: Clinafloxacin versus Piperacillin-Tazobactam in Treatment of Patients with Severe Skin and Soft Tissue Infections. Antimicrob. Agents Chemother 2001, 45, 525-531.
6. Carmeli Y, Castro J, Eliopoulos GM, Samore MH: Clinical Isolation and Resistance Patterns of and Superinfection with 10 Nosocomial Pathogens after Treatment with Ceftriaxone versus Ampicillin-Sulbactam. Antimicrob. Agents Chemother 2001, 45, 275-279.
7. Bell JM, Turnidge JD and SENTRY APAC Participants: High Prevalence of Oxacillin-Resistant Staphy-lococcus aureus Isolates from Hospitalized Patients in Asia-Pacific and South Africa: Results from SENTRY Antimicrobial Surveillance Program, 1998-1999. Antimicrob. Agents Chemother 2002, 46, 879-881.
8. Harbarth S, Cosgrove S, Carmeli Y: Effects of Antibiotics on Nosocomial Epidemiology of Vancomycin-Resistant Enterococci. Antimicrob. Agents Chemother 2002, 46, 1619-1628.
9. Livermore DM, Woodford N: Carbapenemases: a problem in waiting? Curr Opin Microbiol 2000, 3, 489-495.
10. Livermore DM: Of Pseudomonas, porins, pumps and carbapenems. J Antimicrob Chemother 2001, 47, 247-250.
11. Quinn JP, Dudek EJ, DiVincenzo CA, Lucks DA, Lerner SA: Emergence of resistance to imipenem. during therapy for Pseudomonas aeruginosa infections. J Infect Dis 1986, 154, 289-294.
12. Senda K, Arakawa Y, Nakashima K, Ito H, Ichiyama S, Shimokata K, Kato N, Ohta M: Multifocal outbreaks of metallo-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum β-lactams, including carbapenems. Antimicrob Agents Chemother 1996, 40, 349-353.
13. Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T: Optical monitoring and treatment of potentially lethal wound infections in vivo. J Infect Dis 2003, 187, 1717-1725.
14. Soukos NS, Wilson M, Burns T, Speight PM: Photodynamic effects of toluidine blue on human oral keratinocytes and fibroblasts and Streptococcus sanguis evaluated in vitro. Lasers Surg Med 1996, 18, 253-259.
15. Embleton ML, Sean PN, Cookson BD, Wilson M: Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate. J Antimicrob Chemother 2002, 50, 857-864.
16. Soncin M, Fabris C, Busetti A, Dei D, Nistri D, Roncucci G, Jori G: Approaches to selectivity in the Zn(II)-phthalocyanine-photosensitized inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochem Photobiol Sci 2002, 10, 815-919.
17. Ehrenberg B, Malik Z, Nitzan Y: Fluorescence spectral changes of hematoporphyrin derivative upon binding to lipid vesicles Staphylococcus aureus and Escherichia coli cells. Photochem Photobiol 1985, 41, 429-435.
18. Malik Z, Ladan H, Nitzan Y: Photodynamic inactivation of Gram-negative bacteria Problems and possible solutions. J Photobiol Photochem B: Biol 1992, 1, 262-266.
19. Bertoloni G, Rossi F, Valduga G, Jori G, van Lier J: Photosensitiseing activity of water- and lipid-soluable phthalocyanines on Escherichia coli. FEMS Microbiol Letters 1990, 59, 149-55.
20. Nitzan Y, Malik Z, Ehrenberg B: Photosensitization of microbial cells. In Photobiology: the Science and its Applications. Eds.: Riklis E. Plenum Press, New York, 815-820.
21. Merchat M, Bertoloni G, Giacomoni P, Villanueva A, Jori G: Meso-substituted cationic porphyrins as efficient photosensitizers of Gram-positive and Gram-negative bacteria. J Photochem Photobiol 1996, 32, 153-157.
22. Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, HasanT: Polycationic photosensitiser conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J Antimicrob Chemother 2002, 49, 941-951.
23. Minnock A, Vernon DI, Schofield J, Griffiths J, Parish JH, Brown ST: Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both Gram-negative and Gram-positive bacteria. J Photochem Photobiol B: Biol 1996, 32, 159-164.
24. Vaara M: Agents that increase the permeability of the outer membrane. Microbiol Rev 1992, 56, 395-411.
25. Berthiaume F, Reiken SR, Toner M, Tompkins RG, Yarmush ML: Antibody-targeted photolysis of bacteria in vivo. Bio-Technology 1994, 12, 703-706.
26. Friedberg JS, Tompkins RG, Rakestraw SL, Warren SW, Fischman AJ, Yarmush ML: Antibody-targeted photolysis. Bacteriocidal effects of Sn (IV) chlorin e6-dextran-monoclonal antibody conjugates. Ann NY Acad Sci 1991, 618, 383-393.
27. Parkhots MV, Knyukshto VN, Isakov GA, Petrov PT, Lepeshkevich SV, Khairullina AY, Dzhagarov BA: Spectral-luminescent studies of the "photolon" photosensitizer in model media and in blood of oncological patients. J App Spectr 2003, 70, 921-926.