Polymer-supported synthesis of pyridone-focused libraries as inhibitors of anaplastic lymphoma kinase

Journal of Combinatorial Chemistry

Volumn 8, Issue 3, 2006, Pages 401-409

  Zhu, Tong ^a   Yan, Zheng ^a   Chucholowski, Alexander ^a   Webb, Thomas R ^a   Li, Rongshi ^a  

^a ChemBridge Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ENZYME INHIBITOR; POLYMER; PROTEIN TYROSINE KINASE; PYRIDONE DERIVATIVE;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; PHARMACEUTICS; STEREOISOMERISM; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ENZYME INHIBITORS; MODELS, CHEMICAL; POLYMERS; PROTEIN-TYROSINE KINASES; PYRIDONES; STEREOISOMERISM; TECHNOLOGY, PHARMACEUTICAL;

EID: 33744487688     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc060018r     Document Type: Article

References (16)

1. f Tagged Microreactors. In Optimization of Solid-Phase Combinatorial Synthesis; Yan, B., Czarnik, A. W., Eds.; Marcel Dekker: New York, 2001; pp 55-67.
2. (b) Li, R.; Xiao, X.-y.; Nicolaou, K. C. High-output Solid-Phase Synthesis of Discrete Compounds Using Split-and-Pool Strategy. In High-Throughput Organic Synthesis; Sucholeiki, I. Ed.; Marcel Dekker: New York, 2000; pp 207-213.
3. (a) Morris, S. W.; Kirstein, M. N.; Valentine, M. B.; Dittmer, K. G.; Shapiro, D. N.; Saltman, D. L.; Look, A. T. Science 1994, 263, 1281-1284.
4. (b) Iwahara, T.; Fujimoto, J.; Wen, D.; Cupples, R.; Bucay, N.; Arakawa, T.; Mori, S.; Ratzkin, B.; Yamamoto, T. Oncogene 1997, 14, 439-449.
5. (c) Morris, S. W.; Naeve, C.; Mathew, P.; James, P. L.; Kirstein, M. N.; Cui, X.; Witte, D. P. Oncogene 1997, 14, 2175-2188.
6. (d) Pulford, K. P.; Morris, S. W.; Turturro, F. J. Cell Physiol. 2004, 199, 330-358.
7. Li, R.; Xue, L.; Zhu, T.; Jiang, Q.; Cui, X.; Yan, Z.; McGee, D.; Wang, J.; Gantla, V. R.; Pickens, J. C.; McGrath, D.; Chucholowski, A.; Morris, S. W.; Webb, T. R. J. Med. Chem. 2006, 49, 1006-1015.
8. Wang, S.-S. J. Am. Chem. Soc. 1973, 95, 1328-1333.
9. (a) Richter, L. S.; Gadek, T. R. Tetrahedron Lett. 1994, 35, 4705-4706.
10. (b) Krchnak, V.; Flegelova, Z.; Weichsel, A. S.; Lebl, M. Tetrahedron Lett. 1995, 36, 6193-6196.
11. (c) Wang, Y.; Wilson, S. R. Tetrahedron Lett. 1997, 38, 4021-4024.
12. Katritzky, A. R.; Pozharski, A. F. Reactivity of Heterocycles. In Handbook of Heterocyclic Chemistry; Katritzky, A. R., Pozharski, A. F., Eds.; Elsevier Science Ltd: Oxford, UK, 2000; pp 272-274.
13. Greene, T. W.; Wutes, P. G. M. Protective Groups in Organic Synthesis, 3rd ed.; Wiley: New York, 1999; pp 86-91.
14. Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457-2483.
15. Bycroft, B. W.; Chan, W. C.; Chhabra, S. R.; Hone, N. D. J. Chem. Soc., Chem. Commun. 1993, 778-779.
16. Szardening, A. K.; Burkoth, T. S.; Look, G. C.; Campbell, D. A. J. Org. Chem. 1996, 61, 6720-6722.