Randomised clinical trial, observational study and assessment of cost-effectiveness of the treatment of varicose veins (REACTIV trial)

Health Technology Assessment

Volumn 10, Issue 13, 2006, Pages 1-114

  Michaels, J A ^a   Campbell, W B ^b   Brazier, J E ^c   MacIntyre, J B ^b   Palfreyman, S J ^a   Ratcliffe, J ^c   Rigby, K ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ROYAL DEVON AND EXETER HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AESCULUS HIPPOCASTANUM EXTRACT; ANTIBIOTIC AGENT; DIHYDROERGOTAMINE; DOBESILATE CALCIUM; FLUNARIZINE; HEPTAMINOL; HOMEOPATHIC AGENT; OXERUTIN DERIVATIVE; PLACEBO; POIKIVEN; RUTOSIDE DERIVATIVE; SCLEROSING AGENT; TETRADECYL SULFATE SODIUM; UNCLASSIFIED DRUG; WARFARIN;

APPLICATION SITE PIGMENTATION CHANGE; BLISTER; CHEST INFECTION; CLINICAL TRIAL; COMPRESSION THERAPY; CONSERVATIVE TREATMENT; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DEEP VEIN THROMBOSIS; DISEASE SEVERITY; DRUG COST; DRUG EFFICACY; DRUG TOLERABILITY; ECONOMIC EVALUATION; HEALTH CARE COST; HUMAN; HYDROTHERAPY; INFORMATION PROCESSING; INJECTION SITE ULCER; LASER SURGERY; LEG VARICOSIS; META ANALYSIS; MULTIVARIATE ANALYSIS; NATIONAL HEALTH SERVICE; OBSERVATIONAL STUDY; PATIENT SATISFACTION; PHLEBECTOMY; PHLEBITIS; QUALITY ADJUSTED LIFE YEAR; QUALITY OF LIFE; RADIOFREQUENCY ABLATION; REVIEW; SCLEROTHERAPY; SURGICAL INFECTION; SYSTEMATIC REVIEW; TOURNIQUET; TREATMENT OUTCOME; UNIVARIATE ANALYSIS; VARICOSIS; VEIN LIGATION; VEIN STRIPPING; VENOUS REFLUX; VISUAL ANALOG SCALE;

EID: 33744808277     PISSN: 13665278     EISSN: None     Source Type: Journal    
DOI: 10.3310/hta10130     Document Type: Review

References (220)

1. Franks PJ, Wright DD, Moffatt CJ, Stirling J, Fletcher AE, Bulpitt CJ, et al. Prevalence of venous disease: a community study in west London. Eur J Surg 1992;158:143-7.
2. Callam MJ. Epidemiology of varicose veins. Br J Surg 1994;81:167-73.
3. Evans CJ, Allan PL, Lee AJ, Bradbury AW, Ruckley CV, Fowkes FG. Prevalence of venous reflux in the general population on duplex scanning: the Edinburgh vein study. J Vasc Surg 1998;28:767-76.
4. Evans CJ, Fowkes FG, Ruckley CV, Lee AJ. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Commun Health 1999;53:149-53.
5. Department of Health. HES statistics. URL: http://www.dh.gov.uk/PublicationsAndStatistics/Statistics/ HospitalEpisodeStatistics/HESFreeData/HESFreeDataList/fs/ en?CONTENT_ID=4028328&chk=6HBoYS. Accessed 2004.
6. Palfreyman SJ, Drewery-Carter K, Rigby K, Michaels JA, Tod AM. Varicose veins: a qualitative study to explore expectations and reasons for seeking treatment. J Clin Nurs 2004;13:332-40.
7. Bradbury A, Evans C, Allan P, Lee A, Ruckley CV, Fowkes FG. What are the symptoms of varicose veins? Edinburgh vein study cross sectional population survey. BMJ 1999;318:353-6.
8. Speakman MJ, Collin J. Are swelling and aching of the legs reduced by operation on varicose veins? Br Med J (Clin Res Ed) 1986;293:105-6.
9. Bergqvist D, Jaroszewski H. Deep vein thrombosis in patients with superficial thrombophlebitis of the leg. Br Med J (Clin Res Ed) 1986;292:658-9.
10. Skillman JJ, Kent KC, Porter DH, Kim D. Simultaneous occurrence of superficial and deep thrombophlebitis in the lower extremity. J Vasc Surg 1990;11:818-23.
11. Jorgensen JO, Hanel KC, Morgan AM, Hunt JM. The incidence of deep venous thrombosis in patients with superficial thrombophlebitis of the lower limbs. J Vasc Surg 1993;18:70-3.
12. Chengelis DL, Bendick PJ, Glover JL, Brown OW, Ranval TJ. Progression of superficial venous thrombosis to deep vein thrombosis. J Vasc Surg 1996;24:745-9.
13. Blumenberg RM, Barton E, Gelfand ML, Skudder P, Brennan J. Occult deep venous thrombosis complicating superficial thrombophlebitis. J Vasc Surg 1998;27:338-43.
14. NICE. Referral practice: a guide to appropriate referral from general to specialist services. URL: http://www.nice.org.uk/article.asp?a=1178. Accessed 2000.
15. Labropoulos N, Delis K, Nicolaides AN, Leon M, Ramaswami G. The role of the distribution and anatomic extent of reflux in the development of signs and symptoms in chronic venous insufficiency. J Vasc Surg 1996;23:504-10.
16. Shami SK, Sarin S, Cheatle TR, Scurr JH, Smith PD. Venous ulcers and the superficial venous system. J Vasc Surg 1993;17:487-90.
17. Iafrati MD, Welch H, O'Donnell TF, Belkin M, Umphrey S, McLaughlin R. Correlation of venous noninvasive tests with the Society for Vascular Surgery/International Society for Cardiovascular Surgery clinical classification of chronic venous insufficiency. J Vasc Surg 1994;19:1001-7.
18. Witham Braintree and Halstead Care Trust. Minutes of Board Meeting, 3 September 2003. URL: http://www.braintreecaretrust.nhs.uk/WBHCareTrust/intra/documents/ agendas/minutes%20of%20board%20meeting%203%20sept.doc
19. Court C. Survey shows widespread rationing in NHS. BMJ 1995;311:1453a-1454a.
20. Cheatle T, Shields D, Scurr J, Coleridge-Smith P. The rational management of varicose veins. Health Trends 1991;23:152-3.
21. Kitslaar PJ, Rutgers PH. Varicose veins and the vascular surgeon: from nuisance to challenge. Eur J Vasc Surg 1993;7:109-12.
22. Bladin C, Royle JP. Acquisition of skills required for use of Doppler ultrasound and the assessment of varicose veins. Aust N Z J Surg 1987;57:225-6.
23. Kim J, Richards S, Kent PJ. Clinical examination of varicose veins - a validation study. Ann R Coll Surg Engl 2000;82:171-5.
24. Campbell WB, Niblett PG, Ridler BM, Peters AS, Thompson JF. Hand-held Doppler as a screening test in primary varicose veins. Br J Surg 1997; 84:1541-3.
25. Bradbury AW, Stonebridge PA, Ruckley CV, Beggs I. Recurrent varicose veins: correlation between preoperative clinical and hand-held Doppler ultrasonographic examination, and anatomical findings at surgery. Br J Surg 1993; 80:849-51.
26. Chan A, Chisholm I, Royle JP. The use of directional Doppler ultrasound in the assessment of saphenofemoral incompetence. Aust N Z J Surg 1983;53:399-402.
27. Hoare MC, Royle JP. Doppler ultrasound detection of saphenofemoral and saphenopopliteal incompetence and operative venography to ensure precise saphenopopliteal ligation. Aust N Z J Surg 1984;54:49-52.
28. McIrvine AJ, Corbett CR, Aston NO, Sherriff EA, Wiseman PA, Jamieson CW. The demonstration of saphenofemoral incompetence; Doppler ultrasound compared with standard clinical tests. Br J Surg 1984;71:509-10.
29. Kent PJ, Weston MJ. Duplex scanning may be used selectively in patients with primary varicose veins. Ann R Coll Surg Engl 1998;80:388-93.
30. Pleass HC, Holdsworth JD. Audit of introduction of hand-held Doppler and duplex ultrasound in the management of varicose veins. Ann R Coll Surg Engl 1996;78:494-6.
31. Campbell WB, Halim AS, Aertssen A, Ridler BM, Thompson JF, Niblett PG. The place of duplex scanning for varicose veins and common venous problems. Ann R Coll Surg Engl 1996,78:490-3.
32. Salaman R, Fligelstone L, Wright I, Pugh N, Harding K, Lane I. Hand-field Doppler versus colour duplex scanning in the pre-operative assessment of varicose veins. J Vasc Invest 1995; 1:183-6.
33. Darke SG, Vetrivel S, Foy DM, Smith S, Baker S. A comparison of duplex scanning and continuous wave Doppler in the assessment of primary and uncomplicated varicose veins. Eur J Vasc Endovasc Surg 1997;14:457-61.
34. Vasdekis SN, Clarke GH, Nicolaides AN. Quantification of venous reflux by means of duplex scanning. J Vasc Surg 1989;10:670-7.
35. Khaira HS, Parnell A, Crowson MC. Colour flow duplex in the assessment of recurrent varicose veins. Ann R Coll Surg Engl 1996;78:139-41.
36. Sarin S, Sommerville K, Farrah J, Scurr JH, Coleridge Smith PD. Duplex ultrasonography for assessment of venous valvular function of the lower limb. Br J Surg 1994;81:1591-5.
37. Sakurai T, Gupta PC, Matsushita M, Nishikimi N, Nimura Y. Correlation of the anatomical distribution of venous reflux with clinical symptoms and venous haemodynamics in primary varicose veins. Br J Surg 1998;85:213-16.
38. Myers KA, Ziegenbein RW, Zeng GH, Matthews PG. Duplex ultrasonography scanning for chronic venous disease: patterns of venous reflux. J Vasc Sing 1995;21:605-12.
39. Payne SP, London NJ, Jagger C, Newland CJ, Barrie WW, Bell PR. Clinical significance of venous reflux detected by duplex scanning. Br J Surg 1994;81:39-41.
40. DePalma R, Hart M, Zanin L, Massarin H. Physical examination, Doppler ultrasound and colour flow duplex scanning: guides to therapy for primary varicose veins. Phlebology 1993.8:7-11.
41. Singh S, Lees TA, Donlon M, Harris N, Beard JD. Improving the preoperative assessment of varicose veins. Br J Surg 1997;84:801-2.
42. Wills V, Moylan D, Chambers J. The use of routine duplex scanning in the assessment of varicose veins. Aust N Z J Surg 1998;68:41-4.
43. Rautio T, Perala J, Biancari F, Wiik H, Ohtonen P, Haukipuro K, et al. Accuracy of hand-held Doppler in planning the operation for primary varicose veins. Eur J Vasc Endovasc Surg 2002; 24:450-5.
44. Mercer KG, Scott DJ, Berridge DC. Preoperative duplex imaging is required before all operations for primary varicose veins. Br J Surg 1998; 85:1495-7.
45. Smith J, Davies A, Greenhalgh R. Does colour duplex scanning improve the durability of varicose veins surgery. In Greenhalgh R, Powell J, editors. The maintenance and durability of vascular and endovascular procedures. London: WB Saunders; 1999. pp. 231-40.
46. van Rij AM, Jiang P, Solomon C, Christie RA, Hill GB. Recurrence after varicose vein surgery: a prospective long-term clinical study with duplex ultrasound scanning and air plethysmography. J Vasc Surg 2003;38:935-43.
47. Bays RA, Healy DA, Atnip RG, Neumyer M, Thiele BL. Validation of air plethysmography, photoplethysmography, and duplex ultrasonography in the evaluation of severe venous stasis. J Vasc Surg 1994;20:721-7.
48. van Bemmelen PS, Mattos MA, Hodgson KJ, Barkmeier LD, Ramsey DE, Faught WE, et al. Does air plethysmography correlate with duplex scanning in patients with chronic venous insufficiency? J Vasc Surg 1993;18:796-807.
49. Rutgers PH, Kitslaar PJ, Ermers EJ. Photoplethysmography in the diagnosis of superficial venous valvular incompetence. Br J Surg 1993;80:351-3.
50. Welch HJ, Faliakou EC, McLaughlin RL, Umphrey SE, Belkin M, O'Donnell TF Jr. Comparison of descending phlebography with quantitative photoplethysmography, air plethysmography, and duplex quantitative valve closure time in assessing deep venous reflux. J Vasc Surg 1992;16:913-19; discussion 919-20.
51. van Bemmelen PS, van Ramshorst B, Eikelboom BC. Photoplethysmography reexamined: lack of correlation with duplex scanning. Surgery 1992;112:544-8.
52. Weingarten MS, Czeredarczuk M, Scovell S, Branas CC, Mignogna GM, Wolferth CC Jr. A correlation of air plethysmography and color-flow-assisted duplex scanning in the quantification of chronic venous insufficiency. J Vasc Surg 1996; 24:750-4.
53. McMullin GM, Coleridge Smith PD. An evaluation of Doppler ultrasound and photoplethysmography in the investigation of venous insufficiency. Aust N Z J Surg 1992;62:270-5.
54. Baker SR, Burnand KG, Sommerville KM, Thomas ML, Wilson NM, Browse NL. Comparison of venous reflux assessed by duplex scanning and descending phlebography in chronic venous disease. Lancet 1993;341:400-3.
55. Tibbs D. Varicose veins and related disorders. London: Butterworth Heinemann; 1992.
56. Fegan WG. Continuous compression technique of injecting varicose veins. Lancet 1963;2:109-12.
57. Reid RG, Rothnie NG. Treatment of varicose veins by compression sclerotherapy. Br J Surg 1968; 55:889-95.
58. Dejode LR. Injection-compression treatment of varicose veins. A follow-up study. Br J Surg 1970; 57:285-6.
59. Campbell B, Dimson S, Bickerton D. Which treatment would patients prefer for their varicose veins? Ann R Coll Surg Engl 1998;80:212-14.
60. Laurikka J, Sisto T, Salenius J-P, Tarkka M, Auvinen O. Long saphenous vein stripping in the treatment of varicose veins: self- and surgeon-assessed results after 10 years. Phlebology 1994; 9:13-16.
61. Larson RH, Lofgren EP, Myers TT, Lofgren KA. Long-term results after vein surgery. Study of 1,000 cases after 10 years. Mayo Clin Proc 1974; 49:114-17.
62. Hobbs JT. Surgery and sclerotherapy in the treatment of varicose veins. A random trial. Arch Surg 1974;109:793-6.
63. Jakobsen BH. The value of different forms of treatment for varicose veins. Br J Surg 1979; 66:182-4.
64. Einarsson E, Eklof B, Neglen P. Sclerotherapy or surgery as treatment for varicose veins: a prospective randomized study. Phlebology 1993; 8:22-6.
65. Perrin MR, Guex JJ, Ruckley CV, dePalma RG, Royle JP, Eklof B, et al. Recurrent varices after surgery (REVAS), a consensus document. REVAS Group. Cardiovasc Surg 2000;8:233-45.
66. Lurie F, Creton D, Eklof B, Kabnick LS, Kistner RL, Pichot O, et al. Prospective randomized study of endovenous radiofrequency obliteration (closure procedure) versus ligation and stripping in a selected patient population (EVOLVeS Study). J Vasc Surg 2003;38:207-14.
67. Merchant RF, DePalma RG, Kabnick LS. Endovascular obliteration of saphenous reflux: a multicenter study. J Vasc Surg 2002;35:1190-6.
68. Fassiadis N, Kianifard B, Holdstock JM, Whiteley MS. A novel approach to the treatment of recurrent varicose veins. Int Angiol 2002; 21:275-6.
69. Chang CJ, Chua JJ. Endovenous laser photocoagulation (EVLP) for varicose veins. Lasers Surg Med 2002;31:257-62.
70. Min RJ, Khilnani N, Zimmet SE. Endovenous laser treatment of saphenous vein reflux: long-term results. J Vasc Interv Radiol 2003;14:991-6.
71. Cabrera J, Cabrera J, Jr., Garcia-Olmedo MA. Sclerosants in microfoam. A new approach in angiology. Int Angiol 2001;20:322-9.
72. Frullini A, Cavezzi A. Sclerosing foam in the treatment of varicose veins and telangiectases: history and analysis of safety and complications. Dermatol Surg 2002;28:11-15.
73. Belcaro G, Cesarone MR, Di Renzo A, Brandolini R, Coen L, Acerbi G, et al. Foamsclerotherapy, surgery, sclerotherapy, and combined treatment for varicose veins: a 10-year, prospective, randomized, controlled, trial (VEDICO trial). Angiology 2003;54:307-15.
74. Campbell B. New treatments for varicose veins. BMJ 2002;324:689-90.
75. Harris EJ. Radiofrequency ablation of the long saphenous vein without high ligation versus high ligation and stripping for primary varicose veins: pros and cons. Semin Vasc Surg 2002;15:34-8.
76. Rautio T, Ohinmaa A, Perala J, Ohtonen P, Heikkinen T, Wiik H, et al. Endovenous obliteration versus conventional stripping operation in the treatment of primary varicose veins: a randomized controlled trial with comparison of the costs. J Vasc Surg 2002; 35:958-65.
77. Mylankal K, Hughes H, Subremanian P, Spark I, Benveuiste G, Fitridge R, et al. A randomised controlled trial to compare hook phlebectomy with transilluminated powered phlebectomy. Br J Surg 2004;91:1078(abstract).
78. Bjerle P, Gjores JE, Thulesius O, Berlin E. Treatment of venous insufficiency with dihydroergotamine. Vasa 1979;8:158-62.
79. Roeckaerts E, Vanden Bussche G. Double-blind placebo-controlled studies with flunarizine in venous insufficiency. Angiology 1980;31:833-45.
80. Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 1996; 347:292-4.
81. Pittler MH, Ernst E. Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review. Arch Dermatol 1998;134:1356-60.
82. Mancini S, Jr., Piccinetti A, Nappi G, Mancini S, Caniato A, Coccheri S. Clinical, functional and quality of life changes after balneokinesis with sulphurous water in patients with varicose veins. Vasa 2003;32:26-30.
83. Coon WW, Willis PW, III, Keller JB. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation 1973;48:839-46.
84. Guberan E, Widmer LK, Glaus L, Muller R, Rougemont A, Da Silva A, et al. Causative factors of varicose veins: myths and facts. An epidemiological study of 610 women. Vasa 1973; 2:115-20.
85. Widmer LK, Stahelin HB. Peripheral venous disorders. Berne: Hans Huber; 1978. pp. 1-90.
86. Abramson JH, Hopp C, Epstein LM. The epidemiology of varicose veins. A survey in western Jerusalem. J Epidemiol Commun Health 1981;35:213-17.
87. Novo S, Avellone G, Pinto A, Davy G, D'Eredita F, Riolo F, et al. Presence of primitive varicose veins in randomised population sample in western Sicily. Int Angiol 1988;7:176-81.
88. Leipnitz G, Kiesewetter P, Waldhausen P, Jung F, Witt R, Wenzel E. Prevalence of venous disease in the population: first results from a prospective study carried out in greater Aachen. In Davy A, Stemmer R, editors. Phlebology '89. Paris: John Libbey Eurotext; 1989. pp. 169-71.
89. Hirai M, Naiki K, Nakayama R. Prevalence and risk factors of varicose veins in Japanese women. Angiology 1990;41:228-32.
90. Komsuoglu B, Goldeli O, Kulan K, Cetinarslan B, Komsuoglu SS. Prevalence and risk factors of varicose veins in an elderly population. Gerontology 1994;40:25-31.
91. Sisto T, Reunanen A, Laurikka J, Impivaara O, Heliovaara M, Knekt P, et al. Prevalence and risk factors of varicose veins in lower extremities: mini-Finland health survey. Eur J Surg 1995; 161:405-14.
92. Criqui MH, Jamosmos M, Fronek A, Denenberg JO, Langer RD, Bergan J, et al. Chronic venous disease in an ethnically diverse population: the San Diego Population Study. Am J Epidemiol 2003;158:448-56.
93. Malhotra SL. An epidemiological study of varicose veins in Indian railroad workers from the South and North of India, with special reference to the causation and prevention of varicose veins. Int J Epidemiol 1972;1:177-83.
94. Beaglehole R. Varicose veins in the South Pacific. Int J Epidemiol 1975;4:295-9.
95. Stanhope JM. Varicose veins in a population of lowland New Guinea. Int J Epidemiol 1975; 4:221-5.
96. Richardson JB, Dixon M. Varicose veins in tropical Africa. Lancet 1977;i:791-2.
97. Maffei FH, Magaldi C, Pinho SZ, Lastoria S, Pinho W, Yoshida WB, et al. Varicose veins and chronic venous insufficiency in Brazil: prevalence among 1755 inhabitants of a country town. Int J Epidemiol 1986;15:210-17.
98. Laurikka J, Sisto T, Auvinen O, Tarkka M, Laara E, Hakama M. Varicose veins in a Finnish population aged 40-60. J Epidemiol Commun Health 1993;47:355-7.
99. Schultz-Ehrenburg U, Weindorf N, Matthes U, Hirche H. An epidemiologic study of the pathogenesis of varices. The Bochum study I-III. Phlebologie 1992;45:497-500 (in German).
100. Lee AJ, Evans CJ, Allan PL, Ruckley CV, Fowkes FG. Lifestyle factors and the risk of varicose veins: Edinburgh Vein Study. J Clin Epidemiol 2003;56:171-9.
101. Mekky S, Schilling RS, Walford J. Varicose veins in women cotton workers. An epidemiological study in England and Egypt. BMJ 1969;ii:591-5.
102. Lorenzi G, Bavera P, Cipolat L, Carlesi R. The prevalence of primary varicose veins among workers of a metal and steel factory. In Negus J, Jantet J, editors. Phlebology '85. Paris: John Libbey; 1986. pp. 18-21.
103. Tisi PV, Beverley CA. Injection sclerotherapy for varicose veins (Cochrane Review). Cochrane Database Syst Rev 2003(4):CDO01732.
104. Rigby K, Palfreyman S, Beverley C, Michaels J. Surgery versus sclerotherapy for the treatment of varicose veins. Cochrane Database Syst Rev 2004(4): CD004980.
105. Rigby KA, Palfreyman SJ, Beverley C, Michaels JA. Surgery for varicose veins: use of tourniquet. Cochrane Database Syst Rev 2002(4):CD001486.
106. Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DE. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999;354:1896-900.
107. Hobbs JT. The treatment of varicose veins. A random trial of injection - compression therapy versus surgery. Br J Surg 1968;55:777-80.
108. Chant AD, Jones HO, Weddell JM. Varicose veins: a comparison of surgery and injection - compression sclerotherapy. Lancet 1972; ii: 1188-91.
109. Beresford SA, Chant AD, Jones HO, Piachaud D, Weddell JM. Varicose veins: a comparison of surgery and infection/compression sclerotherapy. Five-year follow-up. Lancet 1978;i:921-4.
110. Doran FSA, White MA, White M. A clinical trial designed to discover if the primary treatment of varicose veins should be by Fegan's method or by an operation. Br J Surg 1975;62:72-6.
111. Rutgers PH, Kitslaar PJ. Randomized trial of stripping versus high ligation combined with sclerotherapy in the treatment of the incompetent greater saphenous vein. Am J Surg 1994; 168:311-15.
112. Belcaro G, Dugall M, Vasdekis S, Christopoulos D, Laurora G, Nicolaides AN, et al. Comparison between endovascular sclerotherapy, surgery and surgery plus sclerotherapy in the treatment of superficial vein insufficiency. a randomized study on 10 years follow-up. Angeiologie 1998;50:57-61.
113. Belcaro G, Nicolaides AN, Ricci A, Dugall M, Errichi BM, Vasdekis SN. Endovascular sclerotherapy, surgery, and surgery plus sclerotherapy in superficial venous incompetence: a randomized, 10-year follow-up trial - final results. Angiology 2000;51:529-34.
114. Schulz KF. Randomised trials, human nature and reporting guidelines. Lancet 1996;348:596-8.
115. Woodyer AB, Dormandy JA. Is it necessary to strip the long saphenous vein? Phlebology 1986;1:221-4.
116. Sarin S, Scurr JH, Coleridge Smith PD. Assessment of stripping the long saphenous vein in the treatment of primary varicose veins. Br J Surg 1992;79:889-93.
117. Sarin S, Scurr JH, Coleridge Smith PD. Stripping of the long saphenous vein in the treatment of primary varicose veins. Br J Surg 1994;81:1455-8.
118. Jones L, Braithwaite BD, Selwyn D, Cooke S, Earnshaw JJ. Neovascularisation is the principal cause of varicose vein recurrence: results of a randomised trial of stripping the long saphenous vein. Eur J Vasc Endovasc Surg 1996;12:442-5.
119. Dwerryhouse S, Davies B, Harradine K, Earnshaw JJ. Stripping the long saphenous vein reduces the rate of reoperation for recurrent varicose veins: five-year results of a randomized trial. J Vasc Surg 1999;29:589-92.
120. Sarin S, Scurr JH, Coleridge-Smith PD. Treatment of primary varicose veins: comparison of saphenofemoral ligation with and without above-knee long saphenous vein stripping. J Vasc Surg 1992;15(Abstracts):452.
121. Sarin S, Coleridge Smith PD, Scurr JH. Comparison of saphenofemoral ligation with and without long saphenous vein stripping. Br J Surg 1992;79:464.
122. Munn SR, Morton JB, Macbeth WA, Mcleish AR. To strip or not to strip the long saphenous vein? A varicose veins trial. Br J Surg 1981;68:426-8.
123. Hammarsten J, Pedersen P, Cederlund CG, Campanello M. Long saphenous vein saving surgery for varicose veins. A long-term follow-up. Eur J Vasc Surg 1990;4:361-4.
124. Campanello M, Hammarsten J, Forsberg C, Bernland P, Henrikson O, Jensen J. Standard stripping versus long saphenous vein-saving surgery for primary varicose veins: a prospective, randomized study with the patients as their own controls. Phlebology 1996;11:45-9.
125. Corbett CRR, Harries WJ. Which vein stripper, metal or plastic disposable? Phlebology 1991; 6:149-51.
126. Khan B, Khan S, Greaney MG, Blair SD. Prospective randomized trial comparing sequential avulsion with stripping of the long saphenous vein. Br J Surg 1996;83:1559-62.
127. Cox SJ, Wellwood JM, Martin A. Saphenous nerve injury caused by stripping of the long saphenous vein. BMJ 1974;i:415-17.
128. Ramasastry SS, Dick GO, Futrell JW. Anatomy of the saphenous nerve: relevance to saphenous vein stripping. Am Surg 1987;53:274-7.
129. Docherty JG, Morrice JJ, Bell G. Saphenous neuritis following varicose vein surgery. Br J Surg 1994;81:698.
130. Tyrrell MR, Rocker M, Maisey N, Marshall R, Taylor PR, Negus D. A randomised trial to compare standard and invagination stripping of long saphenous vein in the thigh. Phlebology 1995;10:451-53.
131. Butler C, Coleridge-Smith PD, Scurr JH. Inverting stripping versus conventional stripping of the long saphenous vein. Phlebology 1995;10:128.
132. Wilson S, Pryke S, Scott R, Walsh M, Barker SGE. 'Inversion' stripping of the long saphenous vein. Phlebology 1997;12:91-5.
133. Lacroix H, Nevelsteen A, Suy R. Invaginating versus classic stripping of the long saphenous vein: a randomized prospective study. Acta Chir Belg 1999;99:22-5.
134. Kent PJ, Maughan J, Burniston M, Nicholas T, Parkin A, Robinson PJ. Perforation-invagination (PIN) stripping of the long saphenous vein reduces thigh haematoma formation in varicose vein surgery. Phlebology 1999;14:43-7.
135. Durkin MT, Turton EPL, Scott DJA, Berridge DC. A prospective randomised trial of PIN versus conventional stripping in varicose vein surgery. Ann R Coll Surg Engl 1999;81:171-4.
136. Durkin MT, Turton EP, Berridge DC. Long saphenous vein stripping and quality of life - randomised trial. Eur J Vasc Endovasc Surg 2001;21:545-9.
137. Holme K, Matzen M, Bomberg AJ, Outzen SL, Holme JB. Partial or total stripping of the great saphenous vein. 5-year recurrence frequency and 3-year frequency of neural complications after partial and total stripping of the great saphenous vein. Ugeskr Laeger 1996;158:405-8 (in Danish).
138. Holme JB, Skajaa K, Holme K. Incidence of lesions of the saphenous nerve after partial or complete stripping of the long saphenous vein. Acta Chir Scand 1990;156:145-8.
139. Altman DG. Better reporting of randomised controlled trials: the CONSORT statement. BMJ 1996;313:570-1.
140. Wakankar HM, Nicholl JE, Koka R, D'Arcy JC. The tourniquet in total knee arthroplasty. A prospective, randomised study. J Bone Joint Surg 1999;81:30-3.
141. Kumar SN, Chapman JA, Rawlins I, Kumar SN. Vascular injuries in total knee arthroplasty: a review of the problem with special reference to the possible effects of the tourniquet. J Arthroplasty 1998;13:211-16.
142. Yagiz A, Ozdemir O, Aksit R. Tourniquet paralysis after primary nerve repair. Am J Phys Med Rehabil 2000;79:298-300.
143. Farrands PA, Royle G, Namaldin A, Webster JHH. Varicose vein surgery: effect of tourniquet on intra-operative blood loss and post-operative cosmesis. Br J Surg 1987;74:330.
144. Robinson J, Macierewicz J, Beard J. Using the Boazul cuff to reduce blood loss in varicose vein surgery. Eur J Vasc Endovasc Surg 2000;20:390-3.
145. Sykes TCF, Brookes P, Hickey NC. A prospective randomised trial of tourniquet in varicose vein surgery. Ann R Coll Surg Engl 2000;82:280-2.
146. Rhys-Davies RC, Stotter AT. The Rhys-Davies exsanguinator. Ann R Coll Surg Engl 1985;67:193-5.
147. Hickey NC. Prospective randomised trial of varicose vein surgery with or without tourniquet. In National Trials Register 1998: http://www.nrr.nhs.uk/viewdocument.asp?ID=N0282000633.
148. Fisher R. Results of the bloodless limb technique in varicose veins surgery. Phlebologie 1994;23:1-6.
149. Klenerman L, Chakrabarti R, Mackie I, Brozovic M, Stirling Y. Changes in haemostatic system after application of a tourniquet. Changes in haemostatic system after application of a tourniquet. Lancet 1977;i:970-2.
150. Lahl WA, Albrecht HG. Optimizing of varicose vein surgery by employment of a roll-on tourniquet. Phlebologie 2000;29:134-6.
151. Lofqvist J. Surgery in the bloodless field with cuffs. Chirurg 1988;59:853-84.
152. Meyer T, Weber H, Lang W. Use of a tourniquet in varicose vein surgery. Advantages of conventional technique with a standard cuff. Vasomed 1997; 9:69-71.
153. Mildner AH, Hilbe G. Bleeding complications in varicose vein surgery: Relationship with perioperative thromboprophylaxis with LMWH as well as operating in a bloodless field using a tourniquet. Phlebologie 2000;29:163-6.
154. Royle JP. Operative management of varicose veins. Hosp Update 1984;10:941-9.
155. Streichenberger R, Barjoud H, Konieczny M, Elias W. Surgical management of major varicose veins of the lower limb using a pneumatic tourniquet. Ann Vasc Surg 1991;5:559-60.
156. Fischer R. A new generation in varicose vein surgery? Vasa 1991;20:311-18.
157. Wigger P. Surgical treatment of primary varicose veins. Schweiz Med Wochenschr 1998;128:1781-8.
158. Sachs G, Thiele H, Gai H. Initial experience with endoscopic subfascial dissection of perforating veins in 100 interventions. Zentralbe Chir 1994; 119:501-5.
159. Tsavellas GRC. Tourniquet use during varicose vein surgery: a survey of current practice among Wessex surgeons. Tourniquet use during varicose vein surgery: a survey of current practice among Wessex surgeons. Ann R Coll Surg Engl 2000;82:116-19.
160. Corbett R, Jayakumar KN. Clean up varicose vein surgery - use a tourniquet. Ann R Coll Surg Engl 1989;71:57-8.
161. Thompson JE, Royle GT, Farrands PA, Najmaldin A, Clifford PC, Webster JH, et al. Varicose vein surgery using a pneumatic tourniquet: reduced blood loss and improved cosmesis. Ann R Coll Surg Engl 1990;72:119-21; discussion 122.
162. Abramowitz I. The treatment of varicose veins in pregnancy by empty vein compressive sclerotherapy. S Afr Med J 1973,47:607-10.
163. Schmidt CGR, Perez P, Schmitt J. Double blind plethysmographic study of venous effects of heptaminol adenosine phosphate (HAP) in patients with primary varicose veins. Eur J Clin Pharmacol 1989;37:37-40.
164. Androulakis GPP. Plethysmographic confirmation of the beneficial effects of calcium dobesilate in primary varicose veins. Angiology 1989;40:1-4.
165. Anderson JH, Geraghty JG, Wilson YT, Murray GD, McArdle CS, Anderson JR. Paroven and graduated compression hosiery for superficial venous insufficiency. Phlebolaggy 1990;5:271-6.
166. Ernst E, Saradeth T, Resch KL. Complementary treatment of varicose veins - a randomised, placebo controlled double-blind trial. Phlebology 1990;5:157-63.
167. Ernst E, Saradeth T, Resch KL. A single blind randomized, controlled trial of hydrotherapy for varicose-veins. Vasa 1991;20:147-52.
168. Schuller-Petrovic S, Wolzt M, Bohler K, Jima B, Eichler HG. Studies on the effect of short-term oral dihydroergotamine and troxerutin in patients with varicose veins. Clin Pharmacol Ther 1994; 56:452-9.
169. Ernst E, Saradeth T, Resch KL. Hydrotherapy for varicose-veins - a randomized, controlled trial. Phlebology 1992;7:154-7.
170. Saradeth T, Resch KL, Ernst E. Hydrotherapy for varicose veins - a single blind, controlled trial. Perfusion 1991;4:1-2.
171. Fink A, Kosecoff J, Chassin M, Brook RH. Consensus methods: characteristics and guidelines for use. Am J Pub Health 1984;74:979-83.
172. Madar G, Widmer L, Zemp E, Maggs M. Varicose veins and chronic venous insufficiency disorder or disease. Vasa 1986;15:126-34.
173. Porter JM, Moneta GL. Reporting standards in venous disease: an update. International Consensus Committee on Chronic Venous Disease. J Vasc Surg 1995;21:635-45.
174. Hosoi Y, Yasuhara H, Shigematsu H, Aramoto H, Komiyama T, Muto T. A new method for the assessment of venous insufficiency in primary varicose veins using near-infrared spectroscopy. J Vasc Surg 1997;26:53-60.
175. Sytchev GG. Classification of chronic venous disorders of lower extremities and pelvis. Int Angiol 1985;4:203-6.
176. Somerville J, Byrne P, King D. Turbulence in the classification of varicose veins. Br J Surg 1973; 60:311-12.
177. Fukuoka M, Okada M, Sugimoto T. Foot venous pressure measurement for evaluation of lower limb venous insufficiency. J Vasc Surg 1998;27:671-6.
178. Stonebridge PA, Chalmers N, Beggs I, Bradbury AW, Ruckley CV. Recurrent varicose veins: a varicographic analysis leading to a new practical classification. Br J Surg 1995;82:60-2.
179. Weiss R, Weiss M. Painful telangiectasias, diagnosis and treatment. In Bergan J, Goldman M, editors. Varicose veins and telangiectasias, diagnosis and treatment. St Louis, MO: Quality Medical Publishing; 1993. pp. 390.
180. Brazier J, Usherwood T, Harper R, Thomas K. Deriving a preference-based single index from the UK SF-36 health survey. J Clin Epidemiol 1998; 51:1115-28.
181. Brooks R. EuroQol: the current state of play. Health Policy 1996;37:53-72.
182. The EuroQol Group. EuroQol - a new facility for the measurement of health related quality of life. Health Policy 1990;16:199-208.
183. Dolan P. Modeling valuations for EuroQol health states. Med Care 1997;35:1095-108.
184. HM Treasury. The green book. Appraisal and evaluation in central government. London: HMSO; 2003.
185. Netten A, Rees T, Glenys H. Unit costs of health and social care. Canterbury: Personal Social Services Research Unit, University of Kent; 2001.
186. NHS Executive. NHS reference costs. London: HMSO; 2003.
187. British Medical Association. British National formulary. London: BMA, 2002.
188. Brazier J, Roberts J, Deverill M. The estimation of a preference-based measure of health from the SF-36. J Health Econ 2002;21:271-92.
189. Thompson SG, Barber JA. How should cost data in pragmatic randomised trials be analysed? BMJ 2000;320:1197-200.
190. Glick H, Briggs A, Polsky D. Quantifying stochastic uncertainty and presenting results of cost effectiveness analyses. Expert Rev Pharmacoecon Outcomes Res 2001;1:25-36.
191. Ryan M, Scott DA, Reeves C, Bate A, van Teijlingen ER, Russell EM, et al. Eliciting public preferences for healthcare: a systematic review of techniques. Health Technol Assess 2001;5(5).
192. Ryan M, Ratcliffe J, Tucker J. Using willingness to pay to value alternative models of antenatal care. Soc Sci Med 1997;44:371-80.
193. Dixon S, Shackley P. Estimating the benefits of community water fluoridation using the willingness-to-pay technique: results of a pilot study. Commun Dent Oral Epidemiol 1999;27:124-9.
194. Lundberg L, Johannesson M, Silverdahl M, Hermansson C, Lindberg M. Quality of life, health-state utilities and willingness to pay in patients with psoriasis and atopic eczema. Br J Dermatol 1999;141:1067-75.
195. Donaldson C, Shackley P, Abdalla M. Using willingness to pay to value close substitutes: carrier screening for cystic fibrosis revisited. Health Econ 1997;6:145-59.
196. Johannesson M, Fagerberg B. A health-economic comparison of diet and drug treatment in obese men with mild hypertension. J Hypertens 1992; 10:1063-70.
197. Critchley G, Handa A, Maw A, Harvey A, Harvey MR, Corbett CR. Complications of varicose vein surgery. Ann R Coll Surg Engl 1997;79:105-10.
198. Morrell CJ, Walters SJ, Dixon S, Collins KA, Brereton LM, Peters J, et al. Cost effectiveness of community leg ulcer clinics: randomised controlled trial. BMJ 1998;316:1487-91.
199. Office for National Statistics. Deaths 2001: rates per 1000 population by age-group and sex. London: Department of Health, URL: www.statistics.gov.uk. Accessed 2003.
200. Harvard School of Public Health. Catalogue of rreference scores. URL: http://www.hcra.harvard.edu/pdf/preferencescores.pdf. Accessed 2003.
201. Department of Health. NHS reference costs 2003 and national tariff 2004 ('payment by results core tools 2004'). London: HMSO; 2004.
202. von Neuman J, Morgenstern O. Theory of games and economic behavior. Princeton, CT: Princeton University Press; 1944.
203. Torrance GW. Measurement of health state utilities for economic appraisal. J Health Econ 1986;5:1-30.
204. Torrance GW, Thomas WH, Sackett DL. A utility maximization model for evaluation of health care programs. Health Serv Res 1972;7:118-33.
205. Lenert LA, Treadwell JR, Schwartz CE. Associations between health status and utilities implications for policy. Med Care 1999;37:479-89.
206. Grunberg SM, Srivastava A, Grunberg KJ, Weeks J. Intensity of chemotherapy-induced emesis and overall survival as determinants of a global utility score. Support Care Cancer 2002;10:624-9.
207. Spencer A. The implications of linking questions within the SG and TTO methods. Health Econ 2004;13:807-18.
208. NICE. Completed technology appraisals 2000/2001. Report from the Chairman to the Annual General Meeting (July 2001). London: National Institute of Clinical Excellence; 2001.
209. Gyldmark M, Morrison GC. Demand for health care in Denmark: results of a national sample survey using contingent valuation. Soc Sci Med 2001;53:1023-36.
210. Garside R, Stein K, Wyatt K, Round A, Price A. The effectiveness and cost-effectiveness of microwave and thermal balloon endometrial ablation for heavy menstrual bleeding: a systematic review and economic modelling. Health Technol Assess 2004;8(3).
211. Turner D, Wailoo A, Nicholson K, Cooper N, Sutton A, Abrams K. Systematic review and economic decision modelling for the prevention and treatment of influenza A and B. Health Technol Assess 2003;7(35).
212. Chilcott J, Brennan A, Booth A, Karnon J, Tappenden P. The role of modelling in prioritising and planning clinical trials. Health Technol Assess 2003;7(23).
213. NICE. Guide to the methods of technology appraisal. London: National Institute for Clinical Excellence. URL: http://www.nice.org.uk. Accessed 2004.
214. Rawlins MD, Culyer AJ. National Institute for Clinical Excellence and its value judgments. BMJ 2004;329:224-7.
215. Brazier J, Jones N, Kind P. Testing the validity of the EuroQol and comparing it with the SF-36 health survey questionnaire. Qual Life Res 1993; 2:169-80.
216. Torrance GW, Feeny DH, Furlong WJ, Barr RD, Zhang Y, Wang Q. Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care 1996;34:702-22.
217. Badia X, Roset M, Herdman M. Inconsistent responses in three preference-elicitation methods for health states. Soc Sci Med 1999;49:943-50.
218. Swan JS, Sainfort F, Lawrence WF, Kuruchittham V, Kongnakorn T, Heisey DM. Process utility for imaging in cerebrovascular disease. Acad Radiol 2003;10:266-74.
219. Donaldson C, Shackley P. Does 'process utility' exist? A case study of willingness to pay for laparoscopic cholecystectomy. Soc Sci Med 1997; 44:699-707.
220. Michaels JA, Campbell WB and Rigby KA. A new pragmatic classification system for varicose veins. Phlebology 2001;16:29-33.