Association of endothelial nitric oxide synthase genotypes with bone mineral density, bone loss, hip structure, and risk of fracture in older women: The SOF study

Bone

Volumn 39, Issue 1, 2006, Pages 174-180

  Taylor, Brent C ^a,b   Schreiner, Pamela J ^b   Zmuda, Joseph M ^c   Li, Jia ^d   Moffett, Susan P ^c   Beck, Thomas J ^e   Cummings, Steven R ^f,g   Lee, Jocelyn M ^d   Walker, Karen ^d   Ensrud, Kristine E ^a,b,h  

^a VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d ROCHE MOLECULAR SYSTEMS   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^g UCSF Department of Epidemiology   (United States)

^h UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Aged; Bone density; Candidate genes; Fractures; Nitric oxide synthase

Indexed keywords

ASPARTIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTAMINE;

AGED; ALLELE; ARTICLE; BONE DENSITY; BONE RADIOGRAPHY; BONE STRENGTH; BONE STRUCTURE; CALCANEUS; CONTROLLED STUDY; DNA FLANKING REGION; DNA POLYMORPHISM; FEMALE; FOLLOW UP; FRACTURE; FRAGILITY FRACTURE; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY; HIP; HIP FRACTURE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MORPHOMETRICS; OSTEOLYSIS; PROMOTER REGION; RISK ASSESSMENT; SPINE; SPINE RADIOGRAPHY; STATISTICAL SIGNIFICANCE; VERTEBRA FRACTURE;

AGE FACTORS; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; ASPARAGINE; BONE DENSITY; CALCANEUS; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLLOW-UP STUDIES; FRACTURES, BONE; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HIP; HIP FRACTURES; HUMANS; INCIDENCE; NITRIC OXIDE SYNTHASE TYPE III; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, GENETIC; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; SPINAL FRACTURES; TIME FACTORS; UNITED STATES;

EID: 33744800241     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2005.12.080     Document Type: Article

References (36)

1. Moncada S., and Higgs A. The l-arginine-nitric oxide pathway. N. Engl. J. Med. 329 (1993) 2002-2012
2. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6 (1992) 3051-3064
3. Armour K.E., Armour K.J., Gallagher M.E., Godecke A., Helfrich M.H., Reid D.M., et al. Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology 142 (2001) 760-766
4. Helfrich M.H., Evans D.E., Grabowski P.S., Pollock J.S., Ohshima H., and Ralston S.H. Expression of nitric oxide synthase isoforms in bone and bone cell cultures. J. Bone Miner. Res. 12 (1997) 1108-1115
5. Hukkanen M.V., Platts L.A., Fernandez dM.I., O'Shaughnessy M., MacIntyre I., and Polak J.M. Developmental regulation of nitric oxide synthase expression in rat skeletal bone. J. Bone Miner. Res. 14 (1999) 868-877
6. Klein-Nulend J., Helfrich M.H., Sterck J.G., MacPherson H., Joldersma M., Ralston S.H., et al. Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent. Biochem. Biophys. Res. Commun. 250 (1998) 108-114
7. Diwan A.D., Wang M.X., Jang D., Zhu W., and Murrell G.A. Nitric oxide modulates fracture healing. J. Bone Miner. Res. 15 (2000) 342-351
8. Tsukahara H., Miura M., Tsuchida S., Hata I., Hata K., Yamamoto K., et al. Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats. Am. J. Physiol. 270 (1996) E840-E845
9. Corbett S.A., McCarthy I.D., Batten J., Hukkanen M., Polak J.M., and Hughes S.P. Nitric oxide mediated vasoreactivity during fracture repair. Clin. Orthop. (1999) 247-253
10. Aguirre J., Buttery L., O'Shaughnessy M., Afzal F., Fernandez dM.I., Hukkanen M., et al. Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity. Am. J. Pathol. 158 (2001) 247-257
11. Caballero-Alias A.M., Loveridge N., Pitsillides A., Parker M., Kaptoge S., Lyon A., et al. Osteocytic expression of constitutive NO synthase isoforms in the femoral neck cortex: a case-control study of intracapsular hip fracture. J. Bone Miner. Res. 20 (2005) 268-273
12. Asakimori Y., Yorioka N., Tanaka J., Takasugi N., Harada S., Shigemoto K., et al. Association between ENOS gene polymorphism and cardiovascular events in nondiabetic hemodialysis patients: a prospective study. Am. J. Kidney Dis. 44 (2004) 112-120
13. Gouni-Berthold I., Giannakidou E., Muller-Wieland D., Faust M., Kotzka J., Berthold H.K., et al. Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2. J. Hypertens. 23 (2005) 301-308
14. Gerritsen M.E. Genetic variations in vascular endothelial growth factor and endothelial nitric oxide synthase and their contributions to human disease. Microcirculation 12 (2005) 129-140
15. Albrecht E.W., Stegeman C.A., Heeringa P., Henning R.H., and van Goor H. Protective role of endothelial nitric oxide synthase. J. Pathol. 199 (2003) 8-17
16. Tesauro M., Thompson W.C., Rogliani P., Qi L., Chaudhary P.P., and Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 2832-2835
17. Cummings S.R., Nevitt M.C., Browner W.S., Stone K., Fox K.M., Ensrud K.E., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N. Engl. J. Med. 332 (1995) 767-773
18. Farmer M.E., White L.R., Brody J.A., and Bailey K.R. Race and sex differences in hip fracture incidence. Am. J. Public Health 74 (1984) 1374-1380
19. Cheng S., Grow M.A., Pallaud C., Klitz W., Erlich H.A., Visvikis S., et al. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res. 9 (1999) 936-949
20. Black D.M., Cummings S.R., Genant H.K., Nevitt M.C., Palermo L., and Browner W. Axial and appendicular bone density predict fractures in older women. J. Bone Miner. Res. 7 (1992) 633-638
21. Cummings S.R., Black D.M., Nevitt M.C., Browner W.S., Cauley J.A., Genant H.K., et al. Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA 263 (1990) 665-668
22. Cummings S.R., Black D.M., Nevitt M.C., Browner W., Cauley J., Ensrud K., et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 341 (1993) 72-75
23. Steiger P., Cummings S.R., Black D.M., Spencer N.E., and Genant H.K. Age-related decrements in bone mineral density in women over 65. J. Bone Miner. Res. 7 (1992) 625-632
24. Beck T.J., Ruff C.B., Warden K.E., Scott Jr. W.W., and Rao G.U. Predicting femoral neck strength from bone mineral data. A structural approach. Invest. Radiol. 25 (1990) 6-18
25. Beck T.J., Looker A.C., Ruff C.B., Sievanen H., and Wahner H.W. Structural trends in the aging femoral neck and proximal shaft: analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data. J. Bone Miner. Res. 15 (2000) 2297-2304
26. Beck T.J., Oreskovic T.L., Stone K.L., Ruff C.B., Ensrud K., Nevitt M.C., et al. Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J. Bone Miner. Res. 16 (2001) 1108-1119
27. Nevitt M.C., Cummings S.R., Browner W.S., Seeley D.G., Cauley J.A., Vogt T.M., et al. The accuracy of self-report of fractures in elderly women: evidence from a prospective study. Am. J. Epidemiol. 135 (1992) 490-499
28. Black D.M., Palermo L., Nevitt M.C., Genant H.K., Epstein R., San Valentin R., et al. Comparison of methods for defining prevalent vertebral deformities: the Study of Osteoporotic Fractures. J. Bone Miner. Res. 10 (1995) 890-902
29. Eastell R., Cedel S.L., Wahner H.W., Riggs B.L., and Melton III L.J. Classification of vertebral fractures. J. Bone Miner. Res. 6 (1991) 207-215
30. Black D.M., Cummings S.R., Stone K., Hudes E., Palermo L., and Steiger P. A new approach to defining normal vertebral dimensions. J. Bone Miner. Res. 6 (1991) 883-892
31. Black D.M., Palermo L., Nevitt M.C., Genant H.K., Christensen L., and Cummings S.R. Defining incident vertebral deformity: a prospective comparison of several approaches. The Study of Osteoporotic Fractures Research Group. J. Bone Miner. Res. 14 (1999) 90-101
32. Sands M.L., Schwartz A.V., Brown B.W., Nevitt M.C., Seeley D.G., and Kelsey J.L. Relationship of neurological function and age in older women. The study of osteoporotic fractures. Neuroepidemiology 17 (1998) 318-329
33. Jette A.M., Jette D.U., Ng J., Plotkin D.J., and Bach M.A. Are performance-based measures sufficiently reliable for use in multicenter trials? Musculoskeletal Impairment (MSI) Study Group. J. Gerontol., A, Biol. Sci. Med. Sci. 54 (1999) M3-M6
34. Yaffe K., Grady D., Pressman A., and Cummings S. Serum estrogen levels, cognitive performance, and risk of cognitive decline in older community women. J. Am. Geriatr. Soc. 46 (1998) 816-821
35. Fox K.M., Cummings S.R., Powell-Threets K., and Stone K. Family history and risk of osteoporotic fracture. Study of Osteoporotic Fractures Research Group. Osteoporos. Int. 8 (1998) 557-562
36. Poirier O., Mao C., Mallet C., Nicaud V., Herrmann S.M., Evans A., et al. Polymorphisms of the endothelial nitric oxide synthase gene - no consistent association with myocardial infarction in the ECTIM study. Eur. J. Clin. Invest. 29 (1999) 284-290