Hypoxia induced chemokine expression in nasal epithelial cells: Development of an in vitro model for chronic rhinosinusitis

Altex

Volumn 23, Issue 2, 2006, Pages 59-63

  Pahl, Andreas ^a   Szelenyi, Stefan ^a   Brune, Kay ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

3R; Chemokines; Epithelial cells; Hypoxia; Inflammation; Rhinosinusitis

Indexed keywords

CHEMOKINE; DEXAMETHASONE;

ANIMAL TESTING REFINEMENT; ANIMAL TESTING REPLACEMENT; ARTICLE; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECT; DRUG SENSITIVITY; EOSINOPHIL; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; INFLAMMATION; LEUKOCYTE MIGRATION; NEUTROPHIL CHEMOTAXIS; NOSE CONGESTION; NOSE MUCOSA; PARANASAL SINUS; PATHOPHYSIOLOGY; RHINOSINUSITIS; T LYMPHOCYTE ACTIVATION;

ANOXIA; CELLS, CULTURED; CHEMOKINES; CHEMOTAXIS; CHRONIC DISEASE; DEXAMETHASONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; GLUCOCORTICOIDS; GRANULOCYTES; HUMANS; MODELS, BIOLOGICAL; NASAL MUCOSA; RHINITIS; SINUSITIS;

EID: 33744813253     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Bachert, C., Hormann, K., Mosges, R. et al. (2003). An update on the diagnosis and treatment of sinusitis and nasal polyposis. Allergy 58, 176-191.
2. Barnes, P. J. (1998). Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond) 94, 557-572.
3. Brook, I. (2003). Acute and chronic frontal sinusitis. Curr. Opin. Pulm. Med. 9, 171-174.
4. Kaliner, M. A., Osguthorpe, J. D., Fireman, P. et al. (1997). Sinusitis: bench to bedside. Current findings, future directions. Otolaryngol. Head Neck. Surg. 116, S1-20.
5. Kennedy, D. W. (2004). Pathogenesis of chronic rhinosinusitis. Ann. Otol. Rhinol. Laryngol. Suppl. 193, 6-9.
6. Matsune, S., Kono, M., Sun, D. et al. (2003). Hypoxia in paranasal sinuses of patients with chronic sinusitis with or without the complication of nasal allergy. Acta Otolaryngol. 123, 519-523.
7. Meltzer, E. O., Hamilos, D. L., Hadley, J. A. et al. (2004). Rhinosinusitis: establishing definitions for clinical research and patient care. J. Allergy Clin. Immunol. 114, 155-212.
8. Mucha, S. M., and Baroody, F. M. (2003). Sinusitis update. Curr. Opin. Allergy Clin. Immunol. 3, 33-38.
9. Murray, J., Ward, C., O'Flaherty, J. T. et al. (2003). Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. Br. J. Pharmacol. 139, 388-398.
10. Nguyen, L. H., Fakhri, S., Frenkiel, S. and Hamid, Q. A. (2003). Molecular immunology and immunotherapy for chronic sinusitis. Curr. Allergy Asthma Rep. 3, 505-512.
11. Pawankar, R., Nonaka, M., Yamagishi, S. and Yagi, T. (2004). Pathophysiologic mechanisms of chronic rhinosinusitis. Immunol. Allergy Clin. North Am. 24, 75-85.
12. Sabroe, I., Lloyd, C. M., Whyte, M. K. et al. (2002). Chemokines, innate and adaptive immunity, and respiratory disease. Eur. Respir. J. 19, 350-355.
13. Serhan, C. N. and Savill, J. (2005). Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6, 1191-1197.
14. Takizawa, H. (2005). Bronchial epithelial cells in allergic reactions. Curr. Drug Targets Inflamm. Allergy 4, 305-311.
15. van Cauwenberge, P., Van Hoecke, H., Vandenbulcke, L. et al. (2005). Glucocorticosteroids in allergic inflammation: clinical benefits in allergic rhinitis, rhinosinusitis, and otitis media. Immunol. Allergy Clin. North Am. 25, 489-509, vi.