Early postnatal stimulation alters pregnane neurosteroids in the hippocampus

Psychopharmacology

Volumn 186, Issue 3, 2006, Pages 343-350

  Frye, Cheryl A ^a   Rhodes, Madeline E ^a   Raol, Yogendrasinh H ^b   Brooks Kayal, Amy R ^b,c  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Allopregnanolone; Hypothalamic pituitary adrenal; Progesterone; Stress

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CORTICOSTERONE; GESTAGEN; LITHIUM CHLORIDE; NEUROSTEROID; PREGNANE DERIVATIVE; PROGESTERONE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; DRUG EFFECT; FEMALE; GESTAGEN BLOOD LEVEL; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NEUROENDOCRINOLOGY; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROGESTERONE SYNTHESIS; RAT; STRESS;

ANIMALS; ANIMALS, NEWBORN; CORTICOSTERONE; HIPPOCAMPUS; MALE; PHYSICAL STIMULATION; PREGNANOLONE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33744470338     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-0253-7     Document Type: Article

References (48)

1. Ader R (1965) Effects of early experience and differential housing on behavior susceptibility to gastric erosions in the rat. J Comp Physiol Psychol 60:233-238
2. Ader R (1970) The effects of early experience on the adrenocortical response to different magnitudes of stimulation. Physiol Behav 5:837-839
3. Barbaccia ML, Serra M, Purdy RH, Biggio G (2001) Stress and neuroactive steroids. Int Rev Neurobiol 46:243-272
4. A receptor. Brain Res 561:157-161
5. Bitran D, Dugan M, Renda P, Ellis R, Foley M (1999) Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. Brain Res 850:217-224
6. A receptor subunit expression. Neuron 19:1103-1114
7. A and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology 22:219-229
8. Chrousos GP, Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244-1252
9. Denenberg VH, Zarrow MX, Kalberer WD, Farooq A (1963) Maternal behaviour in the rabbit: effects of environmental variation. Nature 197:161-162
10. Finn DA, Gee KW (1994) The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther 271:164-170
11. Finn DA, Roberts AJ, Long S, Tanchuck M, Phillips TJ (2003) Neurosteroid consumption has anxiolytic effects in mice. Pharmacol Biochem Behav 76:451-462
12. Frisone DF, Frye CA, Zimmerberg B (2002) Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats. Behav Brain Res 128:153-160
13. Frye CA (2001) The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents. Brain Res Brain Res Rev 37:201-222
14. Frye CA, Bayon LE (1999) Mating stimuli influence endogenous variations in the neurosteroids 3α,5α-THP and 3α-Diol. J Neuroendocrinol 11:839-847
15. Frye CA, Vongher JM (1999) 3α,5α-THP in the midbrain ventral tegmental area of rats and hamsters is increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity. J Endocrinol Invest 22:455-464
16. Frye CA, McCormick CM, Coopersmith C, Erskine MS (1996) Effects of paced and non-paced mating stimulation on plasma progesterone, 3α-diol and corticosterone. Psychoneuroendocrinology 21:431-439
17. Frye CA, Bayon LE, Pursnani NK, Purdy RH (1998) The neurosteroids, progesterone and 3α,5β-THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Res 808:72-83
18. Frye CA, Petralia SM, Rhodes ME (2000) Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP. Pharmacol Biochem Behav 67:587-596
19. Heim C, Owens MJ, Plotsky PM, Nemeroff CB (1997) The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor. Ann N Y Acad Sci 821:194-207
20. Higley JD, Suomi SJ, Linnoila M (1991) CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology (Berl) 103:551-556
21. A receptors and behavioral stress responses. Proc Natl Acad Sci U S A 100:12213-12218
22. Kehoe P, Mallinson K, McCormick CM, Frye CA (2000) Central allopregnanolone is increased in rat pups in response to repeated, short episodes of neonatal isolation. Brain Res Dev Brain Res 124:133-136
23. Kellogg CK, Frye CA (1999) Endogenous levels of 5α-reduced progestins and androgens in fetal vs. adult rat brains. Brain Res Dev Brain Res 115:17-24
24. Kellogg CK, Kenjars TP, Pleger GL, Frye CA (2005) Region-, age-, and sex-specific effects of fetal diazepam exposure on the postnatal development of neurosteroids. Brain Res Dev Brain Res (in press)
25. Levine S, Haltmeyer GC, Karas GG, Denenberg VH (1967) Physiological and behavioral effects of infantile stimulation. Physiol Behav 2:55-63
26. Macri S, Mason GJ, Wurbel H (2004) Dissociation in the effects of neonatal maternal separations on maternal care and the offspring's HPA and fear responses in rats. Eur J Neurosci 20:1017-1024
27. Madruga C, Xavier LL, Achaval M, Sanvitto GL, Lucion AB (2005) Early handling, but not maternal separation, decreases emotional responses in two paradigms of fear without changes in mesolimbic dopamine. Behav Brain Res (in press)
28. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004-1007
29. Maldonado AM, Kirstein CL (2005) Cocaine-induced locomotor activity is increased by prior handling in adolescent but not adult female rats. Physiol Behav 86:568-572
30. McCormick CM, Kehoe P, Mallinson K, Cecchi L, Frye CA (2002) Neonatal isolation alters stress hormone and mesolimbic dopamine release in juvenile rats. Pharmacol Biochem Behav 73:77-85
31. McEwen BS, Stellar E (1993) Stress and the individual. Mechanisms leading to disease. Arch Intern Med 153:2093-2101
32. Meaney MJ, Aitken DH (1985) The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters. Brain Res 354:301-304
33. Meaney MJ, Viau V, Aitken DH, Bhatnagar S (1988) Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors. Brain Res 445:198-203
34. Meaney MJ, Diorio J, Francis D, Widdowson J, LaPlante P, Caldji C, Sharma S, Seckl JR, Plotsky PM (1996) Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev Neurosci 18:49-72
35. Mensah-Nyagan AG, Do-Rego JL, Beaujean D, Luu-The V, Pelletier G, Vaudry H (2001) Regulation of neurosteroid biosynthesis in the frog diencephalon by GABA and endozepines. Horm Behav 40:218-225
36. Nilsson C, Jennische E, Ho HP, Eriksson E, Bjorntorp P, Holmang A (2002) Postnatal endotoxin exposure results in increased insulin sensitivity and altered activity of neuroendocrine axes in adult female rats. Eur J Endocrinol 146:251-260
37. Nunez JF, Ferre P, Escorihuela RM, Tobena A, Fernandez-Teruel A (1996) Effects of postnatal handling of rats on emotional, HPA-axis, and prolactin reactivity to novelty and conflict. Physiol Behav 60:1355-1359
38. Patchev VK, Almeida OF (1996) Gonadal steroids exert facilitating and "buffering" effects on glucocorticoid-mediated transcriptional regulation of corticotropin-releasing hormone and corticosteroid receptor genes in rat brain. J Neurosci 16:7077-7084
39. Patchev VK, Hassan AH, Holsboer DF, Almeida OF (1996) The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus. Neuropsychopharmacology 15:533-540
40. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322
41. Purdy RH, Morrow AL, Moore PH Jr, Paul SM (1991) Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci U S A 88:4553-4557
42. Rhodes ME, Frye CA (2001) Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decrease anxiolytic behaviors and enhances exploratory and antinociceptive behaviors. Cogn Affect Behav Neurosci 1:287-296
43. Rodbard D, Hutt DM (1974) Statistical analysis of radioimmunoassay and immunoradiometric assays: a generalized, weighted iterative, least squares method for logistic curve fitting. In: International Atomic Energy Agency (ed) Symposium on radioimmunoassay and related procedures in medicine Uniput, New York, pp 209-223
44. Seckl JR, Meaney MJ (1994) Early life events and later development of ischaemic heart disease. Lancet 342:1236
45. Serra M, Pisu MG, Littera M, Papi G, Sanna E, Tuvera F, Usala L, Purdy RH, Biggio G (2000) Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain. J Neurochem 75:732-740
46. Smythe JW, McCormick CM, Rochford J, Meaney MJ (1994) The interaction between prenatal stress and neonatal handling on nociceptive response latencies in male and female rats. Physiol Behav 55:971-974
47. Zimmerberg B, Kajunski EW (2004) Sexually dimorphic effects of postnatal allopregnanolone on the development of anxiety behavior after early deprivation. Pharmacol Biochem Behav 78:465-471
48. Zimmerberg B, Rackow SH, George-Friedman KP (1999) Sex-dependent behavioral effects of the neurosteroid allopregnanolone (3α,5α-THP) in neonatal and adult rats after postnatal stress. Pharmacol Biochem Behav 64:717-724