Novel manufacturing process of hollow polymer microspheres

Chemical Engineering Science

Volumn 61, Issue 15, 2006, Pages 4973-4981

  Schmidt, Wolfgang ^a   Roessling, Georg ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Bubble; Microspheres; Modeling; Particle formation; Pharmaceuticals; Polymerization

Indexed keywords

BUBBLES (IN FLUIDS); COMPUTER SIMULATION; DRUG PRODUCTS; PARTICLE SIZE ANALYSIS; POLYMERIZATION; SYNTHESIS (CHEMICAL); ULTRASONICS; VOLUME FRACTION;

MICROSPHERES; MODELING; PARTICLE FORMATION;

POLYMERS;

BUBBLES (IN FLUIDS); COMPUTER SIMULATION; DRUG PRODUCTS; PARTICLE SIZE ANALYSIS; POLYMERIZATION; POLYMERS; SYNTHESIS (CHEMICAL); ULTRASONICS; VOLUME FRACTION;

EID: 33744535434     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2006.03.021     Document Type: Article

References (26)

1. Behan N., et al. Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation. Biomaterials 22 (2001) 1335-1344
2. Berkland C., et al. Uniform double-walled polymer microspheres of controllable shell thickness. Journal of Controlled Release 96 (2004) 101-111
3. Boal A.K., et al. Self-assembly of nanoparticles into structured spherical and network aggregates. Nature 404 (2004) 746-748
4. Brandau T. Preparation of monodisperse controlled release microcapsules. International Journal of Pharmaceutics 242 (2002) 179-184
5. Crotts G., and Park T.G. Preparation of porous and nonporous biodegradable polymeric hollow microspheres. Journal of Controlled Release 35 (1995) 91-105
6. de Jong N., et al. Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics 30 (1992) 95-103
7. Dayton P.A., and Ferrara K.W. Targeted imaging using ultrasound. Journal of Magnetic Resonance Imaging 16 (2002) 362-377
8. Deshpande N.S., and Barigou M. The flow of gas-liquid foams in vertical pipes. Chemical Engineering Science 55 (2000) 4297-4309
9. Dinsmore A.D., et al. Colloidosomes: selectively permeable capsules composed of colloidal particles. Science 298 (2002) 1006-1009
10. Jin-Woong K., et al. Multihollow polymer microcapsules by water-in-oil-in-water emulsion polymerization: morphological study and entrapment characteristics. Colloid and Polymer Science 281 (2003) 157-163
11. Mayer S., and Grayburn P.A. Myocardial contrast agents: recent advances and future directions. Progress in Cardiovascular Diseases 44 (2001) 33-44
12. Narayan P., et al. Optimization of spray drying by factorial design for production of hollow microspheres for ultrasound imaging. Journal of Biomedical Materials Research 56 (2001) 333-341
13. Ottoboni, T., et. al., 2001. Microparticles useful as ultrasonic contrast agent. Patent US-6193951.
14. Paul W., and Jones R.V. Production and separation of small glass spheres. British Journal of Applied Physics 3 (1952) 311-314
15. Raisinghani A., and DeMaria A.N. Physical principles of microbubble ultrasound contrast agents. American Journal of Cardiology 90 10A (2002) 3J-7J
16. Rapoport N.Y., et al. Ultrasound-triggered drug targeting of tumors in vitro and in vivo. Ultrasonics 42 (2004) 943-950
17. Sato Y., et al. Physicochemical properties to determine the buoyancy of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. European Journal of Pharmaceutics and Biopharmaceutics 55 (2003) 297-304
18. Sato Y., et al. In vitro and in vivo evaluation of riboflavin-containing microballoons for a floating controlled drug delivery system in healthy humans. International Journal of Pharmaceutics 275 (2004) 97-107
19. Sommerfeld P., et al. Long-term stability of PBCA nanoparticle suspensions. Journal of Microencapsulation 17 (2000) 69-79
20. Sun Q., et al. The formation of well-defined hollow silica spheres with multilamellar shell structure. Advances in Materials 15 (2003) 1097-1100
21. Uhlendorf, V., Hoffmann, C.U.S., 1994. Non-linear acoustic response of coated microbubbles in diagnostic. Proceedings of IEEE Symposium, vol. 40, pp. 1559-1562.
22. Unger E.C., et al. Therapeutic applications of microbubbles. European Journal of Radiology 42 (2002) 160-168
23. Xia Y., et al. Monodispersed colloidal spheres: old materials with new applications. Advances in Materials 12 (2000) 693-713
24. Young, W.C., Budynas, R.G., 2002. Roark's Formulas for Stress and Strain, seventh ed. ISBN 0-07-072542-X, Table 15.2, Case 22.
25. 2 by templating against crystalline arrays of polystyrene beads. Advances in Materials 12 (2000) 206-209
26. Zlokarnik, M., 1999. Rührtechnik-Theorie und Praxis. Springer, Berlin, ISBN 3-540-64639-6, 79-86, 20.