Hepatobiliary membrane transporters involving in the formation of cholesterol calculus

Hepatobiliary and Pancreatic Diseases International

Volumn 5, Issue 2, 2006, Pages 286-289

  Kong, Fan Min ^a   Sui, Chun Yang ^a   Li, Yu Ji ^a   Guo, Ke Jian ^a   Guo, Ren Xuan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Bile salt export pump; Cholecyst cholesterol lithiasis; Multidrug resistance protein 2; Multiple drug resistance 3

Indexed keywords

BILE SALT EXPORT PUMP; CARRIER PROTEIN; CHOLESTEROL; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHOLELITHIASIS; CHOLESTEROL STONE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; INFORMED CONSENT; LIVER BIOPSY; MALE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STONE FORMATION; WESTERN BLOTTING;

ADULT; BASE SEQUENCE; CASE-CONTROL STUDIES; CHOLELITHIASIS; CHOLESTEROL; DOWN-REGULATION; FEMALE; GALLSTONES; GENE EXPRESSION REGULATION; GENETIC MARKERS; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROBABILITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 33744794296     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. van Berge-Henegouwen GP, Venneman NG, Portincasa P, Kosters A, van Erpecum KJ, Groen AK. Relevance of hereditary defects in lipid transport proteins for the pathogenesis of cholesterol gallstone disease. Scand J Gastroenterol Suppl 2004;60-69.
2. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003;83: 633-671.
3. Hoda F, Green RM. Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation. J Membr Biol 2003;196:9-14.
4. Madon J, Eckhardt U, Gerloff T, Stieger B, Meier PJ. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett 1997;406:75-78.
5. Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 1997;26: 1667-1677.
6. Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, Thompson JR, et al. Farnesoid X receptor activates transcription of the phospholipid pump MDR3. J Biol Chem 2003;278: 51085-51090.
7. Meier PJ, Stieger B. Bile salt transporters. Annu Rev Physiol 2002;64:635-661.
8. Fitscher BA, Ehehalt R, Jochims C, Pohl J, Herrmann T, Stremmel W. Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system. Eur J Med Res 2000;5:517-522.
9. Plass JR, Mol O, Heegsma J, Geuken M, de Bruin J, Elling G, et al. A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump. J Hepatol 2004;40:24-30.
10. Cavestro GM, Frulloni L, Cerati E, Ribeiro LA, Corrente V, Sianesi M, et al. Progressive familial intrahepatic cholestasis. Acta Biomed Ateneo Parmense 2002;73:53-56.
11. Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet 1998;20:233-238.
12. Fickert P, Fuchsbichler A, Wagner M, Zollner G, Kaser A, Tilg H, et al. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2004;127:261-274.
13. Wang R, Salem M, Yousef IM, Tuchweber B, Lam P, Childs SJ, et al. Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc Natl Acad Sci USA 2001; 98:2011-2016.
14. Hoda F, Green RM. Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation. J Membr Biol 2003;196:9-14.
15. Shoda J, Oda K, Suzuki H, Sugiyama Y, Ito K, Cohen DE, et al. Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi. Hepatology 2001;33:1194-1205.
16. Lucena JF, Herrero JI, Quiroga J, Sangro B, Garcia-Foncillas J, Zabalegui N, et al. A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. Gastroenterology 2003;124:1037-1042.
17. Smit JJ, Schinkel AH, Oude Elferink RP, Groen AK, Wagenaar E, van Deemter L, et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993;75:451-462.