Changes in expression of GABAA α4 subunit mRNA in the brain under anesthesia induced by volatile and intravenous anesthetics

Neurochemical Research

Volumn 31, Issue 3, 2006, Pages 439-448

  Sekine, Shusuke ^a   Matsumoto, Shohei ^a   Issiki, Atsushi ^a   Kitamura, Taiko ^a   Yamada, Jinzo ^a   Watanabe, Yasuo ^b  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

c fos like protein; C57BL 6J mouse; GABAA receptor 4 subunit mRNA; Midazolam; Propofol; Volatile anesthetic

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; ISOFLURANE; MESSENGER RNA; MIDAZOLAM; MIDAZOLAM MALEATE; NITROUS OXIDE; OXYGEN; PENTOBARBITAL; PROPOFOL; PROTEIN C FOS; ALPHA4 SUBUNIT, GABA A RECEPTOR; ALPHA4 SUBUNIT, GABA-A RECEPTOR;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; DIENCEPHALON; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIGHTING REFLEX; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; DRUG EFFECT; GENETICS; HISTOLOGY; METABOLISM;

ANESTHESIA; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ANIMALS; BRAIN; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GABA-A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33744817640     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-005-9024-4     Document Type: Article

References (30)

1. Mohler H, Alger BE (eds) (2001) Pharmacology of GABA and glycine neurotransmission. Springer, Berlin
2. Hadigham KL, Harkness PC, McKernan RM, Quirk K, Bourdelles BL, Home AL, Barnard JA, Ragan CI, Whiting PJ (1992) Stable expression of mammalian type A γ-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites. Neurobiol 89:6378-6382
3. Sur C, Farrar SJ, Kerby J, Whiting PJ, Atack JR, McKernan RM (1999) Preferential coassembly of α4 and δ subunits of the γ-aminobutyric acid A receptor in rat thalamus. Mol Pharmacol 56:110-115
4. Simpson VJ, Blednov Y (1998) Propofol produces differences in behavior but not chloride channel function between selected lines of mice. Anesth Analg 82:327-331
5. Backberg M, Ultenius C, Fritschy JM, Meister B (2004) Cellular localization of GABA receptor α subunit immunoreactivity in the rat hypothalamus. Relationship with neurons containing exogenic or anorexigenic peptides. J Neuroendocrinol 16:589-604
6. A receptors containing the α4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ. J Neurochem 69:806-814
7. A-receptor subtypes really occur in the brain? Trends Neurosci 19:139-143
8. Liu ZF, Burt DR (1998) A synthetic standard for competitive RT-PCR quantitation of 13 GABA receptor type A subunit mRNAs in rats and mice. J Neurosci Meth 85:89-98
9. Bencsits E, Ebert V, Tretter V, Seighart W (1999) A significant part of native γ-aminobutyric acid A receptors containing α4 subunits do not contain γ or δ subunits. J Biol Chem 28:19613-19616
10. Barnard EA, Skolnic P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) International union of pharmacology. XV subtypes of γ-aminobutyric acid A receptors. Classification on the basis of subunit structure and receptor function. Pharmacol Rev 50(2):291-313
11. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194
12. A receptors α4 subunit to electoroshock seizures. Neurosci Lett 250:17-20
13. A receptor α1 and α4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats. Exp Neurol 154:213-223
14. A receptor subunit mRNAs in the rat brain. I. telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040-1062
15. A receptors. Mol Neurobiol 18:35-86
16. A receptor α4-subunit expression: possible relevance to alcohol dependence. J Neurochem 68:2485-2492
17. Low K, Crestani F, Keist R, Benke D, Bruning I, Benson JA, Fritschy JM, Rulicke T, Bluethmann H, Mohlar H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134
18. A receptors α4 subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells. Mol Pharmacol 63:896-907
19. A receptors α4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392:926-930
20. A receptor subunit mRNAs. Use of quantitative PCR methodology. Brain Res Bull 30:691-693
21. A receptor α4 subunit in DBA/2J and C57BL/6J mice. Brain Res Bull 47:643-647
22. Watanabe Y, Hayashi H, Nishimura T, Yoshimura Y, Shibuya T (1992) Alteration of synaptosomal membrane bound calcium levels in the different brain regions under pentobarbital- and ethanol-induced hypnosis. Neurosciences 18:37-42
23. A receptor α4 subunit creates a severely truncated mRNA. Brain Res Bull 58:447-454
24. Yajima T, Tagihashi A, Kameshima H, Kobayashi D, Furuya D, Hirata K, Watanabe N (1998) Quantitative reverse transcription-PCR assay of the TaqMan fluorogenic detection system. Clin Chem 44(12):2441-2445
25. Aloisi AM, Zimmermann M, Herdegen T (1997) Sex-dependent effects of formalin and restraint on c-fos expression in the septum and hippocampus of the rat. Neurosciences 81:951-958
26. Yamada Y, Watanabe Y, Zhang J, Haraoka J, Ito H (2002) Changes in cortical and cerebellar bcl-2 mRNA levels in the developing hydrocephalic rat (LEW-HYR) as measured by a real time quantified RT-PCR. Neurosciences 114:165-171
27. Aloisi AM, Ceccarelli I, Herdegen T (2000) Gonadectomy and persistent pain differently affect hippocampal c-fos expression in male and female rats. Neurosci Lett 281:29-32
28. Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL (1998) Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that for isoflurane. Mol Pharmcol 53:530-538
29. Hamaya Y, Takeda T, Dohi S, Nakashima S, Nozawa Y (2000) The effects of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat. Anesth Analg 90:1177-1183
30. Jenkins TA, Amin E, Brown MW, Aggleton JP (2006) Changes in immediate early gene expression in the rat brain after unilateral lesions of the hippocampus. Neurosciences 137:747-759