The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection

Journal of Bone and Joint Surgery

Volumn 88, Issue 6, 2006, Pages 1208-1214

  Mecikoglu, Mete ^a   Saygi, Baransel ^a   Yildirim, Yakup ^b   Karadag Saygi, Evrim ^c   Ramadan, Saime Sezgin ^c   Esemenli, Tanil ^c  

^a PTT Hospital   (Turkey)

^b ACIBADEM HOSPITAL   (Turkey)

^c MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

OFLOXACIN; SERRATIOPEPTIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ERADICATION THERAPY; EXPERIMENTAL INFECTION; HISTOPATHOLOGY; IMPLANT; KIRSCHNER WIRE; MICROBIOLOGICAL EXAMINATION; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSTHESIS INFECTION; PROTEIN DEGRADATION; RAT; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION; TOTAL KNEE REPLACEMENT;

EID: 33744793461     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/JBJS.E.00007     Document Type: Article

References (37)

1. Hirakawa K, Stulberg BN, Wilde AH, Bauer TW, Secic M. Results of 2-stage re-implantation for infected total knee arthroplasty. J Arthroplasty. 1998;13:22-8.
2. Hanssen AD. Managing the infected knee: as good as it gets. J Arthroplasty. 2002;17(4 Suppl 1):98-101.
3. Durbhakula SM, Czajka J, Fuchs MD, Uhl RL. Antibiotic-loaded articulating cement spacer in the 2-stage exchange of the infected total knee arthroplasty. J Arthroplasty. 2004;19:768-74.
4. Insall JN, Thompson FM, Brause BD. Two-stage reimplantation for the salvage of infected total knee arthroplasty. J Bone Joint Surg Am. 1983;65:1087-98.
5. Windsor RE, Insall JN, Urs WK, Miller DV, Brause BD. Two-stage reimplantation for the salvage of total knee arthroplasty complicated by infection. Further follow-up and refinement of indications. J Bone Joint Surg Am. 1990;72:272-8.
6. Bengtson S. Prosthetic osteomyelitis with special reference to the knee: risks, treatment and costs. Ann Med. 1993;25:523-9.
7. Ivey FM, Hicks CA, Calhoun JH, Mader JT. Treatment options for infected knee arthroplasties. Rev Infect Dis. 1990;12:468-78.
8. Norden C, Nelson JD, Mader JT, Calandra GB. Evaluation of new anti-infective drugs for the treatment of infections of prosthetic hip joints: Infectious Diseases Society of America and the Food and Drug Association. Clin Infect Dis. 1992;15 Suppl 1:5177-81.
9. Lucke M, Schmidmaier G, Sadoni S, Wildemann B, Schiller R, Stemberger A, Haas NP, Raschke M. A new model of implant-related osteomyelitis in rats. J Biomed Mater Res B Appl Biomater. 2003;67:593-602.
10. Blomgren G, Lundquist H, Nord CE, Lindgren U. Late anaerobic haematogenous infection of experimental total joint replacement. A study in the rabbit using Propionibacterium acnes. J Bone Joint Surg Br. 1981;63:614-8.
11. Gristina AG, Costerton JW. Bacterial adherence to biomaterials and tissue. The significance of its role in clinical sepsis. J Bone Joint Surg Am. 1985;67:264-73.
12. Alcaraz LE, Satorres SE, Lucero RM, de Centorbi ONP. Species identification, slime production and oxacillin susceptibility in coagulase-negative staphylococci isolated from nosocomial specimens. Braz J Microbiol. 2003;34:45-51.
13. Yamasaki H, Tsuji H, Saeki K. [Anti-inflammatory action of a protease, TSP, produced by Serratia]. Nippon Yakurigaku Zasshi. 1967;63:302-14. Japanese.
14. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 1999;47:1170-2.
15. Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes: randomised, double-blind study versus Diclofenac. Clin Drug Invest. 2000;19:15-23.
16. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244:355-9.
17. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J Int Med Res. 1990;18:379-88.
18. Tachibana M, Mizukoshi O, Harada Y, Kawamoto K, Nakai Y. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica. 1984;3:526-30.
19. Esch PM, Gerngross H, Fabian A. [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase - a prospective study]. Fortschr Med. 1989;107:67-8, 71-2. German.
20. Selan L, Berlutti F, Passariello C, Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Chemother. 1993;37:2618-21.
21. Kakinuma A, Moriya N, Kawahara K, Sugino H. Repression of fibrinolysis in scalded rats by administration of Serratia protease. Biochem Pharmacol. 1982;31:2861-6.
22. Aratani H, Tateishi H, Negita S. [Studies on the distributions of antibiotics in the oral tissues: experimental staphylococcal infection in rats, and effect of serratiopeptidase on the distributions of antibiotics (author's transl)]. Jpn J Antibiot. 1980;33:623-35. Japanese.
23. Rodeheaver G, Wheeler CB, Rye DG, Vensko J, Edlich RF. Side-effects of topical proteolytic enzyme treatment. Surg Gynecol Obstet. 1979;148:562-6.
24. Rodeheaver G, Rye DG, Rust R, Marsh D, Edgerton MT, Edlich RF. Mechanisms by which proteolytic enzymes prolong the golden period of antibiotic action. Am J Surg. 1978;136:379-82.
25. Johansen C, Falholt P, Gram L. Enzymatic removal and disinfection of bacterial biofilms. Appl Environ Microb. 1997;63:3724-8.
26. Petty W, Spaniers, Shuster JJ, Silverthorne C. The influence of skeletal implants on incidence of infection. Experiments in a canine model. J Bone Joint Surg Am. 1985;67:1236-44.
27. Cordero J, Munuera L, Folgueira MD. Influence of metal implants on infection. An experimental study in rabbits. J Bone Joint Surg Br. 1994;76:717-20.
28. Rupp ME, Hamer KE. Effect of subinhibitory concentrations of vancomycin, cefazolin, ofloxacin, L-ofloxacin and D-ofloxacin on adherence to intravascular catheters and biofilm formation by Staphylococcus epidermidis. J Antimicrob Chemother. 1998;41:155-61.
29. Korkusuz F, Uchida A, Shinto Y, Araki N, Inoue K, Ono K. Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites. J Bone Joint Surg Br. 1993;75:111-4.
30. An YH, Friedman RJ. Animal models of orthopedic implant infection. J Invest Surg. 1998;11:139-46.
31. Howie DW, Vernon-Roberts B, Oakeshott R, Manthey B. A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles. J Bone Joint Surg Am. 1988;70:257-63.
32. Nakamoto DA, Rosenfield ML, Haaga JR, Merritt K, Sachs PB, Hutton MC, Graham RC, Rowland DY. In vivo treatment of infected prosthetic graft material with urokinase: an animal model. J Vasc Interv Radiol. 1994;5:549-52.
33. Okumura H, Watanabe R, Kotoura Y, Nakane Y, Tangiku O. [Effects of a proteolytic-enzyme preparation used concomitantly with an antibiotic in osteoarticular infections (author's transl)]. Jpn J Antibiot. 1977;30:223-7.
34. Petty W, Spanier S, Shuster JJ. Prevention of infection after total joint replacement. Experiments with a canine model. J Bone Joint Surg Am. 1988;70:536-9.
35. Jin T, Tarkowski A, Carmeliet P, Bokarewa M. Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis. Arthritis Res Ther. 2003;5:R9-R17.
36. Shimizu H, Ueda M, Takai T, Bito T, Ichihashi M, Muramatsu T, Shirai T. A case of serratiopeptidase-induced subepidermal bullous dermatosis. Br J Dermatol. 1999;141:1139-40.
37. Sasaki S, Kawanami R, Motizuki Y, Nakahara Y, Kawamura T, Tanaka A, Watanabe S. [Serrapeptase-induced lung injury manifesting as acute eosiniphilic pneumonia]. Nihon Kokyuki Gakkai Zasshi. 2000;38:540-4. Japanese.