Use of Intralipid for kinetic analysis of HDL apoC-III: Evidence for a homogeneous kinetic pool of apoC-III in plasma

Journal of Lipid Research

Volumn 47, Issue 6, 2006, Pages 1274-1280

  Nguyen, Minh N ^a   Chan, Dick C ^a   Dwyer, Kevin P ^a   Bolitho, Paul ^a   Watts, Gerald F ^a   Barrett, P Hugh R ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Apolipoprotein C III; Gas chromatography mass spectrometry; High density lipoprotein; Lipoprotein; Metabolism; Very low density lipoprotein

Indexed keywords

APOLIPOPROTEIN C3; HIGH DENSITY LIPOPROTEIN; INTRALIPID; ISOLEUCINE; LEUCINE; RADIOISOTOPE; STABLE ISOTOPE; TRACER;

ADULT; ARTICLE; CATABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; GEL ELECTROPHORESIS; HUMAN; ISOELECTRIC FOCUSING; LIPOPROTEIN METABOLISM; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 33744780706     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600018-JLR200     Document Type: Article

References (39)

1. Brown, V. W., and M. L. Baginsky. 1972. Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein. Biochem. Biophys. Res. Commun. 46: 375-382.
2. Havel, R. J., C. J. Fielding, T. Olivecrona, V. G. Shore, P. E. Fielding, and T. Egelrud. 1973. Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoprotein lipase from different sources. Biochemistry. 12: 1828-1833.
3. Windler, E., Y. Chao, and R. J. Havel. 1980. Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins. J. Biol. Chem. 255: 8303-8307.
4. Sehayek, E., and S. Eisenberg. 1991. Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266: 18259-18267.
5. 125I-labeled very low density lipoproteins using immunoaffinity chromatography. J. Lipid Res. 24: 1251-1260.
6. Kashyap, M. L., L. S. Srivastava, B. A. Hynd, P. S. Gartside, and G. Perisutti. 1981. Quantitation of human apolipoprotein C-III and its subspecies by radioimmunoassay and analytical isoelectric focusing: abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecies concentrations in hypertriglyceridemia. J. Lipid Res. 22: 800-810.
7. Sacks, F. M., P. Alaupovic, L. A. Moye, T. G. Cole, B. Sussex, M. J. Stampfer, M. A. Pfeffer, and E. Braunwald. 2000. VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial. Circulation. 102: 1886-1892.
8. Hodis, H. N. 1999. Triglyceride-rich lipoprotein remnant particles and risk of atherosclerosis. Circulation. 99: 2852-2854.
9. Ginsberg, H. N. 2002. New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism. Circulation. 106: 2137-2142.
10. Le, N. A., J. C. Gibson, and H. N. Ginsberg. 1988. Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins. J. Lipid Res. 29: 669-677.
11. Cohn, J. S., R. Batal, M. Tremblay, H. Jacques, L. Veilleux, C. Rodriguez, O. Mamer, and J. Davignon. 2003. Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans: in vivo evidence for a link between HDL apoC-III and apoA-I metabolism. J. Lipid Res. 44: 1976-1983.
12. Brewer, H. B., Jr., R. Shulman, P. Herbert, R. Ronan, and K. Wehrly. 1974. The complete amino acid sequence of alanine apolipoprotein (apoC-III), an apolipoprotein from human plasma very low density lipoproteins. J. Biol. Chem. 249: 4975-4984.
13. Catapano, A. L., R. L. Jackson, E. B. Gilliam, A. M. Gotto, Jr., and L. C. Smith. 1978. Quantification of apoC-II and apoC-III of human very low density lipoproteins by analytical isoelectric focusing. J. Lipid Res. 19: 1047-1052.
14. Huff, M. W., N. H. Fidge, P. J. Nestel, T. Billington, and B. Watson. 1981. Metabolism of C-apolipoproteins: kinetics of C-II, C-III1 and C-III2, and VLDL-apolipoprotein B in normal and hyperlipoproteinemic subjects. J. Lipid Res. 22: 1235-1246.
15. Fidge, N. H., and P. J. Nestel. 1986. Metabolism of apolipoprotein C. Methods Enzymol. 129: 443-457.
16. Malmendier, C. L., J. F. Lontie, G. A. Grutman, and C. Delcroix. 1988. Metabolism of apolipoprotein C-III in normolipemic human subjects. Atherosclerosis. 69: 51-59.
17. McKeone, B. J., J. B. Massey, R. D. Knapp, and H. J. Pownall. 1988. Apolipoproteins C-I, C-II, and C-III: kinetics of association with model membranes and intermembrane transfer. Biochemistry. 27: 4500-4505.
18. Bilheimer, D. W., S. Eisenberg, and R. I. Levy. 1972. The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations. Biochim. Biophys. Acta. 260: 212-221.
19. Bukberg, P. R., N. A. Le, H. N. Ginsberg, J. C. Gibson, A. Rubinstein, and W. V. Brown. 1985. Evidence for non-equilibrating pools of apolipoprotein C-III in plasma lipoproteins. J. Lipid Res. 26: 1047-1057.
20. Tornoci, L., C. A. Scheraldi, X. Li, H. Ide, I. J. Goldberg, and N. A. Le. 1993. Abnormal activation of lipoprotein lipase by non-equilibrating apoC-II: further evidence for the presence of non-equilibrating pools of apolipoproteins C-II and C-III in plasma lipoproteins. J. Lipid Res. 34: 1793-1803.
21. Le, N. A., P. R. Bukberg, H. N. Ginsberg, J. C. Gibson, and V. W. Brown. 1996. Direct determination of apolipoprotein C-III specific activity using immunoaffinity chromatography. Methods Enzymol. 129: 457-469.
22. Batal, R., M. Tremblay, P. H. R. Barrett, H. Jacques, A. Fredenrich, O. Mamer, J. Davignon, and J. S. Cohn. 2000. Plasma kinetics of apoC-III and apoE in normolipidemic and hypertriglyceridemic subjects. J. Lipid Res. 41: 706-718.
23. Astrup, H. N., and G. Bengtsson. 1982. Activator proteins for lipoprotein lipase from bovine plasma: preparation by adsorption to Intralipid. Comp. Biochem. Physiol. B. 72: 487-491.
24. Chan, D. C., G. F. Watts, T. G. Redgrave, T. A. Mori, and P. H. R. Barrett. 2002. Apolipoprotein B-100 kinetics in visceral obesity: associations with plasma apolipoprotein C-III concentration. Metabolism. 51: 1041-1046.
25. Batal, R., M. Tremblay, L. Krimbou, O. Mamer, J. Davignon, J. Genest, Jr., and J. S. Cohn. 1998. Familial HDL deficiency characterized by hypercatabolism of mature apoA-I but not proapoA-I. Arterioscler. Thromb. Vasc. Biol. 18: 655-664.
26. Schmitz, G., K. Ilsemann, B. Melnik, and G. Assmann. 1983. Isoproteins of human apolipoprotein A-II: isolation and characterization. J. Lipid Res. 24: 1021-1029.
27. Weisgraber, K. H., S. C. Rall, Jr., and R. W. Mahley. 1981. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J. Biol. Chem. 256: 9077-9083.
28. Holmquist, L., and K. Carlson. 1977. Selective extraction of human serum very low density apolipoproteins with organic solvents. Biochim. Biophys. Acta. 493: 400-409.
29. Menzel, H. J., R. G. Kladetzky, and G. Assmann. 1982. One-step screening method for the polymorphism of apolipoproteins A-I, A-II, and A-IV. J. Lipid Res. 23: 915-922.
30. Kashyap, M. L. 1996. Immunochemical methods for quantification of human apolipoprotein C-III. Methods Enzymol. 263: 208-218.
31. Albers, J. J., and A. M. Scanu. 1971. Isoelectric fractionation and characterization of polypeptides from human serum very low density lipoproteins. Biochim. Biophys. Acta. 236: 29-37.
32. Dwyer, K. P., P. H. R. Barrett, D. Chan, J. I. Foo, G. F. Watts, and K. D. Croft. 2002. Oxazolinone derivative of leucine for GC-MS: a sensitive and robust method for stable isotope kinetic studies of lipoproteins. J. Lipid Res. 43: 344-349.
33. Andersson, Y., S. Nilsson, A. Lindberg, L. Thelander, and G. Olivecrona. 1996. Apolipoprotein CII from chicken (Gallus domesticus). The amino-terminal domain is different from corresponding domains in mammals. J. Biol. Chem. 271: 33060-33066.
34. Brites, F. D., C. D. Bonavita, M. Cloes, M. J. Yael, J-C. Fruchart, G. R. Castro, and R. W. Wikinski. 1998. VLDL compositional changes and plasma levels of triglycerides and high density lipoprotein. Clin. Chim. Acta. 269: 107-124.
35. Cohn, J. S., B. W. Patterson, K. D. Uffelman, J. Davignon, and G. Steiner. 2004. Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J. Clin. Endocrinol. Metab. 89: 3949-3955.
36. Cohn, J. S., M. Tremblay, R. Batal, H. Jacques, C. Rodriguez, G. Steiner, O. Mamer, and J. Davignon. 2004. Increased apoC-III production is a characteristic feature of patients with hypertriglyceridemia. Atherosclerosis. 177: 137-145.
37. Malmendier, C. L., J. F. Lontie, C. Delcroix, D. Y. Dubois, T. Magot, and L. De Roy. 1989. Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis. 77: 139-149.
38. Carlson, L. A. 1980. Studies on the fat emulsion Intralipid. I. Association of serum proteins to Intralipid triglyceride particles (ITP). Scand. J. Clin. Lab. Invest. 40: 1139-1144.
39. Chan, D. C., G. F. Watts, M. N. Nguyen, and P. H. R. Barrett. 2006. Apolipoproteins C-III and A-V as predictors of very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics. Arterioscler. Thromb. Vasc. Biol. 26: 590-596.