Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization

Learning and Memory

Volumn 13, Issue 3, 2006, Pages 397-403

  Hawkins, Robert D ^a,b   Cohen, Tracey E ^a   Kandel, Eric R ^a,b,c  

^a Howard Hughes Medical Institute   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APLYSIA; ARTICLE; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SENSORY NERVE CELL; STIMULUS; TOUCH;

ANIMALS; APLYSIA; ASSOCIATION LEARNING; BEHAVIOR, ANIMAL; ELECTRIC STIMULATION; HABITUATION, PSYCHOPHYSIOLOGIC;

EID: 33744803985     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.49706     Document Type: Article

References (33)

1. Antonov, I., Kandel, E.R., and Hawkins, R.D. 1999. The contribution of facilitation of monosynaptic PSPs to dishabituation and sensitization of the Aplysia siphon withdrawal reflex. J. Neurosci. 19: 10438-10450.
2. _. 2005. Roles of PKA, PKC, and CamKII in dishabituation and sensitization of the Aplysia siphon-withdrawal reflex. Abstract Viewer/Itinerary Planner, Program No. 540.6. Society for Neuroscience, Washington, DC.
3. Byrne, J.H. and Kandel, E.R. 1996. Presynaptic facilitation revisited: State and time dependence. J. Neurosci. 16: 425-435.
4. Carew, T.J., Castellucci, V.F., and Kandel, E.R. 1971. An analysis of dishabituation and sensitization of the gill-withdrawal reflex in Aplysia. Int. J. Neurosci. 2: 79-98.
5. Cohen, T.E., Kaplan, S.W., Kandel, E.R., and Hawkins, R.D. 1997. A simplified preparation for relating cellular events to behavior: Mechanisms contributing to habituation, dishabituation, and sensitization of the Aplysia gill-withdrawal reflex. J. Neurosci. 17: 2886-2899.
6. Ehrlich, J.S., Boulis, N.M., Karrer, T., and Sahley, C.L. 1992. Differential effects of serotonin depletion on sensitization and dishabituation in the leech, Hirudo medicinalis. J. Neurobiol. 23: 270-279.
7. Frost, L., Kaplan, S.W., Cohen, T.E., Henzi, V., Kandel, E.R., and Hawkins, R.D. 1997. A simplified preparation for relating cellular events to behavior: Contribution of LE and unidentified siphon sensory neurons to mediation and habituation of the Aplysia gill- and siphon withdrawal reflex. J. Neurosci. 17: 2900-2913.
8. Ghirardi, M., Braha, O., Hochner, B., Montarolo, P.G., Kandel, E.R., and Dale, N. 1992. Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons. Neuron 9: 479-489.
9. Gingrich, K.J. and Byrne, J.H. 1985. Simulation of synaptic depression, post-tetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating gill-withdrawal reflex in Aplysia. J. Neurophysiol. 53: 652-659.
10. Glanzman, D.L., Mackey, S.L., Hawkins, R.D., Dyke, A., Lloyd, P.E., and Kandel, E.R. 1989. Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock. J. Neurosci. 9: 4200-4213.
11. Grether, W.F. 1938. Pseudo-conditioning without paired stimulation encountered in attempting backward conditioning. J. Comp. Psychol. 25: 91-96.
12. Groves, P.M. and Thompson, R.F. 1970. Habituation: A dual-process theory. Psychol. Rev. 77: 419-450.
13. Hawkins, R.D. 1989. A biologically based computational model for several simple forms of learning. Psychol. Learn. Motiv. 23: 65-108.
14. Hawkins, R.D., Cohen, T.E., Greene, W., and Kandel, E.R. 1998. Relationships between dishabituation, sensitization, and inhibition of the gill- and siphon-withdrawal reflex in Aplysia: Effects of response measure, test time, and training stimulus. Behav. Neurosci. 112: 24-38.
15. Hochner, B., Klein, M., Schacher, S., and Kandel, E.R. 1986. Additional component in cellular mechanism of presynaptic facilitation contributes to behavioral dishabituation in Aplysia. Proc. Natl. Acad. Sci. 83: 8794-8798.
16. Huang, Y.Y. and Kandel, E.R. 1998. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron 21: 169-178.
17. Huang, Y.Y., Li, X.C., and Kandel, E.R. 1994. cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell 79: 69-79.
18. Jensen, V., Kaiser, K.M., Borchardt, T., Adelmann, G., Rozov, A., Burnashev, N., Brix, C., Frotscher, M., Andersen, P., Hvalby, O., et al. 2003. A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A. J. Physiol. 553: 843-856.
19. Jin, I. and Hawkins, R.D. 2003. Presynaptic and postsynaptic mechanisms of a novel form of homosynaptic potentiation at Aplysia sensory-motor neuron synapses. J. Neurosci. 23: 7288-7297.
20. Kupfermann, I., Castellucci, V., Pinsker, H., and Kandel, E.R. 1970. Neuronal correlates of habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science 167: 1743-1745.
21. Lev-Ram, V., Wong, S.T., Storm, D.R., and Tsien, R.Y. 2002. A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proc. Natl. Acad. Sci. 99: 8389-8393.
22. 2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy. J. Neurosci. 25: 5623-5637.
23. Mackey, S.L., Glanzman, D.L., Small, S.A., Dyke, A.M., Kandel, E.R., and Hawkins, R.D. 1987. Tail shock produces inhibition as well as sensitization of the siphon-withdrawal reflex of Aplysia: Possible behavioral role for presynaptic inhibition mediated by the peptide Phe-Met-Arg-Phe-NH2. Proc. Natl. Acad. Sci. 84: 8730-8734.
24. Marcus, E.A., Nolen, T.G., Rankin, C.H., and Carew, T.J. 1988. Behavioral dissociation of dishabituation, sensitization, and inhibition in Aplysia. Science 241: 210-213.
25. Pavlov, I.P. 1927. Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex. (trans. G.V. Anrep). Oxford University Press, London.
26. Pinsker, H., Kupfermann, I., Castellucci, V., and Kandel, E.R. 1970. Habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science 167: 1740-1742.
27. Sahley, C.L., Modney, B.K., Boulis, N.M., and Muller, K.J. 1994. The S cell: An interneuron essential for sensitization and full dishabituation of leech shortening. J. Neurosci. 14: 6715-6721.
28. Salin, P.A., Malenka, R.C., and Nicoll, R.A. 1996. Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron 16: 797-803.
29. Spencer, W.A., Thompson, R.F., and Nielson Jr., D.R. 1966. Response decrement of the flexion reflex in the acute spinal cat and transient restoration by strong stimuli. J. Neurophysiol. 29: 221-239.
30. Wright, W.G., Marcus, E.A., and Carew, T.J. 1991. A cellular analysis of inhibition in the siphon withdrawal reflex of Aplysia. J. Neurosci. 11: 2498-2509.
31. Yasuda, H., Barth, A.L., Stellwagen, D., and Malenka, R.C. 2003. A developmental switch in the signaling cascade for LTP induction. Nat. Neurosci. 6: 15-16.
32. Zakharenko, S.S., Patterson, S.L., Dragatsis, I., Zeitlin, S.O., Siegelbaum, S.A., Kandel, E.R., and Morozov, A. 2003. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 39: 975-990.
33. Zalutsky, R.A. and Nicoll, R.A. 1990. Comparison of two forms of long-term potentiation in single hippocampal neurons. Science 248: 1619-1624.