Non-mechanical inflammatory causes of back pain: Current concepts

Skeletal Radiology

Volumn 35, Issue 7, 2006, Pages 485-487

  Ross, Jeffrey S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; ETANERCEPT; INFLIXIMAB; MATRIX METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACKACHE; CLINICAL TRIAL; DRUG DOSE REGIMEN; DRUG INFUSION; ENZYME ACTIVITY; HUMAN; IMMUNOPHENOTYPING; INTERVERTEBRAL DISK HERNIA; MACROPHAGE FUNCTION; NEOVASCULARIZATION (PATHOLOGY); NERVE CELL; NERVE COMPRESSION; NERVE INJURY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SCIATIC NERVE; SPINAL NERVE;

HUMANS; INFLAMMATION; LOW BACK PAIN; SPINAL DISEASES;

EID: 33744804581     PISSN: 03642348     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00256-006-0121-5     Document Type: Article

References (26)

1. Mixter W, Barr JS. Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med 1934;211
2. Kayama S, Konno S, Olmarker K, Yabuki S, Kikuchi S. Incision of the anulus fibrosus induces nerve root morphologic, vascular, and functional changes. An experimental study. Spine 1996;21:2539-2543
3. Olmarker K, Nordborg C, Larsson K, Rydevik B. Ultrastructural changes in spinal nerve roots induced by autologous nucleus pulposus. Spine 1996;21:411-414
4. Olmarker K, Blomquist J, Stromberg J, Nannmark U, Thomsen P, Rydevik B. Inflammatogenic properties of nucleus pulposus. Spine 1995;20:665-669
5. Kawaguchi S, Yamashita T, Yokogushi K, Murakami T, Ohwada O, Sato N. Immunophenotypic analysis of the inflammatory infiltrates in herniated intervertebral discs. Spine 2001;26:1209-1214
6. Doita M, Kanatani T, Harada T, Mizuno K. Immunohistologic study of the ruptured intervertebral disc of the lumbar spine. Spine 1996;21:235-241
7. Benoist M. The natural history of lumbar disc herniation and radiculopathy. Jt Bone Spine 2002;69:155-160
8. Ito T, Yamada M, Ikuta F, et al. Histologic evidence of absorption of sequestration-type herniated disc. Spine 1996;21:230-234
9. Virri J, Gronblad M, Savikko J, et al. Prevalence, morphology, and topography of blood vessels in herniated disc tissue. A comparative immunocytochemical study. Spine 1996;21:1856-1863
10. Gronblad M, Virri J, Tolonen J, et al. A controlled immunohistochemical study of inflammatory cells in disc herniation tissue. Spine 1994;19:2744-2751
11. Igarashi T, Kikuchi S, Shubayev V, Myers RR. 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 2000;25:2975-2980
12. Weiler C, Nerlich AG, Bachmeier BE, Boos N. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls. Spine 2005;30:44-53
13. Olmarker K, Rydevik B. Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: Possible implications for future pharmacologic treatment strategies of sciatica. Spine 2001;26:863-869
14. Genevay S, Stingelin S, Gabay C. Efficacy of etanercept in the treatment of acute, severe sciatica: A pilot study. Ann Rheum Dis 2004;63:1120-1123
15. Karppinen J, Korhonen T, Malmivaara A, et al. Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica. Spine 2003;28:750-753
16. Korhonen T, Karppinen J, Malmivaara A, et al. Efficacy of infliximab for disc herniation-induced sciatica: One-year follow-up. Spine 2004;29:2115-2119
17. Takahashi H, Suguro T, Okazima Y, Motegi M, Okada Y, Kakiuchi T. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21:218-224
18. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM. Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc. Spine 2002;27:1402-1407
19. Burke JG, RW GW, Conhyea D, et al. Human nucleus pulposis can respond to a pro-inflammatory stimulus. Spine 2003;28:2685-2693
20. Roberts S, Evans H, Menage J, et al. TNFalpha-stimulated gene product (TSG-6) and its binding protein, IalphaI, in the human intervertebral disc: New molecules for the disc. Eur Spine J 2005;14:36-42
21. Grang L, Gaudin P, Trocme C, Phelip X, Morel F, Juvin R. Intervertebral disk degeneration and herniation: The role of metalloproteinases and cytokines. Jt Bone Spine 2001;68:547-553
22. Liu J, Roughley PJ, Mort JS. Identification of human intervertebral disc stromelysin and its involvement in matrix degradation. J Orthop Res 1991;9:568-575
23. Haro H, Kato T, Komori H, Osada M, Shinomiya K. Vascular endothelial growth factor (VEGF)-induced angiogenesis in herniated disc resorption. J Orthop Res 2002;20:409-415
24. Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O'Brien J, Jayson MI. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997;Jul 19 (350):178-181
25. Freemont AJ, Watkins A, Le MC, et al. Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol 2002;197:286-292
26. Franson RC, Saal JS, Saal JA. Human disc phospholipase A2 is inflammatory. Spine 1992;17:S129-S132