메뉴 건너뛰기




Volumn 171, Issue 2, 2006, Pages 194-205

Screening for inhibitors of 2-oxoglutarate-dependent dioxygenases: Flavanone 3β-hydroxylase and flavonol synthase

Author keywords

2 Oxoglutarate analogous enzyme inhibitors; Dioxygenase; Flavanone 3 hydroxylase (FHT = F3H, EC 1.14.11.9); Flavonol synthase (FLS, EC 1.14.11.23); Pome fruits (apple, pear); Prohexadione Ca

Indexed keywords

BINDING ENERGY; BIOSYNTHESIS; FRUITS; SUBSTRATES;

EID: 33744521042     PISSN: 01689452     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plantsci.2006.03.014     Document Type: Article
Times cited : (42)

References (28)
  • 1
    • 0034485360 scopus 로고    scopus 로고
    • Growth retardants: effects on gibberellin biosynthesis and other metabolic pathways
    • Rademacher W. Growth retardants: effects on gibberellin biosynthesis and other metabolic pathways. Annu. Rev. Plant Physiol. Plant Mol. Biol. 51 (2000) 501-531
    • (2000) Annu. Rev. Plant Physiol. Plant Mol. Biol. , vol.51 , pp. 501-531
    • Rademacher, W.1
  • 2
    • 0141596122 scopus 로고    scopus 로고
    • Unusual flavonoid routes induced by the dioxygenase inhibitor prohexadione-Ca in apple (Malus domestica)
    • Römmelt S., Zimmermann N., Rademacher W., and Treutter D. Unusual flavonoid routes induced by the dioxygenase inhibitor prohexadione-Ca in apple (Malus domestica). Phytochemistry 64 (2003) 709-716
    • (2003) Phytochemistry , vol.64 , pp. 709-716
    • Römmelt, S.1    Zimmermann, N.2    Rademacher, W.3    Treutter, D.4
  • 3
    • 0141788088 scopus 로고    scopus 로고
    • Effect of dioxygenase inhibitors on the resistance-related flavonoid metabolism of apple and pears: chemical, biochemical and molecular biological aspects
    • Römmelt S., Fischer T.C., Halbwirth H., Peterek S., Schlangen K., Speakman J.B., Treutter D., Forkmann G., and Stich K. Effect of dioxygenase inhibitors on the resistance-related flavonoid metabolism of apple and pears: chemical, biochemical and molecular biological aspects. Eur. J. Hortic. Sci. 68 (2003) 129-136
    • (2003) Eur. J. Hortic. Sci. , vol.68 , pp. 129-136
    • Römmelt, S.1    Fischer, T.C.2    Halbwirth, H.3    Peterek, S.4    Schlangen, K.5    Speakman, J.B.6    Treutter, D.7    Forkmann, G.8    Stich, K.9
  • 5
    • 0345700352 scopus 로고    scopus 로고
    • Molecular cloning, substrate specificity of the functionally expressed dihydroflavonol 4-reductases from Malus domestica and Pyrus communis cultivars and the consequences for flavonoid metabolism
    • Fischer T.C., Halbwirth H., Meisel B., Stich K., and Forkmann G. Molecular cloning, substrate specificity of the functionally expressed dihydroflavonol 4-reductases from Malus domestica and Pyrus communis cultivars and the consequences for flavonoid metabolism. Arch. Biochem. Biophys. 412 (2003) 223-230
    • (2003) Arch. Biochem. Biophys. , vol.412 , pp. 223-230
    • Fischer, T.C.1    Halbwirth, H.2    Meisel, B.3    Stich, K.4    Forkmann, G.5
  • 6
    • 21144440199 scopus 로고    scopus 로고
    • Luteoforol, a flavan 4-ol, is induced in pome fruits by prohexadione-calcium and shows phytoalexin-like properties against Erwinia amylovora and other plant pathogens
    • Spinelli F., Speakman J.B., Rademacher W., Halbwirth H., Stich K., and Costa G. Luteoforol, a flavan 4-ol, is induced in pome fruits by prohexadione-calcium and shows phytoalexin-like properties against Erwinia amylovora and other plant pathogens. Eur. J. Plant Pathol. 112 (2005) 133-142
    • (2005) Eur. J. Plant Pathol. , vol.112 , pp. 133-142
    • Spinelli, F.1    Speakman, J.B.2    Rademacher, W.3    Halbwirth, H.4    Stich, K.5    Costa, G.6
  • 8
    • 0000680699 scopus 로고
    • Conversion of flavanone to flavone, dihydroflavonol and flavonol with an enzyme system from cell cultures of parsley
    • Britsch L., Heller W., and Grisebach H. Conversion of flavanone to flavone, dihydroflavonol and flavonol with an enzyme system from cell cultures of parsley. Z. Naturforsch. c 36 (1981) 741-750
    • (1981) Z. Naturforsch. c , vol.36 , pp. 741-750
    • Britsch, L.1    Heller, W.2    Grisebach, H.3
  • 9
    • 2442548759 scopus 로고    scopus 로고
    • The A-ring specific hydroxylation of flavonols in position 6 in Tagetes sp. is catalyzed by a cytochrome P450-dependent monooxygenase
    • Halbwirth H., Forkmann G., and Stich K. The A-ring specific hydroxylation of flavonols in position 6 in Tagetes sp. is catalyzed by a cytochrome P450-dependent monooxygenase. Plant Sci. 167 (2004) 129-135
    • (2004) Plant Sci. , vol.167 , pp. 129-135
    • Halbwirth, H.1    Forkmann, G.2    Stich, K.3
  • 10
    • 33744550647 scopus 로고    scopus 로고
    • H.G. Brunner, Cyclohexandion-carbonsäurederivate mit herbizider und das Pflanzenwachstum regulierender Wirkung, European Patent 0,126,713 (1989).
  • 11
    • 33744545085 scopus 로고    scopus 로고
    • D. Jahn, M. Keil, D. Kolassa, U. Schirmer, R. Becker, J. Jung, W. Rademacher, Mittel zur Regulierung des Pflanzenwachstums, European Patent 0,210,445 (1996).
  • 12
    • 33744505017 scopus 로고    scopus 로고
    • M. Keil, U. Schirmer, J. Kast, D. Kolassa, B. Würzer, N. Meyer, W. Rademacher, J. Jung, D. Carlson, Cyclohexenonverbindungen, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung als Herbizide oder als Pflanzenwachstum regulierende Mittel, European Patent 0,293,817 (1990).
  • 13
    • 33744542193 scopus 로고    scopus 로고
    • J.R. Lee, S.-T. Hong, Y.G. Yoo, S.-R. Kim, Unpublished, direct sequence submission 1998 to GenBank: AF117270 (FHT), AF119095 (FLS).
  • 14
    • 0027662248 scopus 로고
    • A cDNA clone for flavanone 3-hydroxylase from Malus
    • Davies K.M. A cDNA clone for flavanone 3-hydroxylase from Malus. Plant Physiol. 103 (1993) 291
    • (1993) Plant Physiol. , vol.103 , pp. 291
    • Davies, K.M.1
  • 15
    • 0030852872 scopus 로고    scopus 로고
    • Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5
    • Urban P., Mignotte C., Kazmaier M., Delorme F., and Pompon D. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. J. Biol. Chem. 272 (1997) 19176-19186
    • (1997) J. Biol. Chem. , vol.272 , pp. 19176-19186
    • Urban, P.1    Mignotte, C.2    Kazmaier, M.3    Delorme, F.4    Pompon, D.5
  • 16
    • 0015523546 scopus 로고
    • Purification and properties of C55-isoprenoid alcohol phosphokinase from Staphylococcus aureus
    • Sandermann H., and Strominger J.L. Purification and properties of C55-isoprenoid alcohol phosphokinase from Staphylococcus aureus. J. Biol. Chem. 247 (1972) 5123-5131
    • (1972) J. Biol. Chem. , vol.247 , pp. 5123-5131
    • Sandermann, H.1    Strominger, J.L.2
  • 17
    • 0011729762 scopus 로고
    • Separation of flavonoids by reversed-phase high-performance liquid chromatography
    • Vande Casteele K., Geiger H., and Van Sumere C.F. Separation of flavonoids by reversed-phase high-performance liquid chromatography. J. Chromatogr. 240 (1982) 81-94
    • (1982) J. Chromatogr. , vol.240 , pp. 81-94
    • Vande Casteele, K.1    Geiger, H.2    Van Sumere, C.F.3
  • 18
    • 0030062263 scopus 로고    scopus 로고
    • Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds
    • Wang B.H., and Polya G.M. Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds. Phytochemistry 41 (1996) 55-63
    • (1996) Phytochemistry , vol.41 , pp. 55-63
    • Wang, B.H.1    Polya, G.M.2
  • 19
    • 0000108147 scopus 로고
    • Inhibition of gibberellin 2β-hydroxylases by acylcyclohexanedione derivatives
    • Griggs D.L., Hedden P., Temple-Smith K.E., and Rademacher W. Inhibition of gibberellin 2β-hydroxylases by acylcyclohexanedione derivatives. Phytochemistry 30 (1991) 2513-2517
    • (1991) Phytochemistry , vol.30 , pp. 2513-2517
    • Griggs, D.L.1    Hedden, P.2    Temple-Smith, K.E.3    Rademacher, W.4
  • 20
    • 0023021512 scopus 로고
    • Partial identity of the 2-oxo-glutarate and ascorbate binding sites of prolyl 4-hydroxylase
    • Majamaa K., Günzler V., Hanauske-Abel H.M., Myllylä R., and Kivirikko K.I. Partial identity of the 2-oxo-glutarate and ascorbate binding sites of prolyl 4-hydroxylase. J. Biol. Chem. 261 (1986) 7819-7823
    • (1986) J. Biol. Chem. , vol.261 , pp. 7819-7823
    • Majamaa, K.1    Günzler, V.2    Hanauske-Abel, H.M.3    Myllylä, R.4    Kivirikko, K.I.5
  • 24
    • 33744541692 scopus 로고    scopus 로고
    • Falbe J., and Regitz M. (Eds), Georg Thieme Verlag, Stuttgart, New York
    • In: Falbe J., and Regitz M. (Eds). Römpp-Lexikon Chemie, Band 1 (1996), Georg Thieme Verlag, Stuttgart, New York 780
    • (1996) Römpp-Lexikon Chemie, Band 1 , pp. 780
  • 25
    • 0028117768 scopus 로고
    • Role of flavonoids and iron chelation in antioxidant action
    • Morel I., Lescoat G., Cillard P., and Cillard J. Role of flavonoids and iron chelation in antioxidant action. Meth. Enzymol. 234 (1994) 437-443
    • (1994) Meth. Enzymol. , vol.234 , pp. 437-443
    • Morel, I.1    Lescoat, G.2    Cillard, P.3    Cillard, J.4
  • 26
    • 0031844905 scopus 로고    scopus 로고
    • Dietary flavonoids interact with trace metals and affect metallothionein level in human intestinal cells
    • Kuo S.M., Leavitt P.S., and Lin C.P. Dietary flavonoids interact with trace metals and affect metallothionein level in human intestinal cells. Biol. Trace Element Res. 62 (1998) 135-153
    • (1998) Biol. Trace Element Res. , vol.62 , pp. 135-153
    • Kuo, S.M.1    Leavitt, P.S.2    Lin, C.P.3
  • 27
    • 0036827673 scopus 로고    scopus 로고
    • Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity
    • Mira L., Fernandez M.T., Santos M., Rocha R., Florencio M.H., and Jennings K. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic. Res. 36 (2002) 1199-1208
    • (2002) Free Radic. Res. , vol.36 , pp. 1199-1208
    • Mira, L.1    Fernandez, M.T.2    Santos, M.3    Rocha, R.4    Florencio, M.H.5    Jennings, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.