Isolation of drug delivery from drug effect: Problems of optimizing delivery parameters

Neuro-Oncology

Volumn 8, Issue 2, 2006, Pages 109-118

  Ali, Mir J ^a,d   Navalitloha, Yot ^a,b   Vavra, Michael W ^a,b   Kang, Eric W Y ^a,b   Itskovich, Andrea C ^a,b   Molnar, Peter ^c   Levy, Robert M ^a,b   Groothuis, Dennis R ^a,b,e  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e EVANSTON HOSPITAL   (United States)

Author keywords

Brain tumors; Convection enhanced delivery; Drug delivery; Glioma; Interstitial fluid pressure

Indexed keywords

CARBON 14; FORMALDEHYDE; TOXIN; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BRAIN TUMOR; CELL KILLING; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; GLIOMA; NONHUMAN; RAT; TISSUE DISTRIBUTION; TISSUE PRESSURE; TREATMENT FAILURE; TUMOR CELL; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; BLOOD BRAIN BARRIER; DRUG ADMINISTRATION ROUTE; FISCHER 344 RAT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MOUSE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL LINE, TUMOR; DRUG ADMINISTRATION ROUTES; DRUG DELIVERY SYSTEMS; FORMALDEHYDE; GLIOMA; INJECTIONS, INTRAVENTRICULAR; MICE; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

EID: 33744478156     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/15228517-2005-007     Document Type: Article

References (43)

1. Bickel, U., Yoshikawa, T., and Pardridge, W.M. (2001) Delivery of peptides and proteins through the blood-brain barrier. Adv. Drug Deliv. Rev. 46, 247-279.
2. Black, K.L, Cloughesy, T., Huang, S.-C., Gobin, Y.P., Zhou, Y., Grous, J., Nelson, G., Farahani, K., Hoh, C.K., and Phelps, M. (1997) Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. J. Neurosurg. 86, 603-609.
3. Blasberg, R.G., Groothuis, D.R., and Molnar, P. (1981) Application of quantitative autoradiographic measurements in experimental brain tumor models. Semin. Neural. 1, 203-223.
4. Bullard, D.E., Schold, S.C., Jr., Bigner, S.H., and Bigner, D.D. (1981) Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. J. Neuropathol. Exp. Neurol. 40, 410-427.
5. Cohen, K.A., Liu, T., Bissonette, R., Puri, R.K., and Frankel, A.E. (2003) DAB389EGF fusion protein therapy of refractory glioblastoma multiforme. Curr. Pharm. Biotechnol. 4, 39-49.
6. Friedman, H.S., Dolan, M.E., Pegg, A.E., Marcelli, S., Keir, S., Catino, J.J., Bigner, D.D., and Schold, S.C., Jr. (1995) Activity of temozolomide in the treatment of central nervous system tumor xenografts. Cancer Res. 55, 2853-2857.
7. Giard, D.J., Aaronson, S.A., Todaro, G.J., Arnstein, P., Kersey, J.H., Dosik, H., and Parks, W.P. (1973) In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors. J. Natl. Cancer Inst. 51, 1417-1423.
8. Giussani, C., Lucini, V., Carrabba, G., Pluderi, M., Pannacci, M., Caronzolo, D., Villani, R., Black, P.McL., Carroll, R.S., Bikfalvi, A., and Bello, L. (2002) Local delivery of endogenous inhibitors effectively inhibits malignant glioma growth in vivo. Neuro-Oncology 4 (suppl. 1), S39 (abstract 159).
9. Giussani, C., Carrabba, G., Pluderi, M., Lucini, V., Pannacci, M., Caronzolo, D., Costa, F., Minotti, M., Tomei, G., Villani, R., Bikfalvi, A., and Bello, L. (2003) Local intracerebral delivery of endogenous inhibitors by osmotic minipumps effectively suppresses glioma growth in vivo. Cancer Res. 63, 2499-2505.
10. Goudar, R.K., Shi, Q., Hjelmeland, M.D., Keir, S.T., McLendon, R.E., Wikstrand, C.J., Reese, E.D., Conrad, C.A., Traxler, P., Lane, H.A., Reardon, D.A., Cavenee, W.K., Wang, X.F., Bigner, D.D., Friedman, H.S., and Rich, J.N. (2005) Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol. Cancer Ther. 4, 101-112.
11. Groothuis, D.R., Fischer, J.M., Pasternak, J.F., Blasberg, R.G., Vick, N.A., and Bigner, D.D. (1983) Regional measurements of blood-to-tissue transport in transplanted RG-2 rat gliomas. Cancer Res. 43, 3368-3373.
12. Gutmann, R., Leunig, M., Feyh, J., Goetz, A.E., Messmer, K., Kastenbauer, E., and Jain, R.K. (1992) Interstitial hypertension in head and neck tumors in patients: Correlation with tumor size. Cancer Res. 52, 1993-1995.
13. Hassenbusch, S., Levin, V., Cozzens, J., Paleologos, N., Smith, D., Phuphanich, S., Brem, S., Chen, T., Chamberlain, M., Hariharan, S., Krouwer, H., Mueller, W., Resnick, G., and Pietronigro, D. (2002) Multicenter phase I/II trial of stereotactic injection of DTI-015 into inoperable recurrent malignant glioblastoma multiforme. Neuro-Oncology 4 (suppl. 1), S43 (abstract 178).
14. Hau, P., Bogdahn, U., Steinbrecher, A., Zellner, A., Schulmeyer, F., Brawanski, A., Goldbrunner, M., Kunst, M., Stauder, G., Jachimczak, P., Schlingensiepen, K.H., and Schlingensiepen, R. (2002) Results of clinical I/II dose escalation study using the TGF-β-2 antisense oligonucleotide AP12009 administered intratumorally to patients with high-grade glioma. Neuro-Oncology 4 (suppl. 1), S44 (abstract 181).
15. Hayat, M. A. (1981) Fixation for Electron Microscopy. New York: Academic Press.
16. Hjortland, G.O., Garman-Vik, S.S., Juell, S., Olsen, O.E., Hirschberg, H., Fodstad, O., and Engebraaten, O. (2004) Immunotoxin treatment targeted to the high-molecular-weight melanoma-associated antigen prolonging the survival of immunodeficient rats with invasive intracranial human glioblastoma multiforme. J. Neurosurg. 100, 320-327.
17. Kristjansen, P.E., Boucher, Y., and Jain, R.K. (1993) Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res. 53, 4764-4766.
18. Kroll, R.A., and Neuwelt, E.A. (1998) Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means. Neurosurgery 42, 1083-1099.
19. Laske, D.W., and Rossi, P. (2002) Phase II multicenter trial of intratumoral/ interstitial therapy with transmid in patients with refractory and progressive glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA). Neuro-Oncology 4 (suppl. 1), S58 (abstract 244).
20. Lee, I., Boucher, Y., and Jain, R.K. (1992) Nicotinamide can lower tumor interstitial fluid pressure: Mechanistic and therapeutic implications. Cancer Res. 52, 3237-3240.
21. Lee, I., Boucher, Y., Demhartner, T.J., and Jain, R.K. (1994) Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br. J. Cancer 69, 492-496.
22. Leunig, M., Goetz, A.E., Dellian, M., Zetterer, G., Gamarra, F., Jain, R.K., and Messmer, K. (1992) Interstitial fluid pressure in solid tumors following hyperthermia: Possible correlation with therapeutic response. Cancer Res. 52, 487-490.
23. Luna, L.G. (Ed.) (1968) Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. New York: McGraw-Hill.
24. Mardor, Y., Roth, Y., Lidar, Z., Jonas, T., Pfeffer, R., Maier, S.E., Faibel, M., Nass, D., Hadani, M., Orenstein, A., Cohen, J.S., and Ram, Z. (2001) Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging. Cancer Res. 61, 4971-4973.
25. Miller, C.R., Williams, C.R., Buchsbaum, D.J., and Gillespie, G.Y. (2002) Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. Cancer Res. 62, 773-780.
26. Molnar, P., Fekete, I., Schlageter, K.E., Lapin, G.D., and Groothuis, D.R. (1999) Absence of host-site influence on angiogenesis, blood flow, and permeability in transplanted RG-2 gliomas. Drug Metab. Dispos. 27, 1085-1091.
27. Morrison, P.F., Laske, D.W., Bobo, H., Oldfield, E.H., and Dedrick, R.L. (1994) High flow microinfusion: Tissue penetration and pharmacodynamics. Am. J. Physiol. 266, R292-R305.
28. Netti, P.A., Baxter, L.T., Boucher, Y., Skalak, R., and Jain, R.K. (1995) Time-dependent behavior of interstitial fluid pressure in solid tumors: Implications for drug delivery. Cancer Res. 55, 5451-5458.
29. Parney, I.F., Kunwar, S., McDermott, M., Berger, M., Prados, M., Cha, S., Croteau, D., Puri, R.K., and Chang, S.M. (2005) Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma. J. Neurosurg. 102, 267-275.
30. Prados, M.D., Lang, F.F., Sherman, J.W., Strauss, L.C., Fleming, C.K., Aldape, K., Kunwar, S., Yung, W.K.A., Chang, S.M., Husain, S.R., Gutin, P.H., Raizer, J., Piepmeier, J.M., Berger, M., McDermott, M., and Puri, R.K. (2002) Convection-enhanced delivery (CED) by positive pressure infusion for intra-tumoral and peri-tumoral administration of IL13-PE38QQR a recombinant tumor-targeted cytotoxin in recurrent malignant glioma. Neuro-Oncology 4 (suppl. 1), S78 (abstract 334).
31. Reardon, D., Akabani, G., Friedman, A., Friedman, H., Herndon, J., McLendon, R., Quinn, J., Rich, J., Penne, K., Sampson, J., Shafman, T., Wong, T., Zalutsky, M.,and Bigner, D. (2002) Treatment of patients with newly diagnosed malignant gliomas using iodine 131-labeled human-mouse chimeric antitenascin monoclonal antibody 81C6 via surgically created resection cavities: Phase I/II trial results. Neuro-Oncology 4 (1), S80 (abstract 340).
32. Sampson, J.H., Reardon, D.A., Friedman, A.H., Friedman, H.S., Coleman, R.E., McLendon, R.E., Pastan, I., and Bigner, D.D. (2005) Sustained radiographie and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: Case study. Neuro-Oncology 7, 90-96.
33. Tomita, T. (1991) Interstitial chemotherapy for brain tumors: Review. J. Neurooncol. 10, 57-74.
34. 14C-sucrose delivery to RG-2 rat gliomas by intravenous and convection-enhanced delivery. Neuro-Oncology 6, 104-112.
35. Viola, J.J., Agbaria, R., Walbridge, S., Oshiro, E.M., Johns, D.G., Kelley, J.A., Oldfield, E.H., and Ram, Z. (1995) In situ cyclopentenyl cytosine infusion for the treatment of experimental brain tumors. Cancer Res. 55, 1306-1309.
36. Vriesendorp, F.J., Pegram, C., Bigner, D.D., and Groothuis, D.R. (1987) Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. J. Natl. Cancer Inst. 79, 123-130.
37. Weber, F.W., and Hingorani, V. (2002) Local treatment of recurrent glioblastoma by bulk infusion of recombinant IL-4 immunotoxin. Neuro-Oncology, 4, S101 (abstract 434).
38. Wechsler, W., Ramadan, M.A., and Geiseler, A. (1972) Isogenic transplantation of ethylnitrosourea-induced tumors of the central and peripheral nervous system in two different inbred rat strains. Naturwissenschaften 59, 474.
39. Williams, P.C., Henner, W.D., Roman-Goldstein, S., Dahlborg, S.A., Brummett, R.E., Tableman, M., Dana, B.W., and Neuwelt, E.A. (1995) Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood brain tumor barrier in the treatment of intracranial neoplasms. Neurosurgery 37, 17-27.
40. Yoshida, T., Kawano, N., Oka, H., and Fujii, K. (2000) Clinical cure of glioblastoma-two case reports. Neurol. Med. Chir. 40, 224-229.
41. Yung, W.K. (1989) In vitro chemosensitivity testing and its clinical application in human gliomas. Neurosurg. Rev. 12, 197-203.
42. Zhang, Y., and Pardridge, W.M. (2001) Rapid transferrin efflux from brain to blood across the blood-brain barrier. J. Neurochem. 76, 1597-1600.
43. Znati, C.A., Rosenstein, M., Boucher, Y., Epperly, M.W., Bloomer, W.D., and Jain, R.K. (1996) Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft. Cancer Res. 56, 964-968.