Schizophrenia and cancer risk: Can the CCR5-delta 32 chemokine receptor gene mutation play a role?

Medical Hypotheses

Volumn 67, Issue 2, 2006, Pages 427-428

  Geroldi, Diego ^a   Emanuele, Enzo ^a   Martinelli, Valentina ^a   Pesenti, Sara ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ALLELE; ANGIOGENESIS; CANCER RISK; CARCINOGENESIS; EXTRAVASATION; GENE DELETION; GENE EXPRESSION; GENETIC RESISTANCE; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; LETTER; LUNG CANCER; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA; TUMOR RESISTANCE;

HUMANS; MUTATION; NEOPLASMS; RECEPTORS, CCR5; RISK; SCHIZOPHRENIA; SEQUENCE DELETION;

EID: 33744764587     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.03.008     Document Type: Letter

References (7)

1. Dalton S.O., Laursen T.M., Mellemkjaer L., Johansen C., and Mortensen P.B. Risk for cancer in parents of patients with schizophrenia. Am J Psychiatry 161 (2004) 903-908
2. Catts V.S., and Catts S.V. Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?. Schizophr Res 41 (2000) 405-415
3. Rasmussen H.B., Timm S., Wang A.G., et al. Association between the CCR5 32-bp deletion allele and late onset of schizophrenia. Am J Psychiatry 163 (2006) 507-511
4. Sabeti P.C., Walsh E., Schaffner S.F., et al. The case for selection at CCR5-Delta32. PLoS Biol 3 (2005) e378
5. van Deventer H.W., O'Connor Jr. W., Brickey W.J., Aris R.M., Ting J.P., and Serody J.S. C-C chemokine receptor 5 on stromal cells promotes pulmonary metastasis. Cancer Res 65 (2005) 3374-3379
6. Ng-Cashin J., Kuhns J.J., Burkett S.E., et al. Host absence of CCR5 potentiates dendritic cell vaccination. J Immunol 170 (2003) 4201-4208
7. Dean M., Jacobson L.P., McFarlane G., et al. Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation. Cancer Res 59 (1999) 3561-3564